Columbia University Irving Medical Center

Acute Myeloid Leukemia Involving the Skin

ABSTRACT Leukemia cutis (LC) refers to cutaneous infiltration by leukemic cells, most often by acute myeloid leukemia (AML) in adults and by lymphoblastic leukemia in children. Although uncommon, LC is a clinically significant manifestation of extramedullary disease and may prece...

Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of de novo Polycomb recruitment

Polycomb domains safeguard cell identity by maintaining lineage-specific chromatin states enriched in repressive histone modifications, preserving the epigenetic memory of cell lineages. While Polycomb repressive complex 2 (PRC2) can reestablish its occupancy after perturbation,...

Maternal Outcomes Among Periviable Births by Cesarean Delivery

Importance Contemporary estimates of adverse maternal outcomes associated with periviable cesarean delivery are important for patient counseling and clinical decision-making. Objective To characterize trends, risks factors, and adverse maternal outcomes associated with periviable...

Influence of Chronic Kidney Disease on Outcomes After Paclitaxel-Coated Balloon Angioplasty for Coronary In-Stent Restenosis

BACKGROUND: Drug-coated balloons (DCB) are superior to conventional balloon angioplasty in coronary in-stent restenosis. The influence of chronic kidney disease (CKD) on outcomes after DCB for in-stent restenosis is not well described. METHODS: A post hoc analysis of the AGENT ID...

Prioritizing Global Health Education in Pulmonary and Critical Care Fellowships: An Applicant Survey

Abstract Background Global Health (GH) is expanding, offering an increasing number of opportunities for engagement to trainees in medical schools and residency programs. This expansion of opportunities has not yet reached those at the fellowship level, particularly in Critical Ca...

A Scoping Review of Psychological Distress Outcomes in NICU Healthcare Providers

The Neonatal Intensive Care Unit (NICU) is a demanding work environment that provides medical care for acutely ill and premature infants while supporting parents experiencing significant stress and psychological distress. This scoping review is the first to examine quantitative r...

Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons

The association of cues with the absence or presence of danger is crucial to survival. The synaptic changes that enable association with the absence of danger are unknown, but a role for the tail of the striatum (TS) has been implicated. To investigate this, we conditioned mice t...

A genetic and historical perspective on the origins of keratitis fugax hereditaria

Abstract Purpose To investigate the genetic and genealogical background of keratitis fugax hereditaria (KFH), a periodic corneal disease caused by the heterozygous pathogenic variant c.61G>C in the NLRP3 gene. KFH is characterized by recurrent unilateral autoinflammatory attacks...

How common is alcohol use disorder in posttraumatic stress disorder? A systematic review, meta‐analysis, and moderator analysis

BACKGROUND AND OBJECTIVES: Comorbidity between posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) complicates care, yet reported prevalence varies widely across settings and methods. We estimated AUD prevalence among adults with PTSD and identified sources of var...

Hearing Loss Is Associated With Regional Brain Amyloid in a Late Middle‐Aged Cohort

ABSTRACT Objectives Investigate the association of hearing loss (HL), measured by pure‐tone average (PTA) and word recognition score (WRS) in the better ear, with cerebral amyloid deposition, measured with amyloid positron emission tomography (PET). Methods Two‐hundred twenty‐thr...

Gait Speed in Spinal Muscular Atrophy: A Key Vital Sign Linked to Strength and Fatigability

ABSTRACT Introduction/Aims Gait Speed (GS), a valid and reliable indicator of function and health in multiple populations, has not been explored in spinal muscular atrophy (SMA). The purpose of this study was to characterize GS and gait speed reserves (GSR), and explore associati...

The Impact of v‐SYMPHONY's Virtual Boot Camp on Trainee Transition From Residency to Fellowship

BACKGROUND: Starting a pediatric subspecialty fellowship presents numerous challenges to trainees. Virtual Symposium of Pediatric Hematology/Oncology of New York (v-SYMPHONY), an educational collaborative organized by 18 pediatric hematology-oncology (PHO) programs, initiated an...

Iatrogenic tensor fascia lata damage during direct anterior approach total hip arthroplasty: a prospective study of frequency, timing, and risk factors

The tensor fascia lata (TFL) muscle is prominent during the direct anterior approach (DAA) for THA and can be injured. This study aimed to determine patient or procedure-related risk factors for damage. One hundred consecutive THAs from November 2024 through March 2025 performed...

Immunomodulatory Drugs and Cereblon E3 Ligase Modulators in Multiple Myeloma: 30 Years in the Making

Immunomodulatory drugs (IMiDs) have fundamentally reshaped multiple myeloma therapy, extending survival and establishing durable backbones across induction, relapse, and maintenance. Cereblon's identification as a druggable E3 ligase substrate receptor created the mechanistic pat...

Neighborhood Contemporary Redlining and Racial Mortgage Lending Bias and Cardiovascular Outcomes in Women With Breast Cancer

BACKGROUND: Studies have demonstrated neighborhood structural inequities are associated with cardiovascular outcomes among breast cancer survivors. We investigated the associations between bias in mortgage lending practices (contemporary redlining and racial lending bias) and car...

Colorectal cancer screening with multitarget-stool DNA testing: real-world adherence and follow-up colonoscopy in a large urban academic health system

OBJECTIVE: This real-world study evaluated adherence to multitarget-stool DNA (mt-sDNA) testing and completion of follow-up colonoscopy (FU-CY) among patients aged 45-75 years in NewYork-Presbyterian, a large urban healthcare system. METHODS: This retrospective analysis of tests...

Universal Newborn Screening for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in a Safety-Net Well-Baby Nursery: A Quality Improvement Initiative

Background: G6PD deficiency is among the leading causes of neonatal hyperbilirubinemia and kernicterus. Following a 2022 New York State Department of Health recommendation to test high-risk neonates, we implemented universal G6PD deficiency screening in the well-baby nursery. Obj...

Management strategies in endogenous fungal endophthalmitis: a multi-institutional retrospective cohort study

Background/aims Standardised treatment guidelines for endogenous fungal endophthalmitis (EFE) are lacking. The purpose of this study is to describe treatment strategies and clinical outcomes of eyes with EFE. Methods Retrospective cohort study performed at eight academic institut...

Family mass murder in the United States, 1970–2019: Perpetrator mental health characteristics and the role of domestic violence

Abstract Examining perpetrator characteristics of, and risk factors for, different types of mass murder, such as family mass murder—the most common type—could have important ramifications for preventive efforts. Histories of domestic violence and mental illness are of particular...

Impulse Control Disorders Are Independent of Parkinson Disease Motor Subtypes

Objective: Impulse control disorders (ICDs) are clinically important nonmotor features of Parkinson's disease (PD). Tremor-dominant PD (TD-PD) has been associated with greater cerebello-thalamo-cortical involvement, whereas postural instability/gait difficulty-dominant PD (PIGD-P...