Dalian Medical University

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

ABSTRACT Hepatic ischemia‒reperfusion injury (HIRI) critically compromises liver surgery and transplantation outcomes. Its pathogenesis centers on mitochondrial dysfunction‐driven oxidative stress and sterile inflammation. However, current therapies lack lesion‐specific targeting...

Gut–Mammary Axis-Mediated Improvement of Sialylated Milk Oligosaccharide Synthesis by Polygonatum sibiricum Polysaccharide and Probiotics in Mice with Gestational Metabolic Disorders

Abstract Milk oligosaccharides (MOs) are vital for infant health but vulnerable to gestational metabolic dysfunction. To explore a new microecological intervention strategy, we established a probiotic fermentation platform coupled with a mammary epithelial cell screening model to...

Association of sulfur microbial diet with lung cancer incidence and lung cancer-related mortality in 95,612 American adults: a prospective cohort study from the PLCO trial

The sulfur microbial diet (SMD) score is a microbiome-related dietary proxy derived from food groups associated with sulfur-metabolizing bacteria. Whether it is associated with lung cancer remains unclear. We analyzed 95,612 participants from the Prostate, Lung, Colorectal, and O...

Brain-computer interfaces: innovations and challenges in the field of cerebral palsy rehabilitation

Brain-computer interfaces have shown great potential in the rehabilitation of Cerebral palsy, improving the ability of children with cerebral palsy to perform activities of daily living by replacing and restoring lost neurological functions, as well as accurately evaluating cogni...

Isoliquiritigenin Triggers HMOX1-Driven Ferroptosis to Suppress Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death, and new treatment strategies are needed. Ferroptosis is an iron-dependent cell death driven by lipid peroxidation, and targeting ferroptosis has become a new strategy for anti-NSCLC. Isoliquirit...

Emerging roles of long non-coding RNA CASC2 in tumor chemoresistance – a review

Malignant tumors remain a leading cause of global mortality, and the development of chemoresistance represents a major obstacle to effective cancer treatment. Long non-coding RNAs (lncRNAs) are important regulators of tumor progression and therapeutic response. Cancer susceptibil...

A dual-functional, responsive nanomodulator alleviates pyroptosis-associated lung injury in ARDS by selectively suppressing the cGAS–STING signaling axis

Injury and inflammation mediated by pulmonary endothelial cell pyroptosis are crucial factors in the progression of acute respiratory distress syndrome (ARDS). Although blocking the cyclic GMP‒AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway is a promi...

Prognostic factors and nomograms predicting overall survival and cancer specific survival for patients with rare histological variant prostate cancer

Our study aimed to develop nomograms to accurately predict the 1-, 3-, and 5-year overall survival (OS) and cancer-specific survival (CSS) of patients with rare histological variant prostate cancer (PCa) based on clinicopathological characteristics. We gathered clinicopathologica...

National Epidemiological Trends in Hepatitis A–E Serologic and Virologic Markers in the United States, 2011–2023: A Population-Based Study

Viral hepatitis caused by A to E imposes a substantial global burden of liver disease. Despite US control strategies, long-term national data covering serologic markers of all five hepatitis viruses remain limited. In this study, we analyzed epidemiologic trends from 2011 to 2023...

Outpatient versus telephone follow-up and blood pressure control in China: a longitudinal study in primary care

As the population ages, long-term standardized management of hypertension has become a critical task for primary healthcare systems. Telephone follow-up is widely used as a supplementary approach to outpatient care; however, its long-term effectiveness in real-world settings rema...

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

ABSTRACT Joint profiling of chromatin accessibility and gene expression in the same cell enables direct linkage of regulatory elements to transcriptional output, but existing approaches remain limited by low co‐capture sensitivity, proprietary platforms, and high costs. Here we p...

The CMPK2–mtDNA axis mediates doxorubicin cardiotoxicity: mechanistic links to STAT1 transcription and FAD-mediated inhibition

Abstract Aims Doxorubicin is a widely used chemotherapeutic agent whose clinical utility is limited by dose-dependent cardiotoxicity. The precise mechanisms bridging mitochondrial dysfunction to cardiac inflammatory responses remain poorly defined. Methods and results We utilized...

Cerebellar α-synucleinopathy contributes to Parkinsonian gait and balance impairment in mouse models

Postural instability and gait difficulty (PIGD) represent a debilitating clinical subtype of Parkinson’s disease (PD) that is largely refractory to dopaminergic replacement therapy. While clinical imaging implies that the cerebellum is involved in these axial deficits, the specif...

Bacterial outer membrane vesicles encapsulating oncolytic virus for targeted nose-to-brain delivery

Oncolytic virus therapy, as an emerging anti-tumor biological therapy, has demonstrated significant therapeutic potential for brain tumors in clinical studies. However, due to the special anatomical barrier of the brain tissue, the application of oncolytic viruses is currently li...

Development and validation of a predictive model for osteoporosis in middle-aged and older patients with type 2 diabetes mellitus: a multicenter retrospective study

The increasing prevalence of type 2 diabetes mellitus (T2DM) and osteoporosis (OP) among aging populations necessitates early OP risk identification. This study developed and validated a nomogram for predicting OP risk in middle-aged and older T2DM patients, and explored dose-res...

tNGS-guided diagnosis of pulmonary mucormycosis with bacterial coinfection in new-onset diabetes: a case report

Abstract Background Pulmonary mucormycosis is a rapidly progressive and potentially fatal fungal infection, particularly in patients with uncontrolled diabetes. Early diagnosis can be challenging when invasive tissue sampling is high-risk or infeasible. Targeted next-generation s...

Graph neural network-based service migration decision in vehicular networks

Abstract The rapid development of the Internet of Vehicles (IoV) has led to an exponential increase in the number of latency sensitive and computationally intensive tasks. Due to the limitations of onboard computing resources in vehicles, offloading these tasks generated during v...

Aqueous extract of Nasturtium officinale: a potential therapeutic approach to be explored in the fight against multidrug-resistant Pseudomonas aeruginosa

The rise in global bacterial resistance has made the development of new therapies an urgent challenge, positioning Pseudomonas aeruginosa as a critical priority pathogen. In this context, phytotherapy stands out due to the wide diversity of bioactive compounds with antimicrobial...

Triglyceride-glucose-sarcopenia index and risk of cardiovascular diseases in multinational prospective cohorts

Abstract Background Muscle tissue dictates insulin-driven glucose uptake; muscle dysfunction paired with insulin resistance can trigger a compound cardiometabolic failure. However, whether this dual pathology confers incremental long-term cardiovascular risk stratification is yet...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...