China Medical University

Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework

Inherited mitochondrial cardiomyopathies arise from pathogenic variants affecting oxidative phosphorylation, mitochondrial DNA maintenance, cardiolipin remodeling, protein import, cofactor metabolism, and mitochondrial dynamics or proteostasis. These disorders may be cardiac-pred...

Chinese herbal medicine therapy reduces all-cause and cardiovascular disease-related mortalities in acquired hemolytic anemia: A Taiwanese nationwide retrospective cohort study

Objectives To assess whether Chinese herbal medicine (CHM) treatment was associated with all-cause and cardiovascular disease (CVD)-related mortality in Taiwanese patients with acquired hemolytic anemia (AHA). Design & setting This population-based retrospective cohort analysis u...

scTransMIL bridges patient-level disease states and single-cell transcriptomics for cancer screening and heterogeneity inference

Single-cell sequencing offers profound insights into tumor complexity. However, reliably linking individual cellular profiles to overall sample-level phenotypes remains computationally challenging, particularly when cell-specific annotations are absent. This disconnect limits the...

Campylobacter jejuni genotoxin promotes intestinal inflammation via the DNA damage-cGAS-STING signaling axis

The foodborne agent Campylobacter jejuni is a pervasive zoonotic pathogen and a major cause of gastrointestinal disease associated with inflammatory disorders in humans. While its genotoxin, cytolethal distending toxin (CDT), induces DNA damage, the toxicological signaling events...

Phytochemical-capped silver nanoparticles as functional antiviral nanomaterials: Computational and experimental analysis of nano–bio interactions with SARS-CoV-2 targets

The emergence of SARS-CoV-2 variants highlights the need for antiviral strategies integrating molecular inhibitors and nanostructured materials. This study employed a computational and network pharmacology approach to investigate clinically approved SARS-CoV-2 protease inhibitors...

Automated CT-Based Quantification of Pulmonary Fibrosis Using Deep Learning-Based Lung Segmentation

Background/Objectives: To develop and evaluate an automated CT-based framework for the quantitative assessment of fibrotic interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), using a standardised six-level anatomical protocol and deep-learning lung seg...

Selectivity Filter KCND3 Variant Causes Spinocerebellar Ataxia 19/22 and K V 4 .3 Functional Loss

Abstract Background Spinocerebellar ataxia type 19/22 (SCA19/22) is a rare autosomal dominant neurodegenerative disorder caused by KCND3 variants encoding the K V 4.3 potassium channel. While most pathogenic variants result in loss‐of‐function (LOF), no pathogenic variants were p...

Machine Learning Model for Predicting Hepatocellular Carcinoma Development in Patients With Hepatitis B Virus‐Related Cirrhosis Receiving Antiviral Therapy

Few prediction models have been specifically designed to evaluate the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B and cirrhosis. This study aimed to develop a machine learning-based prediction model to assess the risk of developing HCC in patients...

Effect of APOE and LPA genotypes on the risk of dementia after myocardial infarction: a clinic-based cohort study

Survivors of myocardial infarction (MI) face elevated risk of subsequent cognitive decline, yet the relative contributions of neurodegenerative susceptibility ( APOE4 ) and lipid-mediated vascular burden ( LPA risk variants) to post-MI dementia remain unclear, particularly in Asi...

Hepatitis B virus reactivation risk in haploidentical versus matched donor transplantation: Impact of universal prophylaxis

Background Hepatitis B virus reactivation is a serious complication of allogeneic hematopoietic cell transplantation, particularly in endemic regions. Patients with HBsAg-negative/anti-HBc-positive serology represent an intermediate-risk group due to occult hepatitis B virus infe...

Polyphenol-rich jaboticaba (Myrciaria cauliflora) seed extract confers neuroprotection and extends lifespan in Drosophila through enhanced antioxidant and anti-inflammatory capacity

Myrciaria cauliflora (jaboticaba) is widely recognized for its polyphenol-rich fruit; however, its seeds are typically discarded and remain largely underexplored despite their potential bioactive value. This study investigated the effects of different extraction conditions on the...

Beyond Caregiving: Recovery and Growth Among Primary Caregivers Following the Loss of a Family Member Living With Dementia

BACKGROUND: Caring for a family member with dementia places long-term emotional, physical, and social strain on primary caregivers. Although extensive research has examined the caregiving phase, relatively few studies have explored caregivers' recovery experiences following berea...

scProtoTransformer: Scalable reference mapping across molecules, cells, and donors

Abstract The rapid accumulation of single-cell data has made it possible to comprehensively characterize biological systems at molecular, cellular, and donor levels. However, scalable reference mapping across different resolutions remains a major challenge in current research. He...

P1.126. Synchronous Head and Neck Squamous Cell Carcinoma and Esophageal Squamous Cell Carcinoma Treatment Experience From CMUH

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Esophageal squamous cell carcinoma account for 53% of esophageal tumor has high mortality due to exposure of carcinogens in Asian country. Head and neck cancer had high synchronous association with esophageal...

Temporal patterns and risk factors of clozapine-associated neutropenia: a nationwide population-based cohort study

Background Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, but neutropenia concerns continue to limit its use. Large real-world evidence on temporal risk patterns, re-initiation, and patient-level determinants remains limited. Methods We condu...

Beyond Central Subfield Thickness: Early Multi-Slice Optical Coherence Tomography Structural Response After Faricimab Injection in Real-World Diabetic Macular Edema

Objectives: We sought to evaluate the early efficacy of faricimab (Vabysmo®) in treating diabetic macular edema (DME) and to explore the predictive value of multi-slice optical coherence tomography (OCT) biomarkers for anatomical and visual outcomes. Methods: In this retrospectiv...

Prevalence of dementia and BPSD in community-dwelling older adults with advanced care needs: a nationwide survey in Taiwan

Background Caring for people with both dementia and advanced care needs is complex. This study aimed to elucidate the prevalence of dementia and behavioral and psychological symptoms of dementia (BPSD) in patients receiving advanced care, including tube feeding, respiratory care,...

Glycemic and Lipid Outcomes Associated with Bitter Melon Blood-Sugar-Modulating Protein and Metformin Use: A Translational Preclinical and Retrospective Study

Background/Objectives: Interactions between botanical supplements and standard antidiabetic therapies remain poorly understood. This study investigated the efficacy and mechanistic properties of a bitter melon blood-sugar-modulating protein (BMP) in relation to concurrent metform...

Associations between impaired intrinsic capacity and emergency room visits among community-dwelling older adults

Background Emergency room (ER) visits in older adults are associated with increased morbidity and mortality. The World Health Organization’s Integrated Care for Older People (ICOPE) framework assesses intrinsic capacity (IC), but the association between IC impairments and ER visi...

Risk of Dementia after initiation of GLP-1 RA versus long-acting insulin in patients with type 2 Diabetes mellitus

Background Recent studies suggest a decreased risk of dementia in patients treated with glucagon-like peptide-1 receptor agonist (GLP-1 RA). In this study, we compare the risk of dementia associated with GLP-1 RA versus long-acting insulin in adults aged over 50 years with type 2...