Dalian Medical University

Phragmites Communis (Lu Gen) Alleviates Hyperuricemia via Xanthine Oxidase Inhibition and Gut-Microbiota-Mediated Metabolite Urate Transporter Regulation

Background: Hyperuricemia (HU) results from excessive uric acid (UA) production/impaired excretion and is associated with gout and renal dysfunction. Gut microbiota dysbiosis may impair intestinal UA excretion, disrupt the gut barrier, and promote inflammation. Traditional Chines...

The membrane skeleton density of red blood cells in MYH9 -related disease patients is decreased

MYH9-related disease (MYH9-RD) is a rare autosomal dominant disorder caused by mutations in MYH9 gene, which encodes the heavy chain of nonmuscle myosin IIA. Nearly all MYH9-RD patients present with macrothrombocytopenia, characterized by decreased platelet count and increased pl...

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis. Clinically, RA manifests as joint pain, swelling, and functional impairment caused by persistent synovial inflammation. Additionally, RA can involve vital organs, inc...

Characterizations of the multi-kingdom gut microbiota in elderly individuals with end-stage renal disease

End-stage renal disease (ESRD) is common in older adults and has been linked to gut dysbiosis, yet multi-kingdom alterations and cross-kingdom interactions in elderly patients remain incompletely defined. We characterized the gut bacteriome, mycobiome, and virome in elderly indiv...

A study of medical students’ perception of the risk of future job displacement and adaptive behaviors in the context of artificial intelligence

Abstract Against the backdrop of rapid advances in artificial intelligence (AI) technology, an increasing number of jobs are facing significant challenges, particularly in the healthcare sector. The development of AI not only puts forward new career requirements for healthcare pr...

High‐throughput identification of carboxylate‐free ligands for the E3 ligase Kelch domain‐containing protein 2

Abstract Expanding the repertoire of usable E3 ubiquitin ligases remains a critical challenge in the field of targeted protein degradation. For the emerging E3 ligase Kelch domain‐containing protein 2 (KLHDC2), currently reported ligands have a carboxylate moiety in common that m...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Abstract Glioma poses a formidable therapeutic challenge due to its cellular heterogeneity, invasiveness and the protective blood‐brain barrier (BBB). Boron neutron capture therapy represents a promising binary targeted radiotherapy, but its efficacy is hampered by insufficient t...

Assessing the content quality of Douyin and Bilibili as health information sources for pulmonary tuberculosis: a cross-sectional study

Pulmonary tuberculosis (PTB) remains a major global infectious disease, and short-video platforms are increasingly used for health information seeking. However, the quality, reliability, disease-specific accuracy, and safety of PTB-related videos on major Chinese platforms have n...

Synergistic catalytic therapy of severe acute pancreatitis using gold-doped prussian blue nanozymes via targeting ROS-NLRP3 inflammatory cascade

Severe acute pancreatitis (SAP) is characterized by a complex and poorly understood pathogenesis, with a lack of specific therapeutic agents. Herein, we develop morphology-engineered gold-doped Prussian blue nanozymes (AuPB), designed as reactive oxygen species (ROS) scavengers f...

Coronary Calcification: A Nuanced View

Coronary artery calcification (CAC) is a marker of atherosclerosis. Various quantitative indicators, such as CAC score (CACS) and CAC volume, are associated with the risk of major adverse cardiovascular events (MACE), whereas CAC density has a protective effect. However, the inte...

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing

BACKGROUND: Myocardial ischemia/reperfusion injury triggers profound metabolic reprogramming and lactate accumulation. However, how this metabolic stress regulates inflammatory gene expression remains poorly understood. We hypothesized that lactylation, a lactate-derived posttran...

Clues From the Device: Individualized Programming to Solve a Pacing‐Facilitated AVNRT

ABSTRACT A dual‐chamber pacemaker patient with sick sinus syndrome presented with a slow, long‐RP′ tachycardia. Device interrogation revealed that a spontaneous PVC reset the tachycardia, excluding atrial tachycardia. A subsequent atrial paced beat advanced the next QRS, excludin...

Cellular subpopulation remodeling and biphasic molecular dynamics in glioma recurrence: a multi-omics analysis and diagnostic markers screening using liquid biopsy samples

OBJECTIVE: Glioblastoma (GBM) is a highly aggressive brain tumor with a median survival of about 15 months and frequent recurrence. Liquid biopsy of cerebrospinal fluid (CSF) and plasma enables minimally invasive detection of tumor-associated molecular signals and may improve ear...

Association between plaque quantification from coronary CTA and myocardial flow reserve derived from CT myocardial perfusion imaging

Although the relationship between coronary stenosis and myocardial perfusion is well established, the association between quantitative plaque parameters and myocardial perfusion remains poorly understood. This study investigated the association between quantified plaque parameter...

Antibody-Drug Conjugates in the Treatment of Esophageal Cancer

Esophageal cancer remains one of the most lethal malignancies worldwide, with particularly poor outcomes following disease progression after first-line chemoimmunotherapy. Antibody-drug conjugates (ADCs) have emerged as a transformative therapeutic class that combines the targeti...

Regional ventilation at EIT-guided PEEP and mortality in severe ARDS: a prospective observational study

Severe acute respiratory distress syndrome (ARDS) is characterized by regional mechanical heterogeneity and systemic inflammation. Electrical impedance tomography (EIT) can individualize positive end-expiratory pressure (PEEP), but the prognostic value of EIT-derived variables me...

Validation of Newcastle ENDOPREM for assessing patient experience with colonoscopy: a multicenter prospective study

Patient experience is a key quality indicator for colonoscopy, yet standardized assessment tools are lacking in China. The Newcastle ENDOPREM scale has shown promise internationally but requires validation in China. To translate, adapt, and preliminarily evaluate the psychometric...

Bone cement pulmonary and intracardiac embolism following percutaneous vertebroplasty: a case report and literature review

Pulmonary embolism and intracardiac cement embolism caused by venous leakage of bone cement are the most serious complications following percutaneous vertebroplasty. Although the incidence of such events is low, they are insidious due to variable clinical symptoms, prone to being...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...