Dartmouth College

Multi-Institutional Data for Faculty Well-Being Improvements Within and Across Medical Schools

Importance Burnout, engagement, and satisfaction vary in prevalence and correlate with organizational performance in US medical colleges. Large-scale improvements have been elusive. Objective To quantify rates of well-being and its organizational correlates so to help identify op...

A Cox-Based Framework for Quantile Estimation

Quantile regression (QR) provides a flexible framework for characterizing conditional distributions and can offer useful insights for quantile estimation. In this paper, we provide intuition for the interpretation of QR by highlighting the approach that it is a reparameterization...

Host-secreted lactate during respiratory viral infection diminishes macrophage antibacterial activity through metabolic reprogramming

ABSTRACT In polymicrobial infections, how the host recognizes and responds to pathogens influences which species will persist to cause chronic infections. The human respiratory tract is a common anatomical site for viral-bacterial co-infections, where primary viral infections pre...

Intermittent hypoxia interventions for inducing ventilatory acclimatization to high altitude?

Accumulation of ∼200 h of hypoxia exposure (pre-acclimatization) has been suggested to prevent the development of acute mountain sickness when a person is subsequently exposed to high altitude. These pre-exposures are typically undertaken intermittently at or near the place of re...

Integrated differential transcript usage and transcript abundance analyses reveal isoform-level remodeling in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is characterized by transcriptional reprogramming driven by hypoxia signaling, metabolic rewiring, and immune modulation. While gene-level analyses have defined key features of ccRCC biology, they do not capture isoform-level variation aris...

Design Thinking Improved Transitional Care Management and Primary Care Continuity in Rural America

BACKGROUND: Transitional care management (TCM) supports timely postdischarge follow-up and is associated with decreased emergency department visits and 30-day readmissions. However, delivering TCM in rural settings remains challenging, and staff frequently report frustration with...

Pediatric Mental Health Integration and Perceived Quality of Care

OBJECTIVE: This study examined how access to behavioral and mental health (B/MH) professionals varied across general and subspecialty pediatricians and whether access to, and degree of, B/MH integration in clinical settings was associated with pediatricians' perceptions of health...

A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis

Mammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments. We applied DNA Typewriter, a sequential molecular recorder, to record the cell lineage of a mouse over nearly two weeks of development. From one embryo, we reconstruct a time-calibr...

Reduced Carbon Emissions and Chain Elongation during Mixotrophic Fermentation of a Biomass Feedstock

Abstract Anaerobic fermentation of biomass feedstocks using open cultures is a promising technology to produce platform carboxylates. Syngas, a mixture of H2, CO2, and CO, can be sourced sustainably and used to supplement biomass feedstocks as a source of acetyl-CoA, an intermedi...

Using Representation Learning and Website Text to Identify Competitor Networks

This paper introduces a new approach to identify competitors using company websites to map competitive relationships among public and private firms. We apply representation learning techniques to create embeddings of companies based on website content, emphasizing information abo...

Climate informed pediatric care – Nurturing a better future for children

Introduction Climate change poses significant health risks and children are particularly vulnerable to its effects. In 2024, the American Academy of Pediatrics (AAP) updated its clinical recommendations for climate-informed care in a policy statement, urging pediatricians to inco...

Nonlinear longitudinal stress coupling in glacier and ice sheet flow

Abstract The Greenland and Antarctic ice sheets exhibit high variability in flow speed, over multiple orders of magnitude. This flow integrates forcings from complex, multi-scale and spatially heterogeneous pressure gradient and friction fields into smooth and continuous flow fie...

Cognitive appraisal processes mediate postinjury pain and disability: A longitudinal observational study.

PURPOSE/OBJECTIVE: Psychological appraisal processes of pain catastrophizing (PC) and perceived injustice (PI) are involved in the transition to postinjury disability. Although these factors are modifiable and may serve as ideal intervention targets to improve recovery, they have...

PHASED study archive | U.S. eGrid 2022 | egrid2020_technical_guide.pdf

Original file used in the PHASED study, Correlated uncertainty propagation enables multi-impact decision support for electrical system decarbonization. File: egrid2020_technical_guide.pdf. Source group: U.S. eGrid 2022. Study file location: 4 External Data/U.S. eGrid 2022/egrid20...

PHASED study archive | NREL ATB | AWS S3 Explorer for the Open Energy Data Initiative.pdf

Original file used in the PHASED study, Correlated uncertainty propagation enables multi-impact decision support for electrical system decarbonization. File: AWS S3 Explorer for the Open Energy Data Initiative.pdf. Source group: NREL ATB. Study file location: 4 External Data/NREL...

PHASED study archive | NREL ATB | AWS S3 Explorer for the Open Energy Data Initiative.pdf

Original file used in the PHASED study, Correlated uncertainty propagation enables multi-impact decision support for electrical system decarbonization. File: AWS S3 Explorer for the Open Energy Data Initiative.pdf. Source group: NREL ATB. Study file location: 4 External Data/NREL...

PHASED study archive | U.S. EIA 860 | EIA-860 instructions.pdf

Original file used in the PHASED study, Correlated uncertainty propagation enables multi-impact decision support for electrical system decarbonization. File: EIA-860 instructions.pdf. Source group: U.S. EIA 860. Study file location: 4 External Data/U.S. EIA 860/eia8602023/EIA-860...

Structural stigma and LGBTQ+ youth mental health in the United States

Structural stigma, or systemic barriers to equity for minoritized populations, has been shown to have negative consequences on LGBTQ+ youth’s mental health. Most research has focused on stigma at the national or state level, limiting understanding of how local institutions and en...

A phase II pilot trial of an indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor (INCB024360) plus a multipeptide melanoma vaccine (MELITAC 12.1) in patients with advanced melanoma, with sequential evaluation of the tumor microenvironment

Indoleamine 2,3-dioxygenase-1 (IDO1) can mediate immune dysfunction by reducing tryptophan (Trp) and increasing kynurenine (Kyn). The CITN-04 clinical trial (NCT01961115) tested the safety and clinical activity of combination therapy with IDO1 inhibitor epacadostat (INCB024360) p...

The Shape-Shifting Margin: Patterns of Change in Arabic Modernism Past Beirut

This essay presents an initial foray into the rich field of modern Arabic poetry after the canonization phase of modernism in midcentury Beirut. Though by no means offering an exhaustive account, the chosen case studies are claimed to cover major orientations in forms of second-w...