First Affiliated Hospital of Anhui Medical University

Spatially defined IGF1R-STMN1 axis delineates a metastatic cell state in osteosarcoma

Abstract Metastatic osteosarcoma (OS) remains the leading cause of disease-related mortality, yet effective therapies are still lacking. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functional assays to investigate signaling dependencies in OS meta...

Neoantigen nanovaccines for cancer immunotherapy: design strategies, translational bottlenecks, and clinical prospects

Neoantigen vaccines have become an important direction in cancer immunotherapy because mutation-derived tumor antigens can induce highly specific T-cell responses while minimizing immune tolerance associated with tumor-associated antigens. However, their therapeutic performance r...