Charité - Universitätsmedizin Berlin

Diving deep into uterine layers: ADC and IVIM at 0.55-T MRI

Abstract Objective To investigate and analyze the microstructure of uterine layers and to evaluate the feasibility and physiological variability of uterine diffusion metrics at 0.55-T MRI in healthy volunteers and participants with adenomyosis. Materials and methods In this prosp...

Early Multicentre Outcomes of Endovascular Aortic Arch Repair Using a Custom-Made Triple-Branch NEXUS TRE Endograft System (TRE-ASURE Study)

Objective: To report the first multicentre European experience with the custom-made NEXUS TRE triple-branch endograft for fully endovascular, debranch-free repair of complex aortic arch pathology, focusing on technical feasibility and early safety outcomes. Methods: This retrospe...

Belantamab mafodotin plus venetoclax in t(11;14)-positive relapsed or refractory multiple myeloma – the BELI(E)VE trial

Abstract Background Multiple myeloma (MM) is a widely incurable B-cell malignancy that predominantly affects older adults, representing 10% of hematologic cancers. Despite advancements in therapy that have significantly extended median overall survival (OS), MM remains a clinical...

Level-dependent changes in cervical multifidus composition following anterior cervical discectomy and fusion: bridging quantitative MRI and clinical perspectives

Fatty infiltration (FI) of the cervical paraspinal muscles is associated with greater disease severity and less favorable outcomes in degenerative cervical spine disease. However, longitudinal data on whether muscle composition changes following anterior cervical discectomy and f...

The efficacy and safety of celecoxib for postoperative pain in major orthopedic surgery: a systematic review and pairwise meta-analysis

Effective postoperative pain management is crucial for surgical recovery, yet opioid-based therapies carry significant risks of addiction and adverse effects. Celecoxib, a selective COX-2 inhibitor, has emerged as a promising non-opioid alternative within multimodal analgesic pro...

Anatomical Determinants of the Left Atrial Electrograms: Wall Thickness and Myocardial Fat Infiltration

INTRODUCTION: Electrogram peak-to-peak voltage depends on atrial wall structure and mapping configuration. We evaluated the relationship between computed tomography-derived atrial wall thickness, intramyocardial fat, myocardial muscle thickness, and electrogram voltage obtained w...

Outcomes in JIA have greatly improved, but we can still do better

Abstract Outcomes for children and adolescents with juvenile idiopathic arthritis (JIA) have improved substantially over the past two decades, driven by biologic and targeted synthetic DMARDs, treat-to-target strategies with regular standardized assessments, and multidisciplinary...

Comparative Pharmacokinetics of Trientine Dihydrochloride Capsules: A Randomized, Open-Label, Reference-Controlled, Two-Period Crossover Study in Healthy Volunteers

Trientine dihydrochloride (TETA-2HCl) is an oral copper chelator used for Wilson disease. Because available formulations differ in marketed strength and may have formulation-specific pharmacokinetic properties, this study compared a 250 mg test capsule and a 300 mg reference caps...

Anodal Transcranial Direct Current Stimulation Improves Social Behavior Alongside Neuroplastic Changes in a Tsc2 +/− Rat Model of Autism Spectrum Disorder

ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by altered synaptic connectivity and network organization, resulting in profound impairments in social communication and interaction. Transcranial direct current stimulation (tDCS) represents a...

Whole-body quantitative muscle MRI in myotonic dystrophy type 2: a sensitive tool for pattern recognition, disease stratification and objective assessment of clinical severity

Background Myotonic dystrophy type 2 (DM2) is a frequent yet underdiagnosed muscle disorder. Although muscle MRI is increasingly used in neuromuscular disorders, there is an overt lack of evidence regarding its role in DM2. This study aimed to characterise whole-body muscle invol...

Ecological momentary insights into cannabis use and its contexts: a pre-post legalization study in Germany

Abstract Globally, cannabis ranks third in psychoactive substance prevalence after nicotine and alcohol, with heavy use linked to psychosis, anxiety, and depression. However, real-time data on how legal reforms influence consumption remain scarce. This Ecological Momentary Assess...

Imputing longitudinal PROM data at the item and score level in clinical trials

Abstract Background Missing data in patient-reported outcome measures (PROMs) can affect estimation accuracy and inferential validity, particularly under missing-at-random (MAR) mechanisms. Multiple imputation (MI) is commonly recommended, but the relative performance of item-lev...

Hippocampal volume changes in astronauts and bilateral vestibulopathy patients

Abstract The hippocampus is a particularly plastic and vulnerable brain structure. Given the modulatory role of the vestibular system on hippocampal function, we hypothesized that altered vestibular stimulation associated with prolonged spaceflight could lead to similar hippocamp...

Signals of Communicative Intent Enhance the Impact of Emotional Messages from Human Speakers, While Effects for Robots are Attenuated

Abstract The present work investigated humans’ responses to robots’ verbal emotional expressions. To this end, the interplay of agent characteristics and signals of communicative intent on emotional word processing was examined. In two behavioral studies (N1 = 36, N2 = 72), parti...

Anticipating the hospital of the future: stakeholder perspectives on 6G technology requirements in health care

PURPOSE: The ongoing 6G standardization process is largely driven by technical advancements, but with limited consideration of sector-specific needs, particularly in health care. The current scientific literature primarily focuses on technical aspects, offering minimal empirical...

Associations of menstrual cycle length with GDM and gestational hypertension in frozen embryo transfer

Prolonged menstrual cycles may indicate potential cardiometabolic conditions; however, there are limited data on how these associations vary among women without polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF). In this study, we aimed to investigate the as...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Micronutrients in adult critically ill patients: lessons learned and the path toward precision

Purpose of review Despite strong biological plausibility, empiric high-dose micronutrient supplementation has failed to improve outcomes in critically ill patients. This review synthesizes evidence from the past 18 months and outlines the necessary transition toward biomarker-gui...

Ischemic strokes as an initial manifestation of eosinophilic granulomatosis with polyangiitis with eosinophilic myocarditis: a case report

Abstract Background Eosinophilic myocarditis (EM) is a rare form of myocarditis which may be caused by eosinophilic granulomatosis with polyangiitis (EGPA), a rare disease which frequently affects the heart. The case of a young woman with a rare initial manifestation of EGPA as a...

Integrative Muscle-Adipose Score (IMAS)

OBJECTIVE: To investigate the potential of integrating muscle and fat compartments into a novel and unified score for outcome prediction in a bicentric European cohort of LT recipients. BACKGROUND: Body composition (BC) reflects nutritional status and metabolic reserves and influ...