East Carolina University

Predicting Young Adults’ Fertility Preferences: Individual, Relational, and Family-of-Origin Influences

Declining fertility rates in the United States have increased interest in the factors shaping young adults’ fertility intentions. Guided by a life course perspective, this study examined how individual characteristics, relationship orientations, and family-of-origin dynamics are...

Role of Health-Related Discrimination on Academic Performance Among Children with Congenital Heart Disease

Abstract Congenital heart disease (CHD) can lead to neurodevelopmental impairments and increased need for routine healthcare visits, potentially leading to deficits in academic performance. Children with CHD may also experience health-related discrimination in school and clinical...

Does Race Influence Velopharyngeal Structure Size and Velar Stretch During Sustained Phoneme Production in Children?

Purpose: Differences in the size of velopharyngeal structures across racial groups at rest have been described in the literature, with race influencing adenoid thickness, pharyngeal depth, effective velar length, and velar length. The purpose of this study was to examine differen...

Pharmacokinetic and pharmacodynamic sub-study of trans-arterial vs. intravenous gemcitabine in the TIGeR-PaC phase 3 clinical trial

Abstract Purpose Localized intra-arterial delivery of gemcitabine (IAG) may provide advantages in terms of increased tissue concentration and decreased systemic dosing. We hypothesized IAG may result in decreased systemic gemcitabine concentration and associated side effects due...

HMGB1 andHMGB2 Are O 4-Alkylthymidine-BindingProteins

Abstract Exposure to endogenous and exogenous sources of alkylating agents leads to DNA lesions that can impair cell survival and confer genome instability by eliciting mutations during DNA replication and transcription. Among the DNA alkylation adducts, O4-alkylthymidine (O4-alk...

Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics.

Female gametogenesis in Drosophila melanogaster requires differentiation and mitotic division of germ cells, acquisition of oocyte fate, and entry into meiosis. Each of these processes is well understood individually; however, little is known about the mechanisms that ensure prop...