Dalian Medical University

Bone cement pulmonary and intracardiac embolism following percutaneous vertebroplasty: a case report and literature review

Pulmonary embolism and intracardiac cement embolism caused by venous leakage of bone cement are the most serious complications following percutaneous vertebroplasty. Although the incidence of such events is low, they are insidious due to variable clinical symptoms, prone to being...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

The clinicopathological and molecular characterization in ascites-derived paraffin-embedded cell blocks of ovarian cancer

Abstract This study evaluated immunohistochemical (IHC) markers and homologous recombination repair (HRR) gene mutations in 58 ovarian cancer patients using ascites-derived paraffin-embedded cell blocks. IHC analysis revealed high expression of Pax-8 (87.5–100%), WT-1 (87.8–90%),...

EXPRESS: Risk factors and predictive model for non-aspiration stroke-associated infections in patients with acute ischemic stroke followed by intravenous thrombolysis

OBJECTIVE: To analyze clinical characteristics, risk factors, and a predictive model for non-aspiration stroke-associated infections (NASAI) in acute ischemic stroke (AIS) patients receiving intravenous alteplase thrombolysis. METHODS: This prospective cohort study included AIS p...

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dent...

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease, with podocyte injury driving disease progression. Mitochondrial dysfunction and ferroptosis contribute to podocyte loss, yet the underlying molecular mechanisms remain incompletely understood. The anti-a...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...

First‐Phase Ejection Fraction: A Novel Approach to Detecting Early Systolic Dysfunction in Hypertrophic Cardiomyopathy

ABSTRACT Background The assessment of stable coronary artery disease has been performed using the first‐phase ejection fraction (EF1) in previous research. However, the use of EF1 has seldom been employed in the evaluation of early left ventricular systolic dysfunction among pati...

Analysis of the factors influencing the treatment zone area after overnight orthokeratology lens wearing

Abstract Purpose To validate the agreement between R language (R) and MATLAB for measuring orthokeratology (OK) lens treatment zone parameters, and identify the influencing factors of the treatment zone area (TZA). Methods A retrospective study included 239 children (7–16 years)...

Renal tubule-targeted biomimetic nanodrugs achieve precise AKI treatment by halting pro-inflammatory crosstalk between proximal tubular epithelial cells and macrophages

Acute kidney injury (AKI) is a critical clinical disorder characterized by high incidence, high mortality, and numerous complications. However, current supportive therapies cannot reverse established injury, leading to poor outcomes in some patients, and thus, necessitating the d...

Serum neutrophil elastase as a potential non-invasive biomarker for assessing hepatic fibrosis in chronic hepatitis B patients

The role of neutrophil elastase (NE) in liver fibrosis caused by chronic hepatitis B (CHB) has not been fully clarified. This study sought to measure serum NE concentrations in individuals with CHB and to determine whether NE could serve as a noninvasive indicator for assessing C...

Leptomeningeal fibroblasts promote glioblastoma progression by regulating cerebrospinal fluid dynamics

Abstract Cerebrospinal fluid contributes to homeostasis in the central nervous system, but how its dynamics are altered in glioblastoma is unclear. We find that glioblastoma drives leptomeningeal perivascular fibrosis that is associated with impaired fluid transport and clearance...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Paeoniflorin Alleviates Oxygen–Glucose Deprivation/Reoxygenation Injury by Mediating Crosstalk Between Neurons and Endothelial Cells Through the VEGF/PI3K-AKT/mTOR Pathway

Background/Objectives: Cerebral ischemia–reperfusion injury (CIRI) poses therapeutic challenges because of oxidative stress, blood–brain barrier disruption, and neuronal apoptosis, limiting current treatments. Paeoniflorin (PF) from Paeonia lactiflora has neuroprotective potentia...

Gut microbiota-derived acetate mitigates Escherichia fergusonii-induced gut dysbiosis exacerbating Klebsiella pneumoniae pulmonary infection in mice

Escherichia fergusonii is an emerging food-borne opportunistic pathogen that disrupts gut homeostasis and exacerbates the severity of other organ diseases. However, the effects of gut colonization by E. fergusonii on the gut-lung axis remain unclear. Here we show that the abundan...

ElectrochemiluminescenceMicroscopy

Abstract Electrochemiluminescence (ECL) microscopy is an emerging imaging technology that combines electrochemistry with optical microscopy. It operates without external light excitation, effectively eliminating photobleaching, phototoxicity, and scattered light noise, and thus e...

Temporal dynamics of PrEP adherence, self-efficacy, and risk perception among men who have sex with men in western China: a cross-lagged panel network analysis

<title>Abstract</title> Background Pre-exposure prophylaxis (PrEP) effectively reduces HIV infection risk among men who have sex with men (MSM), but its benefit depends on adherence. The longitudinal item-level relationships among PrEP adherence, self-efficacy, and risk perceptio...

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state and the energy-conserving, ordered (OFF) state. By shifting the ON/OFF equilibriu...

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

TREM2 regulates continual efferocytosis of apoptotic neurons by monocyte-derived macrophages via AKT-PFKFB2-mediated glycolytic reprogramming after acute ischemic stroke

Efficient clearance of apoptotic neurons is crucial for mitigating secondary injury after acute ischemic stroke (AIS). Although monocyte-derived macrophages (MDMs) rapidly infiltrate the ischemic brain and upregulate triggering receptor expressed on myeloid cells 2 (TREM2) expres...