Columbia University Irving Medical Center

Optimizing Portal Venous Phase Acquisition Quality of Contrast-Enhanced CT in Oncology

Background: Portal venous phase (PVP) contrast-enhanced CT is a cornerstone for response assessment in early-phase oncology trials, yet contrast-enhancement phase timing remains insufficiently monitored across sites. We assessed PVP timing using a validated artificial intelligenc...

Psychological Stress and the Diurnal Patterns of Sodium Excretion and Blood Pressure: Results From the SABRE Study

BACKGROUND: Psychological stress is associated with reduced blood pressure (BP) dipping, but the underlying mechanisms are unclear. This study examined the associations among stress-induced sodium excretion, diurnal sodium excretion, and BP dipping. METHODS: Apparently healthy ad...

Surgical and Radiographic Outcomes in Cervical Deformity Patients with High T1 Slope and High C2 Slope (HTHC) Versus Low T1 Slope and High C2 Slope (LTHC)

Study Design. Retrospective analysis of a prospective multicenter operative cervical deformity (CD) database. Objective. To determine whether T1 slope (T1S) and C2 slope (C2S) together identify distinct CD phenotypes: cervical-only versus global sagittal deformity, and to compare...

Challenges in Diagnosing Primary Ciliary Dyskinesia and the Role of Nasal Nitric Oxide Testing: A Single Center Experience

Rationale: Nasal nitric oxide (nNO) measurement is a recommended noninvasive screening tool for primary ciliary dyskinesia (PCD), but studies examining its real-world performance are limited, and integration of PCD diagnostic pathways varies across centers. Objective: The objecti...

Plasma Phosphorylated Tau 217 Percentage by Race and Ethnicity in Preclinical Alzheimer Disease

Importance In trials targeting preclinical Alzheimer disease (AD), defined as amyloid pathology without cognitive symptoms, racial and ethnic differences in plasma phosphorylated tau 217 percentage (%p-tau217) may influence screening eligibility. Objective To characterize racial...

Imputed Rare‐Variant Aggregate Analysis Is a Powerful Approach to Detect Genetic Associations

ABSTRACT Imputation can cost‐effectively generate genotypes for millions of variants. This study evaluated the power of performing rare‐variant aggregate association tests using imputed genotypes. UK Biobank exome‐sequence data and variants obtained via imputation using the HRC (...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Polygenic Risk Scores in Alzheimer’s Disease: A Cross-Scale View from Genes to Brain and Behavior

Alzheimer’s disease (AD) is a genetically complex disorder in which inherited susceptibility is distributed across rare high-impact variants, the apolipoprotein E (APOE) locus, and a broad polygenic background of common risk alleles. Polygenic risk scores (PRSs) provide a quantit...

Associations of Mild or Trace Valvular Abnormalities With Cardiac Remodeling in Older Adults: The ARIC Study

Background The impact of mild/trace valvular abnormalities on cardiac remodeling is not well understood, despite their association with poor cardiovascular outcomes. Methods Using data from 4684 participants in the ARIC (Atherosclerosis Risk in Communities) Study (2011–2013), age...

Cervical Disc Arthroplasty: Evolution, Evidence, and Future Directions in Motion-Preservation Surgery

➢ Cervical disc arthroplasty (CDA) provides clinical outcomes comparable with those of anterior cervical discectomy and fusion (ACDF) for 1-level and 2-level cervical degenerative disc disease (DDD), with durable long-term motion preservation. ➢ Although CDA is associated with lo...

sRQA: an integrative pipeline for symbolic recurrence quantification analysis

Recurrence Quantification Analysis (RQA) is a powerful phenomenological method for characterizing dynamical systems from sequential empirical data, but it is fundamentally limited to continuous signals. Symbolic RQA (sRQA) extends this framework to discrete state sequences, enabl...

Can Psychological Readiness Predict Successful Return to Sports After Patellar Stabilization Surgery in Adolescent Patients? A Retrospective Cohort Study

Background: While many metrics are used to subjectively assess a patient’s knee function with patellofemoral instability (PFI), psychological readiness to return to sport (RTS) after patellar stabilization surgery is not well established in this population. The Anterior Cruciate...

Clarifying the Concept of “Unanticipated Transfer to the ICU”: A Scoping Review

Unanticipated transfer to the intensive care unit (ICU), typically defined as an unscheduled escalation of care from inpatient general wards, is widely used in clinical research as a marker of adverse events, clinical deterioration, and system failure. However, its conceptual mea...

Cinematic rendering for characterization of anomalous coronary origins: visualization of interarterial courses and post-surgical assessment

Cinematic rendering is an advanced three-dimensional post-processing technique that applies Monte Carlo-based global illumination to CT datasets, producing photorealistic volumetric reconstructions that enhance depth perception and tissue-plane visualization compared with convent...

Inflation-Adjusted Medicare Reimbursement for Common Dermatologic Procedures

This cross-sectional study examines inflation-adjusted reimbursement for 46 common dermatologic procedures from 2007 to 2026, focusing particularly on the 2021-2026 interval.

Hypertension Management and Control in Cienfuegos, Cuba

This population-based cross-sectional survey assesses hypertension prevalence and indicators of management and control in 2023 and compares these findings with a similar population-based survey conducted in 2011.

Unearthing Toxic Beauty: Project CLEAR Protocol to Assess Skin-Lightening Product Exposure in Northern Manhattan

Skin lightening products (SLPs) are widely used among communities of color and often contain toxic chemicals that pose serious health risks. Despite regulations, these products remain accessible in the United States through deceptive labeling and illegal sales, which might contri...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

A common germline 3′ UTR variant controls DDIT4 translation efficiency and stress responses in cancer cells

Systematic strategies for identifying and classifying variants that directly modulate ribosome engagement are lacking. Here, we develop and extensively validate a pipeline to identify translation-associated single-nucleotide polymorphisms (tranSNPs) by integrating analysis of tot...

Impact of Primary Prophylactic Colony-Stimulating Factor Delivery Method on Febrile Neutropenia: Secondary Analysis of a Pragmatic Cluster Randomized Clinical Trial

Purpose Primary prophylactic colony-stimulating factor (PP-CSF) is recommended for patients receiving chemotherapy with high risk of febrile neutropenia (FN). The impact of PP-CSF delivery method on FN is unknown. We performed a secondary analysis of SWOG S1415CD (Trial Assessing...