First Affiliated Hospital of Anhui Medical University

Preoperative red blood cell distribution width is associated with prolonged mechanical ventilation and in-hospital mortality after acute type A aortic dissection repair

Red blood cell distribution width (RDW) has emerged as a potential prognostic marker in cardiovascular diseases. This study aimed to investigate the association between preoperative RDW and the incidence and mortality of prolonged mechanical ventilation (PMV) in patients with acu...

Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases the risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Escherichia coli (CREC) being key drivers of treatment failure. Here, w...

PSMα contributes to Egr1-dependent early neutrophil recruitment and host defense in a murine model of Staphylococcus aureus pneumonia

Abstract Background Staphylococcus aureus ( S. aureus ) pneumonia is associated with substantial morbidity and mortality. Neutrophils play a central role in host defense against bacterial infection and are significantly increased in the lungs during S. aureus pneumonia. However,...

Bone metastasis in newly diagnosed prostate cancer: development and external validation of a diagnostic prediction model based on inflammatory-immune indices and clinicopathological factors to support imaging decisions

Accurate identification of bone metastasis at initial evaluation is essential for staging and treatment planning in newly diagnosed prostate cancer (PCa). We retrospectively analyzed a prospectively maintained database of 355 patients from the Jixi Road Campus as the development...

Diagnostic value of plasma TFF3‐centered combined biomarker panel in early gastrointestinal cancer

ABSTRACT Gastrointestinal (GI) tumors represent a significant global health burden, necessitating robust strategies for early detection. However, the clinical utility of conventional protein biomarkers such as carcinoembryonic antigen (CEA), carbohydrate antigen 19‐9 (CA19‐9) in...

Association between glycemic management during pregnancy and postpartum metabolic health outcomes among women with gestational diabetes mellitus

Abstract Background Glycemic management is standard for gestational diabetes mellitus (GDM), yet its impact on postpartum metabolic health, especially in late-onset GDM, remains uncertain. Objective To assess whether achieving glycemic control during pregnancy improves postpartum...

Altered Intersubject Variability of Morphological Connectivity in Cerebral Small Vessel Disease and Its Associations With Gene Expression and Cell Types

Background Cerebral small vessel disease (CSVD) is a heterogeneous disorder; however, interindividual variability in morphometric brain connectivity remains unclear, as does its association with gene expression. Methods We enrolled 65 patients with CSVD and 35 healthy controls. I...

Circulating and tumor microenvironment immunomarkers associate with immunotherapy efficacy in advanced bladder urothelial carcinoma: an exploratory multicenter study integrating genomic and immunophenotypic profiling

Aims To elucidate the efficacy-predictive values of immunomarkers in both peripheral blood and tumor tissue in patients with advanced bladder-urothelial-carcinoma (aBUC) undergoing first-line immunotherapy.Patients and methods In previously untreated aBUC, T-cell subclusters and...

Multi‐Scenario Adaptive High‐Fidelity Self‐Healing Elastomer Based on Poly(Ionic Liquid) Containing Polyurethane for Temperature‐Pressure Sensing and Human‐Machine Interaction

ABSTRACT Skin‐friendly ionogels with multi‐scenario adaptive, high‐fidelity, and self‐healing performances were critical building units in wearable signal transmission devices. Traditional ionogels doped with small‐molecule ionic liquids (SMILAs) into polymers yielding weak inter...

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

Preclinical Evaluation of 68Ga-Labeled Heterodimers for Dual Integrin αvβ3 and PARP1-Targeted Tumor Imaging

Abstract Tumor heterogeneity limits the diagnostic performance of molecular imaging probes targeting a single biomarker. Here, we report the design, synthesis, and preclinical evaluation of 68Ga-labelled heterodimeric radiotracers co-targeting integrin αvβ3 and poly(ADP-ribose) p...

Rapidly deployable bio-based chitosan/phytate polyelectrolyte hydrogel coatings for flame retardancy and short-term thermal protection of cotton fabrics

Cotton fabrics are highly flammable cellulose-based textiles that are prone to rapid flame spread and smoldering, creating serious fire safety risks. Hydrogel coatings offer a promising route for textile fire protection because their water-rich networks can absorb heat through ev...

Dynamic Changes and Diagnostic Value of Plasma Tryptophan and Its Metabolites in Different Stages of Hepatic Encephalopathy Detected by Ultra‐Performance Liquid Chromatography–Tandem Mass Spectrometry

ABSTRACT Hepatic encephalopathy (HE) is a severe neuropsychiatric complication of liver disease. Early diagnosis remains challenging due to insidious onset and lack of stage‐specific biomarkers. Tryptophan (TRP) metabolism is closely linked to the gut–liver–brain axis and is dysr...

Association of four nutritional indicators with all-cause and cardiovascular mortality among older Chinese adults: a prospective cohort study

Malnutrition is prevalent among older adults, yet comparative prognostic performance of nutritional indices for mortality in Chinese elderly remains unclear. To compare Geriatric Nutritional Risk Index (GNRI), Prognostic Nutritional Index (PNI), Hemoglobin-Albumin-Lymphocyte-Plat...

Discovery of Novel Pyridazine-Containing Nicotinamide Derivatives as Potent FTO Inhibitors for Acute Myeloid Leukemia

Abstract FTO has been recognized as a promising therapeutic target for acute myeloid leukemia (AML). However, the development of FTO inhibitors with anti-leukemia effects was still limited. Here, based on reasonable design and SAR, a total of 67 compounds were synthesized, among...

Corticothalamic circuits drive voluntary physical exercise-mediated relief of surgery-induced negative emotions in mice

Surgery-induced negative emotions (SINE), such as fear and anxiety, are common clinically and hinder postoperative recovery. Although physical exercise is known to modulate various affective disorders, the underlying mechanisms by which voluntary physical exercise alleviates SINE...

THBS1+ macrophages fuel pathogenic inflammation in alcohol-associated liver disease.

BACKGROUND: Alcohol-associated liver disease (ALD) is one of the most common chronic liver diseases worldwide, with a pathological spectrum ranging from simple steatosis to steatohepatitis and, ultimately, cirrhosis. Severe alcohol-associated hepatitis (sAH) arises acutely within...

Differential Psychological Effects of Daytime and Nighttime Heat Exposures on Anxiety: A Randomized Crossover Trial

Abstract Although heat exposure has been linked to adverse mental health outcomes, little is known about the different psychological effects of daytime and nighttime heat exposure. This study employed a randomized controlled crossover trial design. Between July and August 2025, 4...

The role of external fixation in the management of ischial tuberosity pressure ulcers in elderly patients: a two-center clinical study

The management of ischial tuberosity pressure ulcers in elderly patients remains a significant challenge in surgical treatment, with high risks of wound dehiscence and recurrence following traditional flap reconstruction. This study aimed to evaluate the efficacy of a novel exter...

Socioeconomic status and resilient coping in rare disease patients: the chain-mediating roles of social support and family resilience

Abstract Background In China, over 20 million individuals live with rare diseases (RDs), yet they continue to face systemic challenges including limited awareness among healthcare professionals, high misdiagnosis rates, diagnostic delays, and poor access to medications. Strengthe...