Christian-Albrechts-Universität zu Kiel

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

Moment Matching for Bayesian Inference in the Baseline New Keynesian Model

Abstract The sparsity and small size of economic samples often obscure the identification of parameters in macroeconomic models. These identification problems originate from the poorly defined mapping between a structural model and reduced-form parameters. Hence, researchers rely...

Prehistoric pottery styles of the Jutland Peninsula and their effect on human attention

Abstract This paper examines how long-term transformations in pottery styles from the Jutland Peninsula (Denmark) may relate to patterns of visual attention between 4600 and 1 BCE. Free-viewing eye-tracking experiments were designed to record participants’ engagement with differe...

Key management practices controlling yield performance and nitrate leaching in a grass-clover based organic crop rotation

Organic farming is frequently discussed as a strategy for mitigating nitrate leaching, especially in water protection areas. The effectiveness of nitrogen (N) management practices within organic crop rotations requires evaluation to balance yield performance with nitrate leaching...

Frailty before disease onset: risk of mortality and chronic conditions in disease-free middle-aged adults

Abstract Frailty, defined by multisystem physiological decline and heightened vulnerability to stressors, is typically associated with aging and chronic disease. However, its relevance in apparently healthy individuals remains poorly understood. Identifying frailty in this popula...

Identity fusion in children: A validation of the Dynamic Identity Fusion Index

Identity fusion is a strong form of group alignment, in which individuals experience a visceral sense of oneness with the group, motivating extreme forms of pro-group action. However, little is known about the emergence and development of identity fusion across the lifespan, larg...

Characterizing the intrinsic parameters, mass, volume and density, of single pollen grains as a base for mechanical analysis of pollen adhesion

MAIN CONCLUSION: This study combines own experimental data with an extensive literature research to characterize the average single pollen grain mass, volume and density as parameters for future force measurements on pollen. The analysis of pollen grain mechanical properties and...

Identification and phenotypic profiling of subgroups with distinct cognitive aging trajectories

Cognitive aging is shaped by genetic variation, environmental factors, and health-related conditions. Until now, it is largely unclear why some individuals maintain their cognitive function, and others show progressive cognitive decline. This study uncovered determinants of disti...

Capturing of interdental areas with digital and conventional impression systems and their impact on automatic tooth segmentation in CAD software: an in vitro study

OBJECTIVES: This in vitro study evaluated and compared the accuracy of digital versus conventional impression systems in reproducing interdental areas (IAs) of periodontally compromised dentitions (PCDs) and examined how impression quality influences automated tooth segmentation...

Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance

The gut microbiome has been implicated in the pathogenesis of food allergy (FA), prompting microbiome-focused interventions. We evaluated, in a phase 1 open-label trial (NCT02960074), the safety and efficacy of oral encapsulated fecal microbiome transplantation (FMT) in 15 adults...