China Medical University

Thermal-economic performance assessment of heat recovery-oriented design of integrated CCHP-H₂ system; multi-objective optimization with LCA and AdaBoost decision-making

Combined cooling, heating, power systems integrated with hydrogen production (CCHP–H₂) can simultaneously supply useful outputs while improving the utilization of fuel and recoverable thermal energy. The present project proposes a methane-fueled CCHP–H₂ configuration integrating...

Sfp1 Contributes to Fluconazole Responses and Virulence in Candida albicans

Candida albicans is an important human fungal pathogen. Previous studies have shown that the transcription factor Sfp1 is involved in regulation of various biological processes in C. albicans, including cell wall maintenance, biofilm formation, oxidative stress responses, and car...

Value perceptions and implementation priorities for public PHR adoption in Taiwan: an importance–performance analysis with the Chuchiming Index

Abstract Background Value perceptions of personal health record (PHR) components at the pre-adoption stage remain underexplored, despite their critical role in promoting the adoption of public PHRs. Importance–Performance Analysis (IPA) may have limitations in identifying priorit...

Chiral Solid-State Nanopores Amplify Secondary Interactions for Ionic-Current Discrimination of Neurotransmitter Enantiomers

Abstract Single-molecule ionic-current sensing provides a powerful electroanalytical route for resolving small-molecule enantiomers, yet reliable discrimination remains difficult when stereochemical differences generate only weak and transient interfacial interactions. Here, we e...

Coderivatives with Respect to a Set of the Normal Cone Mappings and Their Applications

Abstract. Establishing explicit formulas of coderivatives with respect to a set of the normal cone mapping to a polyhedron, the solution set of a variational inequality system, is one of the main goals of this paper. By using our coderivative formulas, we provide a characteristic...

Standardized Short-Wave Infrared Hyperspectral Imaging for Non-Destructive Spectral Comparison of Coin Denominations, Design Variants, and Surface-Use Conditions

Coins contain multiple types of information, including denomination, design variant, year of issue, and surface condition. This study established a standardized 900–1700 nm short-wave infrared hyperspectral imaging (SWIR-HSI) workflow for controlled and non-destructive spectral c...

Treatment-Free Interval as a Prognostic Factor for Survival Outcomes in Patients with Advanced or Recurrent Endometrial Cancer Treated with Pembrolizumab Plus Lenvatinib: A Multi-Institutional Real-World Cohort Study

Background/Objectives: The treatment-free interval (TFI) predicts benefit from platinum rechallenge in gynecological cancers, but its prognostic value in patients receiving second-line pembrolizumab plus lenvatinib for recurrent endometrial cancer (EC) is unknown. We evaluated wh...

Progressive Conduction System Disease Preceding Hypertrophy in IVS4 + 919G > A Fabry Variant: a Population-based Electrocardiographic Study

BACKGROUND: The IVS4 + 919G > A variant is the most prevalent late-onset Fabry variant in East Asian populations, but its electrophysiological trajectory remains incompletely defined. METHODS: From a regional genetic screening program, 905 IVS4 + 919G > A carriers were identified...

IL33 gene polymorphisms and circulating IL-33 levels in pituitary adenoma: a case–control study

Abstract Pituitary adenoma (PA) is common intracranial tumor in which inflammatory mechanisms may contribute to tumor development and progression. Interleukin-33 (IL-33), an immune-related cytokine, has been implicated in tumor-associated inflammation; however, its role in pituit...

Frontline bevacizumab in ovarian clear cell versus high-grade serous ovarian cancer: survival outcomes and recurrence patterns in a real-world cohort

Ovarian clear cell carcinoma (OCCC) is associated with inferior survival compared to high-grade serous ovarian cancer (HGSOC), largely due to its relative chemoresistance and near-universal BRCA wild-type status. Whether frontline bevacizumab can mitigate this survival disadvanta...

Association of allergic rhinitis with polysomnographic arousal indices in children with sleep-disordered breathing

Abstract Background Children with allergic rhinitis (AR) frequently experience sleep disruption and have a higher prevalence of sleep-disordered breathing (SDB). However, the specific impact of AR on sleep architecture across different SDB subtypes, such as obstructive sleep apne...

Prognostic significance and molecular implication of microRNAs in hepatocellular carcinoma following curative surgical resection

Although various advanced therapeutic strategies exist for hepatocellular carcinoma (HCC), it continues to rank among the primary drivers of cancer-related fatalities worldwide. Resection surgery offers a cure for HCC, but a high recurrence rate severely limits patient survival....

Sex differences in the associations of body composition and PPARGC1A genetic variants with elevated pulse pressure

Pulse pressure (PP) is a hemodynamic marker for vascular aging. We investigated the sex-specific associations of bioelectrical impedance analysis (BIA)-derived body composition indices and PPARGC1A/VDR variants with elevated PP risk. This community-based study analyzed 5,829 adul...

Single versus triple low-molecular-weight hyaluronic acid injection strategies with shockwave therapy for rotator cuff lesions: A randomized study with an exploratory historical comparator

Background Rotator cuff lesions without full-thickness tear commonly cause shoulder pain and functional limitation. Hyaluronic acid (HA) injections and extracorporeal shockwave therapy (ESWT) are widely used conservative treatments, but the optimal HA dosing strategy combined wit...

Myostatin‐dependent detrusor remodelling mediates contractility impairment in diabetic rats’ bladder – a maximal elastance analysis

Abstract The role of myostatin, an endogenous myokine mediating the pathological progression of myopathy, in contractility impairments of the chronically diabetic bladder remains unclear. This study examined whether maximal elastance (mE) reliably and validly assesses bladder con...

High‐Resolution IVIM MRI Characterizes Diffusion–Perfusion Properties of the Parasagittal Dura

The objectives of this study were to characterize the diffusion-perfusion properties of the parasagittal dura (PSD) using high-resolution intravoxel incoherent motion (IVIM) MRI and to explore whether PSD-specific IVIM metrics reflect distinct fluid-transport-related signal behav...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework

Inherited mitochondrial cardiomyopathies arise from pathogenic variants affecting oxidative phosphorylation, mitochondrial DNA maintenance, cardiolipin remodeling, protein import, cofactor metabolism, and mitochondrial dynamics or proteostasis. These disorders may be cardiac-pred...

Telephone sequence spaces and associated theory of matrix transformation and compactness

Given a non-negative integer k, T_k be the k^{th} telephone number. Let us define a matrix T=( T_{k,m} ) with entries for k,m=0,1,2,⋯. Based on T, the matrix domains T_0 and T_c are defined. Schauder bases are constructed for these spaces, and their α-, β-, and γ-duals are charac...

Chinese herbal medicine therapy reduces all-cause and cardiovascular disease-related mortalities in acquired hemolytic anemia: A Taiwanese nationwide retrospective cohort study

Objectives To assess whether Chinese herbal medicine (CHM) treatment was associated with all-cause and cardiovascular disease (CVD)-related mortality in Taiwanese patients with acquired hemolytic anemia (AHA). Design & setting This population-based retrospective cohort analysis u...