Chengdu Medical College

A study on the screening of potential biomarkers for rheumatoid arthritis based on nontarget metabolomics

To explore changes in blood metabolites with rheumatoid arthritis (RA) using non-targeted metabolomics techniques, to identify potential metabolic biomarkers in RA patients. Twenty patients with rheumatoid arthritis (RA group) who attended the Sichuan Province Orthopaedic Hospita...

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

ABSTRACT The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed a...

Construction of In Vitro-In Vivo Correlation (IVIVC) Degradation Evaluation Model of Absorbable PCL/β-TCP Alveolar Bone Repair Scaffold and Exploration of a Biosafety Evaluation Idea Based on “Homeostasis”

Abstract Traditional in vivo degradation assessments for resorbable medical devices face challenges due to extreme durations, high costs, and a lack of criteria for reaching tissue-response steady states. This study investigates a 3D-printed PCL/β-TCP bone grafting scaffold by de...

Recent Advances in Comprehending Endothelial Dysfunction and Diabetic Cardiomyopathy: From Molecular Mechanisms to Clinical Applications

Diabetic cardiomyopathy (DCM) is a cardiac condition characterized by various structural and functional abnormalities that are associated with diabetes mellitus. Its development involves multiple factors, among which endothelial dysfunction plays a significant role. To fully desc...

Impact of IL-6 receptor inhibitors on cerebrospinal fluid metabolites in type 2 diabetes patients

This study aimed to investigate whether interleukin-6 (IL-6) receptor inhibitors affect cerebrospinal fluid (CSF) metabolites in type 2 diabetes (T2D) patients. The initial phase employed drug-targeted Mendelian randomization to investigate the association between IL-6 receptor i...

Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma

Abstract Clear cell renal cell carcinoma (ccRCC) exhibits a paradoxical fructose metabolism signature characterized by upregulation of the fructose transporter GLUT5 alongside downregulation of the catabolic enzymes (ketohexokinase, aldolase B, and triokinase), a pattern associat...

Quantitative Evaluation of Cervical Spine Morphometry: Zero Echo Time MRI Versus Multislice CT

BACKGROUND: For preoperative cervical assessment, both CT and MRI are often required for bony and soft-tissue evaluation, yet CT entails radiation and MRI poorly depicts cortical bone. ZTE offers CT-like contrast in one examination, but whether it correlates with CT for quantitat...

Engineered desialylated platelet membrane camouflaged liposomes for the regulation of kupffer cells and hepatic stellate cells in treatment of liver fibrosis

The intercellular crosstalk and reciprocal activation between Kupffer cells (KCs) and hepatic stellate cells (HSCs) are critical drivers of liver fibrosis progression. Nonetheless, the co-regulation of KCs and HSCs is hindered by their distinct anatomical locations and the pathol...

Causal association between air pollution and functional outcome after ischemic stroke: Evidence from 2-sample MR study

Observational studies have shown that air pollution may affect functional outcome following ischemic stroke. Our study aimed to explore the relationship between genetically predicted specific air pollutants and poststroke functional outcomes using the Mendelian randomization (MR)...

Research on the dynamic evolution of competitive and water-film-mediated wear mechanisms of the carbon strips in the pantograph-catenary system at low temperature

Abstract To investigate the evolution of wear mechanisms in carbon strips at low temperature, this study conducted comparative friction tests on copper-impregnated carbon strips at room temperature (25 °C) and low temperature (-20 °C). To replicate operating conditions, the exper...

Mechanisms of ferroptosis in Echinococcus granulosus cyst fluid-induced hepatic injury and the protective role of Nrf2 activation

Cystic echinococcosis (CE) is a globally distributed parasitic zoonosis caused by infection with Echinococcus granulosus. This study investigated the ferroptosis mechanism in hepatocyte injury induced by Echinococcus granulosus cyst fluid (EgCF) and its relationship with the nucl...

Longitudinal dynamics of the maternal gut virome associate with metabolic features of preterm birth

Preterm birth (PTB) remains a major pregnancy complication, yet the role of the maternal gut virome in its etiology is largely unknown. Here we show that the maternal gut virome undergoes ecological destabilization prior to PTB, coupled with distinct host metabolic remodeling. Ne...