East China University of Science and Technology

Gas Identification Driven by Dynamic Response Fragments and Multi-Task Learning

Abstract The electronic nose system has attracted much attention due to its wide application in industrial detection, atmospheric monitoring and noninvasive disease diagnosis. However, the traditional methods are limited in accuracy and generalization due to the lack of selectivi...

Multikilogram-Scale Process Development for a Key Intermediate of a Clinical-Stage MTA-Cooperative PRMT5 Inhibitor

Abstract A multikilogram-scale, scalable, and cGMP-compliant synthesis of 4-aminoimidazo[1,5-a]quinoxaline-8-carboxylic acid (TM), a key intermediate for the MTA-cooperative PRMT5 inhibitor GTA182, has been developed to address the limitations of the original medicinal chemistry...

Does the increase in the minimum wage standard affect corporate innovation? Empirical evidence from Chinese A-share listed companies

Based on the data of Chinese A-share listed companies from 2000 to 2017, a system dynamic panel model is adopted to examine the impact and action mechanisms of the minimum wage standard on the “quantity” and “quality” of corporate innovation in China. Our study finds that: (1) th...

Microscopic Dynamic Mechanisms of Surfactant-Induced Skin Irritation

Abstract Surfactants are essential components of detergents and personal care products due to their unique amphiphilic structure. However, the mechanism underlying surfactant-induced skin irritation remains unclear. This study systematically combined experiments with molecular dy...

Optimization of dynamic admission control for preemptible cloud services based on TPD-SAC reinforcement learning

Abstract Preemptible cloud services utilize idle resources from contract-based services. The resources allocated to these low-priority services can be preempted by contract-based services during periods of overload, so cloud platforms offer low prices to attract cost-sensitive us...

Renewable oil-derived comb polymers as green and shear-resistant wax-crystal modifiers for high-wax crude oils

The formation of robust wax-crystal networks in high-wax crude oils during cooling leads to significant increases in viscosity, gelation, and restart stress, posing major challenges for pipeline transportation. Here, we present a renewable, oil-derived comb polymer strategy that...

Biomanufacturing of 2-Pyrone-4,6-dicarboxylic Acid by an Engineered Corynebacterium glutamicum Cell Factory

2-Pyrone-4,6-dicarboxylic acid (PDC) is a promising pseudo-aromatic bio-based monomer for the production of biodegradable polyesters. Here, we combined metabolic engineering with fermentation process optimization to establish efficient de novo PDC biosynthesis in Corynebacterium...

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

ABSTRACT Intrauterine injury triggers a self‐reinforcing cycle of inflammation, oxidative stress, and fibrosis that culminates in intrauterine adhesions (IUA), severely impairing women's reproductive health. Current treatments, including hysteroscopic adhesiolysis combined with h...

Sparse semi-interpretable networks for discovering nonlinear dynamics with time-varying parameters and switching structures

Data-driven equation discovery has emerged as a new focal point in nonlinear dynamics. While significant progress has been made in identifying governing equations of time-invariant dynamical systems, the existing approaches still encounter considerable obstacles when applied to s...

BMP-2-driven osteo-organoid formation retains key osteogenic-support features and promotes bone repair following total-body irradiation

Irradiation stress causes persistent skeletal injury by disrupting marrow homeostasis, stromal function, and bone repair. However, the temporal remodeling of the native bone microenvironment and the capacity of a biomaterial-induced osteogenic environment to sustain regeneration...

Integrating Central-City Parks into Everyday Activity Chains: Boundary-Opening Optimization and Spatial-Network Reconfiguration with the Park-BIND Model

Urban parks in city centers are often assessed by residential proximity, but visits in districts with mixed land uses also occur between work, shopping, services, and other daily activities. A nearby park may remain difficult to use when its entrances and internal paths do not al...

Gender differences in prolonged grief: a network perspective on symptom interconnections and functional impairment

Background: While prior studies have reported gender differences in prolonged grief symptom severity, less is known about symptom interconnections and their associations with functional impairment. Clarifying these may inform more targeted bereavement care.Methods: A total of 1,0...

From Taxonomy to Causality: Exploring Construction Dispute Factors Using a Gaussian KGE, CN, and DEMATEL-Based Approach

Abstract Despite advances in construction project management and technology, disputes remain a persistent challenge that significantly undermines project quality, cost, and schedule performance. A major reason is that dispute causes are often multifaceted and interdependent, yet...

Community Environment, Parenting Practices, Social Support, and Children’s Quality of Life in Shanghai, China: A Multi-Scalar and Gendered Analysis

Abstract This study investigates the relationships between community environment, parenting practices, social support, and children’s quality of life in Shanghai. Grounded in a “4D” framework (Density, Design, Diversity, and Destination), we employed a multi-scalar geospatial app...

Enhanced heparosan biosynthesis in Corynebacterium glutamicum by systematic metabolic engineering and translation-level fine-tuning

As a widely used anticoagulant, heparin is industrially produced chiefly via animal tissue extraction, which suffers from unstable supply and potential safety hazards. Heparosan shares a similar polysaccharide backbone with heparin and can be converted into heparin under mild enz...

A Non-Invasive Transtympanic Bioadhesive Hydrogel for Sustained Delivery of Dexamethasone in Otitis Media Effusion Therapy

Abstract Otitis media with effusion (OME) is a highly prevalent condition characterized by persistent inflammatory effusion in the middle ear cavity. The clinical management of OME remains challenging due to the anatomical inaccessibility of the middle ear, which limits drug effi...

Manipulating Valence‐Heterogeneous Pt Dual Sites via Metal‐Support Interactions for Highly Efficient Alkaline Hydrogen Evolution

ABSTRACT Alkaline water electrolysis is essential for sustainable green hydrogen production but is bottlenecked by sluggish water dissociation kinetics and catalyst degradation at high current densities. Herein, a low loading of Pt nanoclusters (4.2 wt.%) was anchored on multiwal...

MindForm — Cognitive Patterns: A Stateless Interpretive Layer for Experience-Driven Personality in LLM Agents

The two preceding papers in this series document personality as state: a temperament and trait vector a character is born with, and the values, moral outlook, beliefs and habits they earn by living. Both described a feedback loop in which that state colors how future experience i...

Tokenizing Loyalty Programs: The Role of Tradability

Problem Definition. Loyalty programs (LPs) are widely used to enhance customer retention and firm profitability. With technological advancements like blockchain, many brands are exploring tokenized LPs. Unlike traditional LPs, where rewards can only be redeemed for future purchas...

Formation of a silica scaffold with a hyperbolic surface structure as a time-frozen glimpse by ultraviolet curing

Abstract Triply periodic hyperbolic surfaces have been extensively investigated in various natural and artificial self-assembled systems and have attracted great attention because of their complexity and geometrical beauty. However, understanding their formation during bottom-up...