Chengdu Medical College

Paraclostridium bifermentans S1-GT1 spores: a novel approach for oncolytic therapy

The core regions of solid tumors are characterized by hypoxia, which limits the efficacy of conventional therapies. Anaerobic bacterialspores represent a promising therapeutic strategy because they can germinate and proliferate in hypoxic regions. This study evaluatedthe antitumo...

ARMCX3 Regulates Breast Cancer Progression and Cisplatin Responsiveness Through p53-Related Signaling

Despite substantial advances in diagnosis and treatment, breast malignancy continues to cause considerable morbidity and mortality. Cisplatin has demonstrated therapeutic activity in selected patients with advanced breast cancer, but its clinical use may be limited by treatment r...

Infectious Bronchitis Virus Infection Induces Ferroptosis-Associated Changes with Lipid Peroxidation Dysregulation and Modulates Viral Replication

Infectious bronchitis virus (IBV) causes significant disease in poultry; however, whether ferroptosis-associated responses are involved in IBV-induced cellular injury remains unclear. In this study, we examined ferroptosis-associated changes in the HD11 chicken macrophage cell li...

Body roundness index and other anthropometric indices in relation to incident myocardial infarction: a cohort study from the UK Biobank

Traditional anthropometric measures like body mass index (BMI) and waist circumference (WC) inadequately reflect body fat distribution. Body roundness index (BRI), a derived anthropometric index mathematically equivalent to waist-to-height ratio (WHtR) after removing non-function...

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highl...

Oncolytic Virus-like Nanoparticle Targets the Golgi Apparatus via Sphingomyelin

Abstract The Golgi apparatus (GA) has emerged as a promising target for cancer therapy. Commonly, therapeutics are guided to the GA by recognizing specific receptors on the GA membrane. However, the low and heterogeneous expression of these receptors often results in suboptimal t...

Genetic risk factors and causal associations with sudden cardiac arrest

Sudden cardiac arrest (SCA) is a major cause of mortality, with complex etiology involving multiple genetic and environmental factors. In this study, we aimed to identify genetic risk factors for SCA and evaluate their causal associations using Mendelian randomization (MR) analys...

Arterial‐Ventricular Coupling Strain Index as an Independent Predictor of 10‐Year ASCVD Risk in Diabetic‐Hypertensive Patients

BACKGROUND AND AIMS: The combination of diabetes mellitus and hypertension significantly increases the risk of cardiovascular diseases (CVD). This study aimed to evaluate the association between ventricular-arterial coupling and the 10-year atherosclerotic cardiovascular disease...

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

ABSTRACT Limited aqueous dispersibility and potential off‐target toxicity hinder the development and clinical translation of proteolysis‐targeting chimeras (PROTACs). Herein, a bioactive self‐delivering “Split Nano‐Assembly of Photosensitizers and Targeting Chimeras” (SNAP‐TAC) t...

Stage-specific nanotherapeutics for glaucoma target elevated IOP, impaired aqueous-humor outflow, RGC degeneration, and fibrotic inflammation during postoperative wound healing

Glaucoma is a chronic neurodegenerative disease in which elevated intraocular pressure (IOP), impaired aqueous-humor outflow, retinal ganglion cell (RGC) degeneration, and postoperative fibrosis may coexist or predominate at different stages. Conventional therapies are effective...

Sandwich structured Ω-shaped fiber optic-based sensor with dual signals for simultaneous temperature and refractive index detection

Measurements of refractive index (RI) and temperature play a vital role in a wide range of applications. Nevertheless, cross-sensitivity remains a major obstacle when RI and temperature need to be measured simultaneously. In this study, a novel sandwich structured Ω-shaped fiber...

Resiquimod Improves the Tumor Accumulation and Antitumor Activity of SN38 Prodrug-Loaded Liposomes

Abstract The effectiveness of liposome-based antitumor drugs is significantly limited by the poor tumor accumulation of liposomes. Herein, we report that resiquimod (R848) can selectively increase tumor accumulation of 7-Ethyl-10-hydroxycamptothecin (SN38)-loaded liposomes (SN38-...

Trajectories of memory function before and after cardiovascular disease among hypertensive patients

The trajectories of cognitive function before and after cardiovascular disease (CVD) have been widely explored in the general population, but less is known in hypertensive patients who are regarded as the most vulnerable patients for both CVD and dementia. The cohort study was co...

Multilevel factors predicting medication adherence among gout patients in China

Adherence to urate-lowering therapy (ULT) is crucial for gout management, yet it remains suboptimal worldwide, particularly in China where relevant data are scarce. This study investigates the prevalence and predictors of medication adherence among Chinese gout patients receiving...

A pH-Responsive Ceria-Supported Iridium Clusterzyme for Combined Antibacterial and Anti-inflammatory Therapies in Diabetic Wound Healing

Abstract The treatment of diabetic wounds is hindered by multiple factors, including Staphylococcus aureus (S. aureus) biofilms (the predominant pathogen in diabetic wound infections), dysregulated immune responses, and insufficient angiogenesis. The complex interactions among th...

Influence of operating parameters on blade wear characteristics of helical vane multiphase pump

To address blade wear of helical vane multiphase pumps during sand-containing crude oil transportation in desert oilfields, a self-developed multi-stage pump was studied via numerical simulation (Discrete Phase Model, DPM) and experimental verification. The effects of flow rate,...

Case report: septal radiofrequency ablation for sigmoid ventricular septum-related dynamic obstruction: with observations suggesting left bundle branch block as a potential therapeutic collaborator

Abstract Background Sigmoid ventricular septum (SVS) can cause dynamic left ventricular outflow tract obstruction (LVOTO) during stress. Radiofrequency ablation (RFA) has been used for septal reduction in hypertrophic obstructive cardiomyopathy, but its application in SVS is limi...

Design of Dancing Robot Based on Machine Vision

Aiming at the application requirements of artificial intelligence and robotics, this paper adopts a lightweight and low-cost scheme to construct a dancing-robot system integrating machine vision, mechanical structure and motion control so as to improve its accurate human-motion i...

ECG theoretical knowledge and interpretation competency of arrhythmias in final-year students: a cross-sectional study

Electrocardiography (ECG) is the key method for diagnosing arrhythmias. Nurses' prompt recognition and early clinical decisions can greatly improve patient outcomes, making it essential to develop nursing students' ECG interpretation skills for arrhythmias. This study aims to ass...

Admission versus historical serum creatinine alters AKI classification in cirrhosis: a retrospective study of MIMIC-IV and eICU-CRD

The serum creatinine (SCr) value used to define and stage acute kidney injury (AKI) can alter case identification and severity classification. The terminology used to identify kidney replacement therapy (KRT) also affects clinically important outcome counts. We quantified both ef...