Chiba University

OA03-RF01.11. Elucidation of the Function of Proline Isomerase Pin1 on Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Esophageal squamous cell carcinoma (ESCC) shows limited response to anti-PD-1 monotherapy, prompting interest in combination treatments. Pin1, highly expressed in ESCC and other cancers, drives malignancy. S...

P1.118. Delaying the Treatment Schedule in First-Line Chemotherapy Including ICIs for Esophageal Cancer Does Not Affect Survival Outcomes

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Cancer immunotherapy has dramatically changed the management of esophageal cancer. However, the impact of treatment delays on survival outcomes in first-line chemotherapy for esophageal squam...

Little Red Dots host Black Hole Stars: A unified family of gas-reddened AGN revealed by JWST/NIRSpec spectroscopy

Abstract We construct and characterise a sample of 146 little red dots (LRDs) across 2.0 < z < 9.3, selecting all sources with v-shaped UV-optical continua from JWST NIRSpec/PRISM spectra and compact morphologies in NIRCam/F444W imaging. We show that LRD continuum spectra are wel...

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used singl...

Preoperative computed tomography measurement for predicting difficulty in hand-sewn ileal pouch-anal anastomosis: a refined single-center cohort study

Restorative proctocolectomy with a hand-sewn ileal pouch-anal anastomosis (IPAA) is a standard treatment for ulcerative colitis and familial adenomatous polyposis. However, achieving sufficient mesenteric length remains a significant challenge. This study aimed to validate the po...

Serum anti-POTEE antibodies as a novel serological biomarker for early detection and prognostic stratification in gastrointestinal cancers

Abstract Background Given the highly aggressive nature of gastrointestinal cancers, the identification of novel biomarkers for diagnosis and prognosis is of considerable clinical importance. Methods Candidate cancer-testis (CT) antigens were first screened using RNA-sequencing da...

Machine-Learning Analysis of the Electronic Structure of Atomically Thin MnTe Films from Scanning Tunneling Spectroscopy

Layered two-dimensional (2D) van der Waals magnetic crystals based on 3d transition metals and chalcogenides are typically synthesized by chemical vapor transport, while establishing epitaxial, layer-by-layer growth under vacuum remains essential for device applications. Here, we...