Deutsches Zentrum für Psychische Gesundheit

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

Attitudes Toward Evidence-based Practice in Child and Youth Welfare: The Role of Implementation Climate and Professional Quality of Life

3Abstract Evidence-based practices (EBPs) can support the delivery of high-quality, evidence-informed care for children and adolescents, yet are rarely implemented in German Child and Youth Welfare Service (CYWS) facilities. Although attitudes toward EBPs have been associated wit...

Critical windows: timing of child maltreatment exposure and adult mental health

Abstract Background Despite being recognized as the leading risk factor for mental disorders, child maltreatment (CM) remains insufficiently understood regarding type and timing of exposure. This study examines which developmental periods of exposure to CM subtypes are most stron...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...