Chengdu Medical College

Latent profiles and influencing factors of missed nursing care among ICU nurses

Abstract Background Missed nursing care (MNC) is common in intensive care units (ICUs) and seriously threatens patient safety. Most existing studies treat ICU nurses as a homogeneous group, overlooking within-group heterogeneity. Based on the Job Demands-Resources model, this stu...

Global research landscape of natural medicines for lower urinary tract symptoms: bibliometric and clinical trial analysis

Abstract Background Natural medicines have demonstrated significant therapeutic potential in the management and attenuation of lower urinary tract symptoms (LUTS). According to the Web of Science Core Collection (WoSCC), a total of 497 related articles have been published during...

A Cross‐Kingdom Counter‐Mimicry Nanozyme Reverses Fungal‐Induced Neutrophil Paralysis and Establishes Protective Immune Memory

ABSTRACT Recurrent fungal infections caused by Candida albicans remain a formidable clinical challenge due to the pathogen's sophisticated orchestration of immune evasion. Herein, we report a “kill‐and‐reset” nano‐platform comprising a CuFe dual‐atom nanozyme core encapsulated wi...

Tumor–host metabolic interactions in the microenvironment and macroenvironment: Mechanisms and targeting strategies

ABSTRACT: Tumor metabolic reprogramming is a hallmark of cancer and is driven not only by intrinsic mechanisms of tumor cells but also by dynamic interactions between the local tumor microenvironment (TME) and the host macroenvironment. This review systematically elaborates on th...

Multimodal nanomedicine for precision colorectal cancer management: integrated diagnosis, targeted therapy, and personalized theranostics

Colorectal cancer (CRC) imposes a substantial health burden because of its high incidence and mortality. Despite advances in surgical procedures, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, the overall efficacy is still unsatisfactory, especially for advanced...

A study on the screening of potential biomarkers for rheumatoid arthritis based on nontarget metabolomics

To explore changes in blood metabolites with rheumatoid arthritis (RA) using non-targeted metabolomics techniques, to identify potential metabolic biomarkers in RA patients. Twenty patients with rheumatoid arthritis (RA group) who attended the Sichuan Province Orthopaedic Hospita...

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

ABSTRACT The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed a...

Construction of In Vitro-In Vivo Correlation (IVIVC) Degradation Evaluation Model of Absorbable PCL/β-TCP Alveolar Bone Repair Scaffold and Exploration of a Biosafety Evaluation Idea Based on “Homeostasis”

Abstract Traditional in vivo degradation assessments for resorbable medical devices face challenges due to extreme durations, high costs, and a lack of criteria for reaching tissue-response steady states. This study investigates a 3D-printed PCL/β-TCP bone grafting scaffold by de...

Recent Advances in Comprehending Endothelial Dysfunction and Diabetic Cardiomyopathy: From Molecular Mechanisms to Clinical Applications

Diabetic cardiomyopathy (DCM) is a cardiac condition characterized by various structural and functional abnormalities that are associated with diabetes mellitus. Its development involves multiple factors, among which endothelial dysfunction plays a significant role. To fully desc...

Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma

Abstract Clear cell renal cell carcinoma (ccRCC) exhibits a paradoxical fructose metabolism signature characterized by upregulation of the fructose transporter GLUT5 alongside downregulation of the catabolic enzymes (ketohexokinase, aldolase B, and triokinase), a pattern associat...

Engineered desialylated platelet membrane camouflaged liposomes for the regulation of kupffer cells and hepatic stellate cells in treatment of liver fibrosis

The intercellular crosstalk and reciprocal activation between Kupffer cells (KCs) and hepatic stellate cells (HSCs) are critical drivers of liver fibrosis progression. Nonetheless, the co-regulation of KCs and HSCs is hindered by their distinct anatomical locations and the pathol...

Causal association between air pollution and functional outcome after ischemic stroke: Evidence from 2-sample MR study

Observational studies have shown that air pollution may affect functional outcome following ischemic stroke. Our study aimed to explore the relationship between genetically predicted specific air pollutants and poststroke functional outcomes using the Mendelian randomization (MR)...

Quantitative Evaluation of Cervical Spine Morphometry: Zero Echo Time MRI Versus Multislice CT

BACKGROUND: For preoperative cervical assessment, both CT and MRI are often required for bony and soft-tissue evaluation, yet CT entails radiation and MRI poorly depicts cortical bone. ZTE offers CT-like contrast in one examination, but whether it correlates with CT for quantitat...

Impact of IL-6 receptor inhibitors on cerebrospinal fluid metabolites in type 2 diabetes patients

This study aimed to investigate whether interleukin-6 (IL-6) receptor inhibitors affect cerebrospinal fluid (CSF) metabolites in type 2 diabetes (T2D) patients. The initial phase employed drug-targeted Mendelian randomization to investigate the association between IL-6 receptor i...

Research on the dynamic evolution of competitive and water-film-mediated wear mechanisms of the carbon strips in the pantograph-catenary system at low temperature

Abstract To investigate the evolution of wear mechanisms in carbon strips at low temperature, this study conducted comparative friction tests on copper-impregnated carbon strips at room temperature (25 °C) and low temperature (-20 °C). To replicate operating conditions, the exper...

Mechanisms of ferroptosis in Echinococcus granulosus cyst fluid-induced hepatic injury and the protective role of Nrf2 activation

Cystic echinococcosis (CE) is a globally distributed parasitic zoonosis caused by infection with Echinococcus granulosus. This study investigated the ferroptosis mechanism in hepatocyte injury induced by Echinococcus granulosus cyst fluid (EgCF) and its relationship with the nucl...

Longitudinal dynamics of the maternal gut virome associate with metabolic features of preterm birth

Preterm birth (PTB) remains a major pregnancy complication, yet the role of the maternal gut virome in its etiology is largely unknown. Here we show that the maternal gut virome undergoes ecological destabilization prior to PTB, coupled with distinct host metabolic remodeling. Ne...