First Affiliated Hospital of Anhui Medical University

Lower Limb Muscle Mass Parameters Predict Short-Term Prognosis After Endovascular Intervention for Non-Thrombotic Iliac Vein Compression Syndrome With Varicose Veins

Background: Lower limb muscle mass depletion has been associated with poor outcomes in various vascular diseases, yet its prognostic role in patients with non-thrombotic iliac vein compression syndrome (NIVCS) and varicose veins (VC) undergoing endovascular intervention remains u...

Plasma interleukin-1 receptor antagonist in pediatric patients as a potential biomarker for sepsis-associated acute kidney injury: a cohort study

Our goal is to evaluate the potential of interleukin-1 receptor antagonist (IL-1Ra) as a biomarker for sepsis-associated acute kidney injury (SA-AKI). Specifically, we aim to explore the correlation between acutely elevated endogenous IL-1Ra and SA-AKI, and to identify the potent...

Hsa_circ_0001944 promotes colorectal cancer progression through the miR-665/IGF2BP1/PKM2 axis-mediated glycolysis

Colorectal cancer (CRC) is a highly heterogeneous malignancy with a poor prognosis. Although previous studies have suggested that circular RNA hsa_circ_0001944 is involved in CRC progression, its precise biological role remains unclear. This study aimed to investigate the functio...

Development and validation of a risk prediction model for postoperative frailty in breast cancer patients

Background Patients who have undergone breast cancer (BC) surgery are a high-risk population for frailty. This study aims to analyze risk factors for frailty in these patients, develop a risk prediction model, and validate its predictive performance, thereby providing a reference...

Shared‐Output Aptamer‐Gated DNA Nanodevices Program NbaSPARDA Trans‐Cleavage for Metabolite and Drug Sensing

ABSTRACT Routing chemically distinct small‐molecule aptamers into a common nuclease trans‐cleavage pathway is constrained by the target‐specific output handles of conventional structure‐switching aptamers (SSAs). Shared‐output aptamer‐gated DNA nanodevices are designed so that re...

Driver gene-based prognostic model benchmarked against machine learning survival models is associated with a CAF–TGFβ–EMT-like phenotype in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is molecularly heterogeneous, limiting conventional prognostic tools. Whole-genome resequencing of six HCC cases was used only to filter candidates. Somatically mutated genes were intersected with HCC-annotated entries from five predefined driver re...

Triglyceride-glucose-sarcopenia index and risk of cardiovascular diseases in multinational prospective cohorts

Abstract Background Muscle tissue dictates insulin-driven glucose uptake; muscle dysfunction paired with insulin resistance can trigger a compound cardiometabolic failure. However, whether this dual pathology confers incremental long-term cardiovascular risk stratification is yet...

Undifferentiated Carcinoma of the Pancreas With Osteoclast-Like Giant Cells: A Comprehensive Review of Clinical Features, Molecular Pathology, and Therapeutic Advances

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells is a rare variant of malignant pancreatic tumor, accounting for less than 1% of all pancreatic tumors. The efficacy of neoadjuvant and adjuvant chemotherapy in patients with undifferentiated carcinoma of...

Head-up lateral positioning during emergence from anaesthesia after ambulatory adenotonsillectomy in children: protocol for a multicentre randomised controlled trial

Tonsillectomy and adenoidectomy are common paediatric surgeries, with > 50% of children experiencing postoperative respiratory adverse events (PRAEs). Existing mitigation strategies have limitations, and evidence on positional interventions (e.g. lateral/semi-reclined) specifical...

Prediction of growth abnormalities in monochorionic diamniotic twin pregnancies using estimated fetal weight discordance and clinical factors: a retrospective cohort study

OBJECTIVES: To explore whether integrating additional conventional clinical or ultrasonic predictors with mid-pregnancy estimated fetal weight discordance (EFWD) can enhance the predictive ability for fetal growth abnormalities in monochorionic diamniotic (MCDA) twin pregnancies....

A hypothalamic circuit links high-fat diet exposure to anxiety-like behavior and anxiety-associated hyperphagia

Obesity and anxiety disorders are frequently comorbid, yet the neural circuit mechanisms linking metabolic and affective states remain incompletely understood. Here, in male mice exposed to long-term high-fat diet, we identify a hypothalamic circuit comprising arcuate nucleus ago...

SGK2 Promotes NEDD4L-Mediated ACSL4 Ubiquitination to Inhibit Ferroptosis and Alleviate Diabetic Kidney Disease

Aims: Despite major advances with sodium–glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, progressive tubulointerstitial injury remains a major determinant of renal function decline in diabetic kidney disease (DKD), and the molecul...

A clinical scoring system for the early identification of superinfections in patients with severe fever with thrombocytopenia syndrome: An ambispective multicentre cohort study

Background Superinfection is a major contributor to mortality in patients with severe fever with thrombocytopenia syndrome (SFTS). However, early identification remains challenging because detection of the pathogen causing the superinfection is often delayed. Objective This study...

Engineered Mitochondria-Targeted Biomimetic Hybrid Nanovesicles Ameliorate Rheumatoid Arthritis via Regulating Macrophage Autophagy and cGAS-STING Signaling

Abstract Despite decades of intensive investigation, rheumatoid arthritis (RA) remains a therapeutic challenge, primarily attributed to its intricate pathological microenvironment and poorly elucidated etiology. However, mitochondrial dysfunction and abnormal activation of the cG...

Development, validation and comparison of the nomograms for predicting postoperative survival and recurrence in gastric cancer

Gastric cancer (GC) is one of the most common malignant tumors worldwide, with an overall five-year survival rate of less than 50%. The aim of this study is to construct and validate the new nomogram model for predicting recurrence and survival of GC patients after gastrectomy. W...

Hyperglycemia alters B cell subsets contributing to osteoarthritis progression

Hyperglycemia and osteoarthritis frequently coexist as comorbid conditions, and both are characterized by chronic low-grade inflammation driven by aberrant B cell differentiation. However, the interplay between hyperglycemia, osteoarthritis, and aberrant B cell function has yet t...

eGDR and gastrointestinal cancer mortality in the UK Biobank: a prospective cohort study

Abstract Background This study examined the associations of estimated glucose disposal rate (eGDR), a surrogate of insulin sensitivity, and the insulin resistance indices TG/HDL-C and TyG with gastrointestinal (GI) cancer mortality in the UK Biobank. Methods We included 369,447 p...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Cancer-associated fibroblasts-derived CAV1 promotes epithelial-mesenchymal transition and stemness in bladder cancer through activation of the LIF/STAT3 signaling pathway

Background Cancer-associated fibroblasts (CAFs) are key components of the bladder cancer microenvironment, but how specific CAF subpopulations drive malignant progression remains unclear. This study aimed to identify CAF driver genes and elucidate the role of caveolin-1 (CAV1) in...

Changing clinical spectrum and hospital burden of pulmonary aspergillosis before and during the COVID-19 era: a 15-year single-center retrospective study

Abstract Background Pulmonary aspergillosis (PA) encompasses a heterogeneous spectrum of fungal diseases, including invasive, chronic, and allergic forms. The hospital burden and clinical characteristics of PA during the COVID-19 era remain incompletely understood. Methods We con...