Centers for Disease Control and Prevention

Memory B Cell Repertoire of a Repeatedly Vaccinated Individual Includes Influenza Hemagglutinin-Specific Cross-Group Binders with Affinity Beyond A(H1N1)pdm09 and A(H3N2) Seasonal Strains

Background/Objectives: Humans are primarily infected by two distinct seasonal influenza A virus (IAV) subtypes, A(H1N1)pdm09 and A(H3N2). Because IAV mutates rapidly, it continuously escapes existing protective antibodies. However, repeated exposure to these evolving strains incr...

Sociodemographic and Clinical Factors Associated With Nirsevimab Receipt Among Children Aged Younger Than 20 Months in the New Vaccine Surveillance Network in 2023 to 2025

OBJECTIVES: We aim to evaluate the association of sociodemographic and clinical factors with nirsevimab receipt among children with medically attended acute respiratory illness (ARI) across multiple seasons and beyond birth hospitalization. PATIENTS AND METHODS: We included nirse...

Atlas of gross, histologic, and immunohistologic anatomy of the lymphoid system in Egyptian rousettes (Rousettus aegyptiacus)

Abstract Chiropterans exhibit remarkable immunological adaptations that facilitate their function as competent reservoir hosts for diverse high-consequence zoonotic viruses while maintaining apparent clinical health. The Egyptian rousette ( Rousettus aegyptiacus ), a frugivorous...

Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses

The emergence of the SARS-CoV-2 Omicron BA.2.86 subvariant, a lineage derived from the BA.2 strain, led to the 2024-2025 COVID-19 vaccine update to include KP.2 or related JN.1-lineage spike antigens. We evaluated the magnitude, breadth, and durability of humoral immune responses...

Hepatitis B and hepatitis C awareness, knowledge, and practices among adults in the Kyrgyz Republic—results from a nationally representative survey, 2024

<title>Abstract</title> Background Hepatitis B and hepatitis C are primary drivers of cirrhosis, a leading cause of death in the Kyrgyz Republic (KR). Assessing hepatitis B and hepatitis C awareness, knowledge, and behavioral practices are important to guide prevention, testing,...

Addressing barriers to using fixed-dose combination antihypertensive medications: lessons from the Million Hearts initiative

In the United States, 119.9 M adults have hypertension, defined as blood pressure ≥130/80 mmHg [ 1 ]. Among this group, 67.9 M adults have uncontrolled high blood pressure and are recommended to be on antihypertensive medications according to clinical guidelines. Of those with un...

Commensal bacteria inhibit viral infections via a tryptophan metabolite

Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplored. Here, we define a pathway by which viral inf...