Charité - Universitätsmedizin Berlin

Development of a prediction model for occupational satisfaction among cancer patients following counseling in German psychosocial cancer counseling centers

Abstract A prognostic model was developed and internally validated to predict satisfaction with the occupational situation among cancer patients receiving psychosocial counseling regarding return to work (RTW). Data were collected from outpatient cancer counseling centers in Germ...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

A multimodal manual therapy, exercise, and psychological intervention for painful diabetic neuropathy: the NeuOst feasibility randomised controlled trial.

Introduction: People with painful diabetic neuropathy lack effective and tolerable treatments. Physical and psychological interventions may help but require further study and combination to maximise effects. Objectives: This single-site, 3-arm, parallel, randomised feasibility tr...

Tinnitus in urban settings: insights into lifestyle and medical factors from the Hamburg City Health Study

PURPOSE: Tinnitus is a common and multifactorial auditory condition associated with considerable psychosocial burden. Evidence regarding its relationship with demographic, lifestyle, and medical factors remains inconsistent. This study aimed to determine the prevalence and correl...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

Integrative structural modelling reveals the human Mic60-Mic19 subcomplex as a diffusion barrier in mitochondria

Abstract Mitochondrial crista junctions (CJs) operate as regulated gateways into the cristae microenvironment, whose protein, metabolite, and ion compositions are finely tuned for mitochondrial function. The Mic60-Mic19 complex of the mitochondrial contact site and cristae organi...

Rheumatologists’ expectations and perceptions of T-cell redirecting therapies: results from a cross-sectional survey

Abstract T-cell redirecting therapies (TCRTs), including Chimeric antigen receptor (CAR)-T cells and T-cell engagers (TCEs), are emerging as transformative treatments for autoimmune diseases. However, clinical application is currently restricted to specialized centers, leaving mo...

From Diagnosis to Long-Term Survivorship: A Scoping Review of Specialist or Advanced Nursing Roles in Gynecologic Oncology

OBJECTIVES: Due to rising survival rates in gynecologic cancers, the need for holistic, patient-centered, and multidisciplinary survivorship care is increasing. Evolving specialist or advanced nursing roles can help to improve quality of life within the interprofessional care tea...

Complete Reporting for Transparent Reproducibility Efforts (CORTRE)

The CORTRE project develops a consensus-based reporting guideline for reproduciblity efforts -- projects that systematically re-examine previously published findings to investigate an aspect of their reproducibility. The project was launched at the Responsible Research in Action...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Prophylactic vs Therapeutic Anticoagulation in Hospitalized Patients With COVID-19

Importance Coagulopathy in the context of COVID-19 is a major threat due to deep vein thromboses and pulmonary embolisms. Objective To assess whether therapeutic anticoagulation on top of standard of care (SOC) compared with prophylactic anticoagulation as part of SOC can improve...

Artificial intelligence in radiographic quantification and severity assessment of peri‐implant marginal bone loss: A systematic review

ABSTRACT Purpose To critically assess artificial intelligence (AI)‐based radiographic models for quantitative measurement, localization/detection, segmentation/keypoints, diagnostic classification, and severity or morphology assessment of peri‐implant marginal bone loss (MBL) and...

Older patients and intensive care: factors that influence patients decisions on life sustaining measures

Abstract Background Physicians treating older patients are frequently unaware of their patients’ personal attitudes towards life-sustaining measures like ventilation, resuscitation, feeding tubes, or ICU admission. In routine clinical practice, there is often little time for refl...

RCC-AID: Renal Cell Carcinoma AI Dataset for Medical Imaging Research

Contrast-enhanced computed tomography (CT) is central to the diagnosis, staging, and follow-up of patients with renal cell carcinoma (RCC). As artificial intelligence research into computer-aided solutions continues to grow, the need for curated and annotated datasets becomes inc...

Long‐Term Clinical Outcomes of Arthroscopic Suture Anchor Fixation of Bony Bankart Lesions at a Mean 18‐Year Follow‐Up

PURPOSE: To evaluate shoulder stability and function at long-term follow-up after arthroscopic single-row suture anchor fixation of bony Bankart lesions. METHODS: This was a retrospective, single-center study. Patients with anterior glenoid rim fractures after traumatic shoulder...

Early kidney injury occurs in the absence of detectable perirenal adipose tissue remodelling in the Munich Wistar Frömter rat model of chronic kidney disease

Adipose tissue surrounding the kidney, known as perirenal adipose tissue (PRAT), is a metabolically active depot that may influence renal function through inflammatory and fibrotic mediators. In the Munich Wistar Frömter (MWF) rat, a genetic model of spontaneous chronic kidney di...

Outcome‐Guided Immunosuppressive Therapy and Clinical Events in Patients With Cardiac Sarcoidosis: An Observational Registry

Background Immunosuppressive therapy (IST) is commonly used in cardiac sarcoidosis, but the strategy to guide it is unclear and its effectiveness uncertain. We assessed the association between IST, guided by clinical course and positron emission tomography, and clinical outcomes...

SARS-CoV-2 and RSV external quality assessment on molecular detection and variant typing in European expert laboratories in 2025

ABSTRACT We herein report on the fourth SARS-CoV-2 wet-lab external quality assessment (EQA) and the second organized by the AURORAE consortium to assess the diagnostic capabilities of European expert public health laboratories. Diagnostic capabilities were investigated regarding...

Diving deep into uterine layers: ADC and IVIM at 0.55-T MRI

Abstract Objective To investigate and analyze the microstructure of uterine layers and to evaluate the feasibility and physiological variability of uterine diffusion metrics at 0.55-T MRI in healthy volunteers and participants with adenomyosis. Materials and methods In this prosp...

Migration and tuberculosis transmission in Hamburg, Germany: insights from 25 years of molecular epidemiology

Abstract Background Tuberculosis (TB) epidemiology in low-incidence settings is increasingly influenced by the importation of Mycobacterium tuberculosis complex (Mtbc) strains from high-incidence regions. Globally, more virulent “generalist” lineages such as Lineage 2 (L2) and Li...