Chinese Academy of Sciences

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...

Deep N-glycoproteomic profiling of FFPE tissues enables precise diagnosis of primary liver cancer from metastatic liver cancer

Reliable tumor origin assessment from routinely archived specimens remains challenging, particularly for diagnostically ambiguous liver malignancies. Although formalin-fixed, paraffin-embedded (FFPE) tissues are widely available, deep and quantitative site-specific N-glycoproteom...

PCA–GPR-Assisted Sequential Bayesian Inversion of Slope Mechanical Parameters from Multi-Stage Deep Horizontal Displacement Monitoring

Reliable mechanical parameters are needed to predict deformation during staged slope excavation, yet deep inclinometer profiles are high-dimensional and repeated numerical inversion is costly. This study integrates principal component analysis, Gaussian process regression (GPR),...

CIP2A–TOPBP1 complex and PP2A dynamically regulate Polθ recruitment and phosphorylation at mitotic DNA double-strand breaks

DNA double-strand breaks (DSBs) that occur during mitosis are primarily repaired by Polθ-mediated microhomology-mediated end joining (MMEJ). The CIP2A–TOPBP1 complex has been shown to tether broken chromatin at mitotic DSBs, but whether it coordinates with or functions independen...

Urban water system resilience and risk assessment in a typical arid industrial city: a case study of Karamay

This study develops a multi-dimensional framework to assess urban water resource resilience and risk in Karamay, a typical resource-based industrial city in arid northwest China. By integrating long-term data on water supply and demand, meteorological and hydrological conditions,...

CFD-Based Simulation and Optimization of Summer Environmental Conditions in Laying Hen Houses

To address uneven temperature and relative humidity distributions, localized heat accumulation, and insufficient air velocity in an enclosed stacked-cage laying hen house, a three-dimensional computational fluid dynamics (CFD) model of the laying hen house was developed using fie...

Engineering and land use intensified climate-driven Yangtze River flood hazards since the Little Ice Age

Understanding the interplay between climate variability and human activities is essential for assessing long-term river flood hazards. Yet, the relative contributions of natural and anthropogenic drivers to flood magnitude remain poorly constrained due to limited multicentury rec...

Dynamic Resilience Screening of Strait of Hormuz-Induced Trade Squeeze in Global Food Supply Chain Systems

A maritime chokepoint shock can spread beyond the countries directly connected to the affected route. We develop a monthly resilience screening model for a hypothetical Strait of Hormuz closure that separates direct disruption, scarcity-driven trade squeeze, household access pres...

Detailed study of non-equilibrium characteristics of quasi-neutral TNSA plasmas

In an experiment performed in November 2022 at the petawatt (PW) laser facility at Vega III located in Salamanca-Spain, we have studied the successful production of several radioisotopes using protons accelerated by the Target Normal Sheath Acceleration (TNSA) mechanism (Rodrigue...

Influence Mechanisms of Spatial Optimization of the “Terraced Fields‐Gully Land Reclamation Project ( GLRP )” Cascades on Erosion‐Transportation Processes in Watershed in the Loess Hilly‐Gully Region of China

ABSTRACT Terraced fields and the Gully Land Reclamation Project (GLRP) are important soil and water conservation measures, widely constructed in China's Loess Plateau and other ecologically fragile areas in the world. However, under large‐scale governance scenarios, the impacts o...

Effects of Shade Treatments on Growth, Photosynthetic Performance, Leaf Microstructure, and Pigment Accumulation in Horsfieldia hainanensis Seedlings

In this study, three-year-old seed-derived seedlings of Horsfieldia hainanensis Merr. were subjected to 0%, 25%, 50%, and 75% shade treatments in a nursery shade-net experiment from October 2025 to June 2026. Each treatment included three replicates, with three seedlings per repl...

Reversibly Cross‐Linked Damage‐Tolerant Polymers Breaking the Strength–Stretchability Trade‐Off

ABSTRACT Polymers that combine exceptional stretchability with high mechanical robustness are essential for advanced applications. To ensure their reliability, it is critical to integrate damage tolerance, which suppresses crack propagation and prevents catastrophic failure under...

Reaction-induced surface/subsurface indium species formation on ZrO2 for enhanced CO2 hydrogenation to methanol

The complex structural evolution of oxide catalysts during CO2 hydrogenation presents both challenges and opportunities for optimizing catalytic performance. This study demonstrates reaction-induced transformation of In2O3 particles into InOx nanolayers and subsurface In-Zr-O sol...

Interspecific interactions alter survival strategies of tree-shrub plants and hinder treeline ascent at alpine treelines in Southeastern Tibet: Evidence from13C and15N.

-N), and this preference increased in mixed communities for both species, with the increase in R. nivale substantially greater than that in J. saltuaria. (2) Within mixed communities, the inorganic nitrogen uptake rates of leaves, branches, and fine roots in R. nivale were signif...

Enhancing the WAS physical hydrological model and integrating machine learning and residual decomposition to improve runoff simulation performance in the cold region of the Taoerhe River Basin, Northeast China

Study region: The Taoerhe River Basin, located in Northeast China. Study focus: Physical hydrological models still have limitations in representing runoff processes in seasonally frozen semi-arid basins. This study improved runoff simulation through physical model modification an...

X‑ray computed tomography‑based experimental investigation of CO₂ miscible zone formation mechanisms and degree of miscibility

Carbon dioxide capture, utilization, and storage–enhanced oil recovery (CCUS–EOR) depends on the progressive development of CO₂–oil miscibility, yet the pressure-controlled transition from interfacial mass transfer to porous-media miscible-zone propagation remains difficult to qu...

Optimizing Tribological Performances and Corrosion Resistance of (TiNbCrZrMo)N x High‐Entropy Nitride Coatings via Substrate Bias Modulation

To meet the corrosion protection and lubrication requirements of mechanical transmission components in marine environments, this paper is dedicated to designing a (TiNbCrZrMo)N x high‐entropy nitride (HEN) coating by magnetron sputtering deposition and optimizing its tribological...

65 TOPS optoelectronic multi-core computing unlocking multi-feature fusion enhancement

The rapid progress of artificial intelligence demands scalable, energy-efficient hardware with massive parallelism and high throughput. Although optical computing offers a promising post-Moore solution, current implementations face speed limitations and multi-core integration cha...

All-Optically Controlled Memristive Reservoir Computing Capable of Bipolar and Parallel Coding

Physical reservoir computing (RC) utilizes intrinsic dynamics of physical systems for efficient data processing. Emerging optoelectronic RC platforms merge the benefits of electronic and photonic computation. However, conventional designs are constrained by the unipolar photoresp...