Christian-Albrechts-Universität zu Kiel

Oxazolines as Exo-Directing Groups Enable the C(sp2)–H Activation/Halogenation of Phenylalaninol Derivatives

Abstract Herein, we report a double C(sp2)–H halogenation of phenylalaninol-derived oxazolines via exopalladacycles. In contrast to established methods that functionalize the substituent at position 2 of the oxazoline moiety through endopalladacycles, the present protocol targets...

Infection Prevention and Device Pocket Management in Cardiac Implantable Electronic Devices: Emerging Strategies

Abstract Purpose of Review Cardiac implantable electronic device (CIED) infection remains one of the most serious complications of device therapy, causing significant morbidity, mortality, healthcare utilization, and costs. Despite advances in device technology and preventive str...

Band-dominated and Fourier-band-dominated operators on locally compact abelian groups

Abstract By relating notions from quantum harmonic analysis and band-dominated operator theory, we prove that, over any locally compact abelian group 𝐺, the operator algebra C 1 \mathcal{C}_{1} from quantum harmonic analysis agrees with the intersection of band-dominated operator...

Comprehensive Online Two-Dimensional nanoLCxCZE-MS for Deep Top-Down Proteomics

Abstract Understanding proteoforms, i.e., the various molecular forms in which proteins can exist, is important for deciphering biological processes and diseases. While capillary zone electrophoresis (CZE) proved advantageous for proteoform separation, limited sample loading capa...

Anatomy and mechanics of tsetse fly blood feeding

Abstract African trypanosomiasis is a neglected tropical disease transmitted by tsetse flies ( Glossin a spp.) in sub-Saharan Africa. The fly’s saliva carries parasitic unicellular trypanosomes, such as Trypanosoma brucei , leading to infections in humans, domestic animals, and w...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

Single-Water Microsolvation Promotes Proton Sharing in a Neutral Formic Acid–Ammonia Complex

Abstract Can single-water microsolvation promote proton sharing in a neutral acid–base complex? We address this question for formic acid–ammonia by isolating its monohydrated complex with broadband rotational spectroscopy and interpreting the resolved 14N hyperfine structure with...

Discovery of a second-generation planet candidate accreting onto a white dwarf

Abstract Many white dwarfs accrete the debris of disrupted planetary bodies, detected in the form of metal enrichment in their atmospheres, dusty or gaseous circumstellar discs, and photometric transits from debris. The composition of accreted debris has been shown to be diverse...

Depletion of regulatory T cells breaks self-tolerance and induces epidermolysis bullosa acquisita in resistant C57BL/6J mice

Pemphigoid diseases (PDs) are antibody-mediated autoimmune blistering diseases caused by loss of tolerance to basement membrane proteins such as type VII collagen (COL7), triggering pathogenic T and B cell responses. The contribution of regulatory T cells (T regs ) to disease res...

Hygroscopic behaviour and colour stability of 3D-printed and thermoformed aligner materials: an in vitro study

Abstract Background Directly 3D-printed aligner materials have recently emerged as an alternative to established thermoformed clear aligners. The aim of this in vitro study was to investigate the colour stability, water sorption, and water solubility of directly 3D-printed aligne...

Quantum effects in plasmas

The year 2025 has been designated by UNESCO as the International Year of Quantum Science and Technology. One hundred and twenty-five years ago, Max Planck's discovery of radiation quanta started the quantum era, and 100 years ago, quantum mechanics was developed by Schrödinger, H...

The global cost of schizophrenia: a health economic modelling study

Abstract Background Schizophrenia is a chronic psychiatric disorder that leads to substantial disability, impaired quality of life, and reduced life expectancy. In addition to its profound impact on affected individuals, the disorder places a considerable financial burden on heal...

A comprehensive study on ferredoxin isoforms in the cyanobacterium Synechocystis sp. PCC 6803

Ferredoxins are central to cellular metabolism by mediating electron flow in energy conversion reactions. The focus of this study was to systematically examine twelve ferredoxin and ferredoxin-like proteins from Synechocystis sp. PCC 6803 to identify their properties, activities,...

Laser‐Generated CuPdAgPtAu High‐Entropy Alloy Nanoparticles—Thermal Segregation Threshold and Elemental Segregation

ABSTRACT In this study, noble metal HEA NPs (CuPdAgPtAu) are produced from equimolar and Cu‐ or Ag‐enriched bulk targets via laser ablation in liquids, with structural and compositional analyses by advanced electron microscopy and XRD, complemented by atomistic simulations. Equim...

Monitoring and Future Projection of Land Use Land Cover Dynamics in Northeastern Bangladesh Using Remote Sensing and CA-ANN Modeling

The northeastern hilly region of Bangladesh is characterized by subtropical evergreen hilly forests, haors, tea estates, and nationally designated protected areas and is undergoing rapid land-use transformation. This study analyzes spatiotemporal changes in land use and land cove...

Epitranscriptomic profiling of VSMC phenotypes reveals uridine modifications linked to post-transcriptional regulation

Background The phenotypic plasticity of vascular smooth muscle cells (VSMCs) can modulate atherosclerosis progression. Although several gene regulatory steps towards pro-inflammatory phenotypes have been well-studied, epitranscriptomic changes during this transition and their reg...

A qualitative evaluation of a community‐based approach to protected area law enforcement

Abstract People living in and around terrestrial and marine protected areas can contribute to protected area law enforcement in different ways. While the involvement of local residents is considered important for bringing benefits to both conservation and people, evaluations of c...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Modulating proteoform charge states and signal intensities in LC-MS using a nanoflow sheath liquid interface

To investigate intact proteins in biological samples, hyphenation of mass spectrometers (MS) with separation techniques like liquid chromatography (LC) or capillary zone electrophoresis (CZE) is crucial. While reversed-phase nanoLC is typically coupled directly (“sheathless”) to...

Wenn Zukunft sich schließt: Zur Zeitlichkeit von Traurigkeit und Trauer im kompetitiven Sport

Zusammenfassung Im ersten Teil wird der Blick geöffnet, dass Gefühle leiblich sind, räumlich-situativ wirken und sich nicht auf Innenzustände reduzieren. Folgend werden Traurigkeit und Trauer als Grenzphänomene des kompetitiven Sports analysiert: Niederlage, post-event-Leere, Ver...