Institution
Dalian Medical University
Recent research
- Health & MedicineOpen access
Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with limited molecular targets. This study aimed to identify candidate genes involved in ICC progression and to examine the functional role of PBK. Integrated bioinformatics analysis was performed on TCGA-CHOL data...
- Health & MedicineOpen access
Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...
- BiologyOpen access
Breast invasive carcinoma (BRCA) is a major cause of cancer-related mortality in women. PIGU , a subunit of the GPI-anchor biosynthesis complex, has been reported to be dysregulated in several cancers; however, its prognostic value and immune-related associations in BRCA remain u...
- Engineering & TechnologyOpen access
Interpretable AI-driven materiomics to decode microenvironmental cues for stem cell immunomodulation
Abstract Hydrogels that mimic the extracellular matrix create microenvironments containing diverse physicochemical cues that regulate stem cell fate, particularly their immunomodulatory and pro-regenerative functions. However, elucidating how microenvironmental cues regulate cell...
- Health & MedicineOpen access
Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and anti...
- Engineering & Technology
ABSTRACT High‐contrast imaging and effective treatment of hepatocellular carcinoma (HCC) remain challenging, largely due to the limited tumor selectivity of existing contrast agents and the absence of stable and broadly conserved therapeutic targets. Herein, we report a photoacti...
- Engineering & Technology
ABSTRACT High‐contrast imaging and effective treatment of hepatocellular carcinoma (HCC) remain challenging, largely due to the limited tumor selectivity of existing contrast agents and the absence of stable and broadly conserved therapeutic targets. Herein, we report a photoacti...
- Health & MedicineOpen access
Disability is a major challenge affecting older adults’ quality of life. Although the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has been shown to protect against functional disability in Western populations, its applicability across different cultura...
- Health & MedicineOpen access
Clinical Relevance of Bile Acid and Bile Acid-Related Therapy in Liver Cirrhosis: A Review
Cirrhosis, the end stage of various chronic liver diseases, is characterized by complex pathophysiologies and poor outcomes. Recently, dysregulation of bile acid metabolism has been increasingly recognized as a key factor in the development and progression of liver cirrhosis and...
- Health & MedicineOpen access
Cervical cancer (CCa) patients with lymph node metastasis (LNM) have poor outcomes and limited therapeutic options. This study investigated the expression, function, and mechanisms of low-density lipoprotein receptor-related protein 8 (LRP8) in CCa-associated LNM. LRP8 expression...
- Health & MedicineOpen access
Abstract Background Motoric cognitive risk syndrome (MCR), defined by subjective cognitive complaints and slow gait in individuals without dementia, is a clinically relevant pre-dementia phenotype. Platelets are increasingly linked to inflammation, endothelial dysfunction, and ne...
- BiologyOpen access
Circadian rhythms have been implicated in the regulation of cardiovascular physiology and disease. Disruption of circadian signaling has been linked to exaggerated neointimal hyperplasia and delayed endothelial repair. Bmal1, a core component of the molecular clock, plays a criti...
- Health & MedicineOpen access
Aims Although intra-articular vancomycin has demonstrated satisfactory outcomes for periprosthetic joint infection (PJI), dose and dosing frequency remain largely empirical. This study aimed to develop a target-based population pharmacokinetics (PK) model to predict local vancomy...
- Health & MedicineOpen access
Abstract Purpose Junior physicians may experience critical competency gaps during the transition to unsupervised practice, particularly in high-risk specialties such as anesthesiology, where errors can compromise patient safety. Although large language models (LLMs) are being rap...
- Health & MedicineOpen access
Early risk stratification remains challenging in patients with acute aortic dissection (AAD). This study aims to evaluate the prognostic value of neutrophil percentage-to-albumin ratio (NPAR) for in-hospital mortality in patients with acute aortic dissection. We performed a multi...
- Health & Medicine
ABSTRACT Background This study assessed the real‐world hepatotoxicity of third‐generation aromatase inhibitors (AIs) for breast cancer using pharmacovigilance approaches. Methods FAERS data (Q1 2004–Q1 2025) were analysed using a data‐driven disproportionality analysis framework...
- Health & MedicineOpen access
Background Sex-based differences in treatment response to neuroprotective strategies during endovascular treatment (EVT) for acute ischemic stroke remain poorly understood. Objectives This study aimed to evaluate sex-specific effects of methylprednisolone on outcomes after EVT fo...
- Health & MedicineOpen access
OBJECTIVES: Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with adverse maternal and fetal outcomes. Although the prevalence of GDM is high, the molecular mechanisms involved in GDM-related placental dysfunction remain poorly understood. This st...