Cincinnati Children's Hospital Medical Center

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

Impact of SGA, AGA, and LGA birthweight subclassification on NICU mortality risk identification: a cohort study

Abstract Objective To assess whether subdividing small (SGA, <10th), appropriate (AGA, 10th–90th), and large (LGA, >90th percentile) for gestational age (GA) birthweight classifications improves mortality risk estimation among preterm infants in neonatal intensive care units (NIC...

From timekeeping to divisions—Molecular links between circadian rhythms and cell cycle

Circadian rhythms and the cell cycle are two fundamental biological oscillators. They are linked through molecular mechanisms creating coupled oscillators where the outcomes of this coupling depend on numerous factors, such as the directionality of coupling (i.e., unidirectional...

Long-Term Follow-Up of Checkpoint Inhibitor-Associated Uveitis Treated with Fluocinolone Acetonide Intravitreal Implant in a Pediatric Patient

Purpose To describe the clinical course and 2-year follow-up of a pediatric patient treated with 0.18 mg fluocinolone acetonide intravitreal implants (Yutiq, EyePoint Pharmaceuticals) for chronic, bilateral immune checkpoint inhibitor (ICI)-associated uveitis.Methods Retrospectiv...

Perceptions of Secure Messaging and Patient Safety: Results of an Interprofessional Survey

BACKGROUND AND OBJECTIVES: Communication technology within pediatric health care systems is rapidly evolving and has the potential to affect safety culture. After implementing a secure messaging communication platform at our quaternary care hospital, we aimed to evaluate the new...

Trends in Regionalization of Pediatric Inpatient and Critical Care by Medical Complexity

BACKGROUND AND OBJECTIVES: Pediatric inpatient and critical care services are increasingly regionalizing: shifting from smaller hospitals to larger specialty centers. Children with medical complexity (CMC) and with technology dependence (TD) account for a disproportionate share o...

Siblings With Duchenne Muscular Dystrophy: Exploring Diagnosis Age and Disease Progression in a Genetic Therapy‐Naïve Cohort

ABSTRACT Introduction Duchenne muscular dystrophy (DMD) is the most common pediatric muscular dystrophy. Typically, there is a ~ 2‐year delay between symptom onset and diagnosis. Limited data on outcomes in early‐diagnosed individuals have limited the understanding of the clinica...

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug dis...

Moebius‐Plus Phenotype With Positive RCEM Episignature May Indicate Broader Embryologic Malformation Spectrum Detectable by Methylation Profiling

ABSTRACT Moebius syndrome (OMIM #157900) is a rare congenital cranial dysinnervation disorder characterized by abducens (CN VI) and facial (CN VII) nerve palsies with variable craniofacial and limb anomalies. Despite advances in genomic testing, the majority of patients remain ge...

Impact of post‐chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children’s Oncology Group AREN0532, AREN0533, and AREN03B2 studies

Abstract Background Improvements in therapy for patients with favorable histology Wilms tumor (FHWT) have relied on refinement of risk stratification for therapeutic assignment through identification of favorable and unfavorable prognostic factors. Although well established in In...

Interplay between fibroblast growth factor 9 (FGF9) and CD44 underlies 46,XY disorders of sex development in Kruppel‐like factor 1 (KLF‐1)‐E325K‐associated congenital dyserythropoietic anaemia (CDA‐IV)

Summary A heterozygous Kruppel‐like factor 1 (KLF1) E325K mutation causes a severe form of congenital dyserythropoietic anaemia (CDA), designated CDA‐IV (Online Mendelian Inheritence in Man, OMIM 613673), a rare disease with only 15 cases known. In addition to haemolytic anaemia,...

Increasing Rounds Participation for Caregivers Who Prefer a Language Other Than English

OBJECTIVES: For patients admitted to our hospital medicine resident services, we found that caregivers who were present at bedside and who preferred a language other than English (LOE) participated in family-centered rounds (FCRs) 53% of the time compared with 92% for English-pre...

A County-Level Collaboration to Reduce Infant Mortality: Cradle Cincinnati

OBJECTIVE: We sought to implement and determine the efficacy of Cradle Cincinnati-a county-level collective impact collaborative established to reduce the infant mortality rate (IMR) of Hamilton County, Ohio. We hypothesized that the reduction in the IMR of Hamilton County was at...

The Impact of Tablet-Based Screening on Trichomonas Testing in the Pediatric Emergency Department

OBJECTIVES: Sexually transmitted infections (STIs) are a public health concern for adolescents and young adults, with half of STIs diagnosed annually among 15 to 24-year-olds. Trichomonas vaginalis is a high-prevalence STI, linked with increased risk for HIV and premature births....

Response to Vibration‐controlled transient elastography in pediatric metabolic dysfunction‐associated steatotic liver disease: Considerations for risk stratification and clinical use

The authors declare no conflict of interest. Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

Landscape of approaches for streamlining pre-analytical and early analytical variables for solid tumor next-generation sequencing: A Genomics Organization for Academic Laboratories consortium report

The scope of pre-analytical and early analytical methods used in clinical molecular laboratories can have vast effects on the quality and turnaround time for solid tumor next-generation sequencing assays. To learn more about various approaches, a survey of 24 academic laboratorie...

CART-Cell Therapy in Pediatric Acute Lymphoblastic Leukemia: A Review for General Pediatricians

Chimeric antigen receptor (CAR) T cell therapy has transformed outcomes for children and young adults with relapsed/refractory CD19+ B-cell acute lymphoblastic leukemia (B-ALL), enabling deep remissions even in patients who are refractory to chemotherapy or have relapsed after he...

Burden and Risk Factors for Severe Respiratory Syncytial Virus Infection Among Pediatric Hematopoietic Cell Transplant Recipients

BACKGROUND: Respiratory syncytial virus (RSV) causes substantial morbidity in pediatric hematopoietic cell transplant (HCT) recipients; however, risk factors for severe disease remain incompletely characterized. METHODS: We conducted a multicenter retrospective cohort study acros...

Empowering leaders, empowering teams: fostering wellness through leadership

Pediatric radiology is deeply meaningful work, yet increasing workplace stress and burnout threaten workforce engagement, retention, and the delivery of high-quality patient care. Historically, many wellness initiatives have focused on individual-level interventions, such as resi...

Prescription Patterns of Cardiovascular Medications in the Adolescent and Adult Population With Fontan Circulation—A Report From the Multicenter Single Ventricle Outcomes Network

BACKGROUND: There are limited data on prescription patterns in adolescents and adults with Fontan circulation. METHODS: We conducted a retrospective analysis of patients 13 years of age and older enrolled between 2022 and 2024 in the Fontan Outcomes Network (now SV-ONE [Single Ve...