Comenius University Bratislava

PPGLomics: An Interactive Platform for Pheochromocytoma and Paraganglioma Transcriptomics

Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors with unique biological behavior and remarkably high heritability, yet dedicated bioinformatics resources for these diagnoses remain limited. Existing cancer multi-omics platforms are pan-cancer in scope, oft...

Direct Anterior Approach is Associated with Superior Postoperative Sexual Function Compared with Anterolateral Approach in Men Undergoing Total Hip Arthroplasty: A Prospective Cohort Study

Abstract Objectives Total hip arthroplasty (THA) is increasingly performed in younger men, many of whom regard sexual function as an important component of postoperative quality of life. Regular sexual activity contributes to overall well-being. Hip osteoarthritis (OA) impairs se...

Cortical Bipolarity Underlies Microtubule-Dependent Bidirectional Gliding in the Deep-Branching Apicomplexan Polyrhabdina pygospionis (Gregarinassina)

Manuscript in preparation — 30 August 2026 This is a work-in-progress manuscript prepared within Project No. 09I03-03-V04-00162, funded by the EU NextGenerationEU through the Recovery and Resilience Plan for Slovakia. This version is publicly deposited to document the current sta...

Preliminary miRNA profiling of plasma from patients infected with distinct SARS-CoV-2 variants

Background Epigenetic regulation can play a dual role in viral infection, acting as part of the host defense, while being hijacked to control viral latency, replication, and persistence. During the COVID-19 pandemic, substantial evidence indicated that different SARS-CoV-2 varian...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Surface DBD plasma functionalization of the interior of PVC and PTFE tubes: effects on surface properties and environmental safety assessment of leaching

This study investigates the internal surface modification of polytetrafluoroethylene (PTFE) and poly(vinyl chloride) (PVC) tubes using a liquid-electrode surface dielectric barrier discharge (SDBD) plasma system. The approach addresses the “hollow body problem” by enabling unifor...

Perioperative Management of Patients Taking GLP-1 Receptor Agonists. A Mini-Review

In July 2025, the British Journal of Anaesthesia published recommendations for the perioperative management of patients using GLP-1 receptor agonists. The authors of this multidisciplinary consensus are SPAQI, the Society for Perioperative Assessment and Quality Improvement. GLP-...

EUPopLink Country report - Slovakia

This article explores the intersection of populism and Euroscepticism within the Slovak political landscape, demonstrating how European issues have evolved from a largely depoliticised post-accession consensus to a pivotal domain of domestic political competition. The article foc...

Enzyme-Detergent and Detergent-Detergent Protocols for Human Urethra Decellularization: A Histological and Ultrastructural Study

Abstract Background and Objectives Decellularization of the human urethra produces extracellular matrix (ECM) bioscaffolds with strong potential for reconstructive urology, yet no standardized protocols exist for either cell removal or scaffold characterization. Histological asse...

Early development of anoxia prior to the main euxinic phase of the Jenkyns Event on the margin of the Western Tethys (Sachrang Basin, Eastern Alps)

ABSTRACT Although the global expansion of oxygen‐depleted marine environments during the Early Toarcian Jenkyns Event (or Toarcian Oceanic Anoxic Event) is primarily inferred from successions in the NW European epicontinental basins, the timing of the expansion of anoxia in Tethy...

Facile and FastMicrowave-Assisted Synthesis of MetalatedPCN-222 for Light-Driven Hydrogen Evolution Reaction

Abstract Porphyrinic metal–organic frameworks (PMOFs) have the capacity to incorporate metalloporphyrins (MPs) into their structure. While this ability opens the door to many potential applications, the synthesis of metal-incorporated PMOFs typically involves multistep protocols,...

Condition-Specific LC Retention Time Prediction: Feature-Selected QSRR Versus Pretrained Graph Isomorphism Network Transfer Learning

Condition-specific liquid chromatographic retention time prediction remains challenging because retention depends on both molecular structure and experimental conditions. This study compared feature-selected quantitative structure–retention relationship (FS-QSRR) models with pret...

1% Acetic Acid as an Effective and Cytocompatible Antimicrobial Agent with Enhanced Activity in Acellular Dermal Matrix for Wound Management

Abstract Objectives To evaluate the antimicrobial efficacy, antibiofilm activity, cytocompatibility, and biomaterial compatibility of 1% acetic acid (AA), including its application within acellular dermal matrix (ADM) for advanced wound management. Methods Antimicrobial activity...

Religious Education, Psychosocial Learning, and the Formation of Prosocial Behaviour: A Conceptual Study in Christian Educational Contexts

This article examines the role of psychosocial learning in the formation of prosocial behaviour within Christian religious education and broader religiously informed educational settings. While prosocial behaviour is frequently analysed from psychological, pedagogical, or sociolo...

Common pathways and outliers in glucose catabolism across Trypanosomatidae

Glucose catabolism in trypanosomatids differs significantly from that in most other eukaryotes. Here, the first few enzymes of the pathway are all located inside glycosomes, that is, the peroxisome‐like microbodies uniquely present in the Kinetoplastida and Diplonemida of the Eug...

Liddicoatite, Ca(Li2Al)Al6(Si6O18)(BO3)3(OH)3OH, a rare, long-anticipated OH-dominant species of the tourmaline supergroup

Abstract Liddicoatite, ideally Ca(Li2Al)Al6(Si6O18)(BO3)3(OH)3OH, is a new mineral species of the tourmaline supergroup and the OH-dominant analogue of fluor-liddicoatite. The name liddicoatite was originally applied to a species that was subsequently renamed fluor-liddicoatite f...

Receiver function imaging reveals Pyrenean-style crustal wedging in the Western Carpathians

The Alpine−Tethys suture in the Western Carpathians records the collision between the northern European passive margin and the Adria-derived Alps−Carpathians−Pannonian (AlCaPa) tectonic unit. Previous tectonic models, largely based on indirect evidence, proposed complex configura...

CRISPR/Cas9-edited organoids as a platform for tailored research of colorectal cancer

Colorectal cancer is one of the most commonly diagnosed cancers worldwide. Mortality rates and limited therapeutic options justify the development of reliable preclinical research models, as their translational value remains limited. Simple in vitro models do not recapitulate tum...

Carbapenem-Resistant Klebsiella pneumoniae Producing Single or Dual Carbapenemases and Emergence of ST395 Strains Co-harbouring NDM-5 and OXA-232 in Selected University Hospitals

Abstract Background Emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains poses a serious global threat, driven by expansion of high-risk clones producing dual carbapenemases and exhibiting increased antimicrobial resistance. Materials and methods We investigated...