Cleveland Clinic

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

Anatomical and Histologic Response to Neoadjuvant Therapy: Recurrence Patterns Among Poor Responders. A Multi-institutional Observational Cohort Study.

OBJECTIVE: To characterize the prognostic implications after hepatectomy for colorectal liver metastases (CRLM) by integrating anatomical response to neoadjuvant therapy (NAT), quantified using the Tumor Burden Score ratio (TBSr), with histologic response assessed by Tumor Regres...

Grief in Neurosurgery: Reframing Loss and Identity Through Lived Experience.

Grief is an under-recognized yet pervasive experience in neurosurgery, arising not only from the death of patients and loved ones but also from losses related to professional identity, health, and personal relationships. Despite its relevance, grief is often conflated with burnou...

Clinical outcomes of patients with brain metastases from colorectal cancer treated with stereotactic radiosurgery.

Background: Brain metastases from gastrointestinal primaries, including colorectal cancer (CRC), have been shown to respond less favorably to stereotactic radiosurgery (SRS) compared with other primary sites. We report institutional outcomes of patients with brain metastases from...

A Hybrid Quantum–AI Framework for Protein Structure Prediction on NISQ Devices

Variational quantum algorithms provide a direct, physics-based approach to protein structure prediction, but their accuracy is limited by the coarse resolution of the energy landscapes generated on current noisy devices. We propose a hybrid framework that combines quantum computa...

Association of coexisting celiac disease with macrovascular and microvascular complications in adults with type 2 diabetes mellitus: a retrospective propensity score–matched cohort study

Abstract Background Celiac disease (CD) and type 2 diabetes mellitus (T2DM) are increasingly recognized as overlapping metabolic conditions. However, the impact of concomitant CD on diabetes-related complications and metabolic outcomes in patients with T2DM remains poorly charact...

PD GENEration: an international Parkinson’s disease genetic research study

Abstract Background PD GENEration (NCT04057794, NCT04994015), sponsored by the Parkinson's Foundation in partnership with Aligning Science Across Parkinson’s (ASAP) through the Global Parkinson’s Genetics Program (GP2), is an international, observational, clinical research study...

Plasma indole-3-propionic acid is a gut-derived metabolite and is associated with type 2 diabetes and cardiometabolic outcomes: Evidence from a human antibiotic intervention

The gut microbiota influences host metabolism through diverse metabolites, many of which have been linked to glucose homeostasis and type 2 diabetes (T2D). Understanding microbial contributions to metabolite biosynthesis is essential for developing dietary and microbiota-targeted...

Immunotherapy-Related Cardiac Arrythmias: Incidence, Pathobiology, Risk Factors and Management

Abstract Purpose of Review Immunotherapies have revolutionized treatment strategies for cancer patients, improving the prognosis in many populations with advanced malignancies. Immune check point inhibitors (ICI) and Chimeric antigen receptor (CAR) T cell therapy are being increa...

Top Ten Tips Palliative Care Clinicians Should Know About Collaborating with Consultation-Liaison Psychiatry

Palliative care (PC) and consultation-liaison (CL) psychiatry are complementary clinical disciplines that frequently care for the same patients facing serious illness complicated by psychiatric symptoms, psychological distress, neuropsychiatric syndromes, and high-stakes medical...

Expanding the Donor Pool: Successful Single Lung Transplant of a Hepatitis C Seropositive Donor to a Recipient With HIV and Pulmonary Fibrosis

Melissa Lesko, DO is on the advisory board for patientMpower, Ltd. (10/13 Thomas St. Dublin, Ireland). Bonnie Lonze, MD PhD has received research funding from AbbVie, Inc for work unrelated to this manuscript. The other authors declare no conflicts of interest.

Evolution of Endoscopic Spine Surgery: Contemporary Advances and Future Directions

Abstract Purpose of review Endoscopic spine surgery has evolved from non-visualized percutaneous discectomy only, into a comprehensive minimally invasive surgical platform with expanding indications across cervical, thoracic, and lumbar pathology. This review examines endoscopic...

Transanal robotic versus endoscopic submucosal dissection for complex distal colorectal lesions: a comparative study

Abstract Background Endoscopic submucosal dissection (ESD) is technically challenging for complex colorectal lesions, while endorobotic submucosal dissection (ERSD) has emerged as a transanal minimally invasive alternative offering high-definition 3D visualization and improved in...

Distinct inflammatory marker profiles of adolescents and young adults among the HIV risk, infection, and treatment spectrum

Abstract Youth living with or at HIV-risk exhibit distinct immune perturbations during HIV exposure, infection, and antiretroviral therapy (ART). Understanding immune perturbations is critical for development of tailored prevention and enhanced therapeutic strategies. We performe...

Clinical characteristics, presentation, and outcomes in patients with thoracic aortic thrombus

Background: Thoracic aortic thrombosis (TAT) is a rare, but important cause of arterial thromboembolism (ATE). There is a paucity of published data on TAT; therefore, risk stratification and management are challenging. In this study, we evaluated risk factors, presentation, and o...

LDL-C vs Lp(a): What We Know, the “Zero-LDL” Hypothesis, and Where We Stand in the PCSK9 Era

Despite significant breakthroughs in preventative medicine, atherosclerotic cardiovascular disease (ASCVD) is still the primary cause of morbidity and death worldwide. In this context, 2 apoB-containing particles-LDL and lipoprotein(a) [Lp(a)] have emerged as important but mechan...

Association between chiropractic spinal manipulation and adverse vascular events of the head and neck: systematic review and meta-analysis

Abstract Background Observational studies have raised concerns about a potential association between chiropractic spinal manipulation (CSM) and craniocervical vascular events (CCVE), including cervical artery dissection and stroke. We tested the null hypothesis of no significant...

Early Intraretinal Fluid Reduction is Linked to Vision Gains in Patients with Diabetic Macular Edema

This analysis evaluated the impact of early intraretinal fluid (IRF) reduction on long-term visual outcomes in patients with diabetic macular edema (DME). This was a treatment-agnostic, post hoc analysis of pooled data from patients with DME in YOSEMITE/RHINE (NCT03622580/NCT0362...

Implementing Congenital CMV Screening in a Large Hospital System

BACKGROUND AND OBJECTIVES: Congenital cytomegalovirus (cCMV) is the most common congenital infection and the leading nongenetic cause of sensorineural hearing loss. Despite expanding legislative screening requirements across the United States, there is no consensus guidance on th...

Examining the Relation Between Intimate Partner Violence and Housing Instability by Gender

Abstract Purpose Survivors of intimate partner violence (IPV) frequently face housing challenges both during and after experiencing abuse. Although previous studies have identified a link between IPV and housing instability, limitations in measurement and sampling have left signi...