China Medical University

P1.126. Synchronous Head and Neck Squamous Cell Carcinoma and Esophageal Squamous Cell Carcinoma Treatment Experience From CMUH

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Esophageal squamous cell carcinoma account for 53% of esophageal tumor has high mortality due to exposure of carcinogens in Asian country. Head and neck cancer had high synchronous association with esophageal...

Temporal patterns and risk factors of clozapine-associated neutropenia: a nationwide population-based cohort study

Background Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, but neutropenia concerns continue to limit its use. Large real-world evidence on temporal risk patterns, re-initiation, and patient-level determinants remains limited. Methods We condu...

Beyond Central Subfield Thickness: Early Multi-Slice Optical Coherence Tomography Structural Response After Faricimab Injection in Real-World Diabetic Macular Edema

Objectives: We sought to evaluate the early efficacy of faricimab (Vabysmo®) in treating diabetic macular edema (DME) and to explore the predictive value of multi-slice optical coherence tomography (OCT) biomarkers for anatomical and visual outcomes. Methods: In this retrospectiv...

Prevalence of dementia and BPSD in community-dwelling older adults with advanced care needs: a nationwide survey in Taiwan

Background Caring for people with both dementia and advanced care needs is complex. This study aimed to elucidate the prevalence of dementia and behavioral and psychological symptoms of dementia (BPSD) in patients receiving advanced care, including tube feeding, respiratory care,...

Glycemic and Lipid Outcomes Associated with Bitter Melon Blood-Sugar-Modulating Protein and Metformin Use: A Translational Preclinical and Retrospective Study

Background/Objectives: Interactions between botanical supplements and standard antidiabetic therapies remain poorly understood. This study investigated the efficacy and mechanistic properties of a bitter melon blood-sugar-modulating protein (BMP) in relation to concurrent metform...

Risk of Dementia after initiation of GLP-1 RA versus long-acting insulin in patients with type 2 Diabetes mellitus

Background Recent studies suggest a decreased risk of dementia in patients treated with glucagon-like peptide-1 receptor agonist (GLP-1 RA). In this study, we compare the risk of dementia associated with GLP-1 RA versus long-acting insulin in adults aged over 50 years with type 2...

Associations between impaired intrinsic capacity and emergency room visits among community-dwelling older adults

Background Emergency room (ER) visits in older adults are associated with increased morbidity and mortality. The World Health Organization’s Integrated Care for Older People (ICOPE) framework assesses intrinsic capacity (IC), but the association between IC impairments and ER visi...

Exosomes as Emerging Therapeutic and Diagnostic Platforms: Biological Functions, Clinical Applications, and Translational Challenges

Exosomes are small membrane-bound extracellular vesicles of endosomal origin that play pivotal roles in intercellular communication by transferring proteins, lipids, metabolites, and nucleic acids. Increasing evidence indicates that these vesicles participate in diverse physiolog...

Martian‑Regolith Simulant Confined Nanogenerators for Wireless Tactile Sensing for Human‐Machine Interface

Achieving a sustainable energy system for space missions remains challenging due to the continued reliance on Earth-supplied materials. This underscores the importance of in situ resource utilization (ISRU) strategies that convert planetary resources into functional electronic co...

Sulfated PSGL-1 primes the enterovirus A71 fivefold vertex for localized remodeling

Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease and poses a significant public health threat through severe neurological complications in pediatric cases. P-selectin glycoprotein ligand-1 (PSGL-1) functions as an attachment factor, yet the structural basis of PSGL-1...