Cleveland Clinic

Early Introduction and Prolonged Full‐Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort

Background Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management. Methods We retrospec...

Patient‐Reported Outcome Measures in Musculoskeletal Oncology: Current Concepts, Barriers, and the Future

Patient-reported outcome measures (PROMs) remain underutilized in musculoskeletal oncology, with only 4.9% of tumor-focused articles incorporating them. This review synthesizes current PROM instruments-including Toronto Extremity Salvage Score, PROMIS, and emerging tools such as...

Cardiovascular Manifestations of Cystic Fibrosis

Cystic fibrosis (CF) has undergone a remarkable transformation from a fatal childhood disease to a chronic adult condition, with a median predicted survival now exceeding 50 years following the introduction of highly effective CFTR modulator therapy (HEMT). This demographic shift...

Changes in Coronal and Sagittal Plane Alignment After Transphyseal ACL Reconstruction Performed Within Two Years of Skeletal Maturity: Results From the PLUTO Study Group

Background: For patients with open physes approaching skeletal maturity, transphyseal anterior cruciate ligament reconstruction (ACLR) with soft tissue autograft and metaphyseal fixation is often preferred. Although iatrogenic physeal injury is rare, growth disturbances have been...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Advances in Interventional Oncology for Hepatocellular Carcinoma

Locoregional therapies are used across the hepatocellular carcinoma (HCC) treatment spectrum, including for curative treatment of small tumors, as bridging or downstaging therapy before liver transplant, for treatment of intermediate-stage disease, and as part of combination trea...

Acute Effects of Impella 5.5 on Biventricular Filling and Pressure–Volume Area in Patients With Heart Failure Associated Cardiogenic Shock

Use of Impella 5.5 in patients with decompensated heart failure-associated cardiogenic shock (ADHF-CS) is increasing as a bridge to advanced therapies. The effects of maximal trans-valvular unloading on biventricular filling and pressure–volume area (PVA) in ADHF-CS are poorly un...

Retrograde Tibialis Anterior Artery Access as an Alternative Route for Stent-Based Endovascular Repair of Femoral Access-Site Complications

BackgroundFemoral arterial access can lead to complications, including bleeding, pseudoaneurysms, arteriovenous fistulas (AVFs), and dissections. When utilizing endovascular methods, the treatment of these complications is typically performed via contralateral femoral access. For...

Musculoskeletal MRI Relaxometry Phantom for T1 , T2 , and T1ρ Measurements

ABSTRACT Background Quantitative MRI (qMRI) requires quality assurance methods that reflect in vivo conditions to ensure consistent measurements with low bias and high reproducibility over time, across multiple sites, and across different MRI scanner manufacturers and models. Pur...

Patient–ventilator asynchronies beyond the waveform

PURPOSE OF REVIEW: Patient-ventilator asynchrony is commonly treated as a technical mismatch requiring correction, although asynchronous breaths are not uniformly harmful and apparent synchrony may conceal injurious effort. This review summarizes evidence from the past 18 months...

Citron kinase activity controls alternative splicing events that drive prostate cancer growth

Prostate cancer (CaP) remains a major cause of cancer death in men, underscoring the need for mechanistically novel therapies. We previously identified the action of the mitotic kinase citron (CIT) kinase as a key driver of CaP progression and promising therapeutic target, but se...

Brain volumetric signatures of neighborhood disadvantage in focal epilepsy

Abstract Objective Social disadvantage is an important determinant of health in focal epilepsy, but its neurobiological basis remains unclear. We examined whether brain morphometric alterations represent a structural signature of deprivation. Methods We performed a retrospective...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Deep whole genome sequencing of epileptogenic brain lesions

Abstract Objective Malformations of cortical development and low‐grade epilepsy‐associated tumors often cause drug‐resistant lesional focal epilepsy (LFE) amenable to surgical treatment. Genetic testing of resected brain tissue can provide diagnostic and mechanistic information a...

Phenotype‐Based Risk Stratification in Patients With New‐Onset Atrial Fibrillation Following Myocardial Infarction Using a Data‐Driven Approach

ABSTRACT Background Atrial fibrillation (AF) after myocardial infarction (MI) is associated with significant morbidity and mortality, yet existing risk stratification tools perform poorly in this population. Conventional predictors fail to capture multidimensional risk, while dat...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Perioperative and Periinterventional Platelet Function Testing

Abstract Purpose of the Review This review summarizes the current knowledge on the use of perioperative and periinterventional platelet function monitoring aiming to individualize antiplatelet therapy. Recent Findings In cardiac surgery, the recent guidelines recommend drug-speci...

Use of Vaginal Estrogen in Breast and Gynecologic Cancer Survivors

To review the safety, efficacy, and clinical considerations of vaginal estrogen therapy for the treatment of genitourinary syndrome of menopause (GSM) in patients with a history of breast or gynecologic cancer. This is a narrative review of the current literature and clinical gui...

A phase II pilot trial of an indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor (INCB024360) plus a multipeptide melanoma vaccine (MELITAC 12.1) in patients with advanced melanoma, with sequential evaluation of the tumor microenvironment

Indoleamine 2,3-dioxygenase-1 (IDO1) can mediate immune dysfunction by reducing tryptophan (Trp) and increasing kynurenine (Kyn). The CITN-04 clinical trial (NCT01961115) tested the safety and clinical activity of combination therapy with IDO1 inhibitor epacadostat (INCB024360) p...