Dalian Medical University

ElectrochemiluminescenceMicroscopy

Abstract Electrochemiluminescence (ECL) microscopy is an emerging imaging technology that combines electrochemistry with optical microscopy. It operates without external light excitation, effectively eliminating photobleaching, phototoxicity, and scattered light noise, and thus e...

Gut microbiota-derived acetate mitigates Escherichia fergusonii-induced gut dysbiosis exacerbating Klebsiella pneumoniae pulmonary infection in mice

Escherichia fergusonii is an emerging food-borne opportunistic pathogen that disrupts gut homeostasis and exacerbates the severity of other organ diseases. However, the effects of gut colonization by E. fergusonii on the gut-lung axis remain unclear. Here we show that the abundan...

Temporal dynamics of PrEP adherence, self-efficacy, and risk perception among men who have sex with men in western China: a cross-lagged panel network analysis

<title>Abstract</title> Background Pre-exposure prophylaxis (PrEP) effectively reduces HIV infection risk among men who have sex with men (MSM), but its benefit depends on adherence. The longitudinal item-level relationships among PrEP adherence, self-efficacy, and risk perceptio...

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state and the energy-conserving, ordered (OFF) state. By shifting the ON/OFF equilibriu...

TREM2 regulates continual efferocytosis of apoptotic neurons by monocyte-derived macrophages via AKT-PFKFB2-mediated glycolytic reprogramming after acute ischemic stroke

Efficient clearance of apoptotic neurons is crucial for mitigating secondary injury after acute ischemic stroke (AIS). Although monocyte-derived macrophages (MDMs) rapidly infiltrate the ischemic brain and upregulate triggering receptor expressed on myeloid cells 2 (TREM2) expres...

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

Dental Erosion and Therapeutic Options

Tooth wear is a common, multifactorial non-carious dental hard tissue disease, and it may lead to a range of problems such as hypersensitivity, occlusal dysfunction, and aesthetic defects, significantly impacting patients’ oral health and quality of life. This article aims to sys...

A portable nanobiosensor with machine learning: enabling multi-cytokines point-of-care testing and early identification of sepsis immunoparalysis

Abstract Sepsis immunoparalysis (SIs) is a major factor contributing to organ dysfunction. However, emergency departments (EDs) and intensive care units (ICUs) currently lack a rapid workflow for early identification of SIs. Herein, an innovative strategy for early SIs identifica...

PIGU expression is associated with poor prognosis and estimated immune cell infiltration in breast invasive carcinoma

Breast invasive carcinoma (BRCA) is a major cause of cancer-related mortality in women. PIGU , a subunit of the GPI-anchor biosynthesis complex, has been reported to be dysregulated in several cancers; however, its prognostic value and immune-related associations in BRCA remain u...

TCGA-based identification and functional validation of PBK in intrahepatic cholangiocarcinoma progression with involvement of AKT signaling

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with limited molecular targets. This study aimed to identify candidate genes involved in ICC progression and to examine the functional role of PBK. Integrated bioinformatics analysis was performed on TCGA-CHOL data...

Interpretable AI-driven materiomics to decode microenvironmental cues for stem cell immunomodulation

Abstract Hydrogels that mimic the extracellular matrix create microenvironments containing diverse physicochemical cues that regulate stem cell fate, particularly their immunomodulatory and pro-regenerative functions. However, elucidating how microenvironmental cues regulate cell...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and anti...

Photo‐Generated 1 O 2 Triggers In Situ RNA Crosslinking for High‐Contrast Tumor MRI and Effective Tumor Suppression

ABSTRACT High‐contrast imaging and effective treatment of hepatocellular carcinoma (HCC) remain challenging, largely due to the limited tumor selectivity of existing contrast agents and the absence of stable and broadly conserved therapeutic targets. Herein, we report a photoacti...

Photo‐Generated 1 O 2 Triggers In Situ RNA Crosslinking for High‐Contrast Tumor MRI and Effective Tumor Suppression

ABSTRACT High‐contrast imaging and effective treatment of hepatocellular carcinoma (HCC) remain challenging, largely due to the limited tumor selectivity of existing contrast agents and the absence of stable and broadly conserved therapeutic targets. Herein, we report a photoacti...

Association between the Chinese version of the Mediterranean-DASH intervention for Neurodegenerative Delay diet and BADL/IADL disability among older adults in China: a nationwide survey

Disability is a major challenge affecting older adults’ quality of life. Although the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has been shown to protect against functional disability in Western populations, its applicability across different cultura...

Endothelial Bmal1 coordinates intrinsic and paracrine mechanisms to limit post-injury vascular restenosis

Circadian rhythms have been implicated in the regulation of cardiovascular physiology and disease. Disruption of circadian signaling has been linked to exaggerated neointimal hyperplasia and delayed endothelial repair. Bmal1, a core component of the molecular clock, plays a criti...

Association of platelet count with incident motoric cognitive risk syndrome among Chinese adults aged 60 years or older: a national prospective cohort study

Abstract Background Motoric cognitive risk syndrome (MCR), defined by subjective cognitive complaints and slow gait in individuals without dementia, is a clinically relevant pre-dementia phenotype. Platelets are increasingly linked to inflammation, endothelial dysfunction, and ne...

LRP8 drives cervical cancer lymph node metastasis by promoting epithelial-mesenchymal transition and VEGF-C secretion

Cervical cancer (CCa) patients with lymph node metastasis (LNM) have poor outcomes and limited therapeutic options. This study investigated the expression, function, and mechanisms of low-density lipoprotein receptor-related protein 8 (LRP8) in CCa-associated LNM. LRP8 expression...

Clinical Relevance of Bile Acid and Bile Acid-Related Therapy in Liver Cirrhosis: A Review

Cirrhosis, the end stage of various chronic liver diseases, is characterized by complex pathophysiologies and poor outcomes. Recently, dysregulation of bile acid metabolism has been increasingly recognized as a key factor in the development and progression of liver cirrhosis and...