Chongqing Emergency Medical Center

Effects of Polyphyllin I on Stem Cell Properties of MCF-7 Spheroids and Its Correlation With Hybrid Epithelial-Mesenchymal Transition.

cells.No significant changes were observed in key proteins of the intrinsic apoptosis pathway. Conclusions Polyphyllin I reshapes the hybrid EMT state in MCF-7 spheroids，which is accompanied by the disruption of their high stemness equilibrium.This compound may reduce cellular s...

Serum neutrophil elastase as a potential non-invasive biomarker for assessing hepatic fibrosis in chronic hepatitis B patients

The role of neutrophil elastase (NE) in liver fibrosis caused by chronic hepatitis B (CHB) has not been fully clarified. This study sought to measure serum NE concentrations in individuals with CHB and to determine whether NE could serve as a noninvasive indicator for assessing C...

A ROS-Responsive Photothermal Hydrogel for Tumor Microenvironment Reprogramming and STING-Mediated Immune Engagement

Photothermal therapy can induce local tumor cell death and trigger antitumor immune responses. However, its efficacy is often limited by insufficient lymph node immune priming and by sustained ROS generated from thermal stress, which suppress immune cell function. An oxidative-st...

Deep learning-powered virtual eosin-based elastic fiber framework imaging improves objective grading and prognostic stratification of lung adenocarcinoma

Histological grading of lung adenocarcinoma is limited by interobserver variability, particularly when distinguishing noninvasive lepidic growth from invasive patterns. This distinction depends on evaluation of the alveolar elastic fiber framework, which is often insufficiently v...

Resveratrol attenuates tubular injury in diabetic kidney disease by suppressing the ferroptosis–ferritinophagy pathway

Abstract Background Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease, and renal oxidative stress (OS)–mediated tubular injury plays a critical role in its progression. Resveratrol (Res) possesses established antioxidative properties, yet its mechanistic...

Integrative analysis of network pharmacology and machine learning suggests potential anti-colorectal cancer mechanisms of Taohong-Siwu decoction

Colorectal cancer (CRC) remains one of the most prevalent malignancies worldwide, characterized by high morbidity and poor prognosis. Although traditional Chinese herbal formulas have shown promising therapeutic potential, their multi-target mechanisms in CRC are still poorly und...

Global sustainable development trends reveal widespread inequality and tradeoffs

Progress towards the United Nations Sustainable Development Goals is usually assessed at the national scale, but national averages can hide local differences and trade-offs. Here we show a global assessment of sustainable development trends from 2000 to 2019 using high-resolution...