Cedars-Sinai Medical Center

Integrating ctDNA-Based ESR1 m Monitoring Into First-Line Care for ER+, HER2– Advanced Breast Cancer: A Consensus Workflow

Circulating tumor DNA (ctDNA) is an emerging tool in precision oncology that enables noninvasive tumor profiling, detection of minimal residual disease, and treatment monitoring. Furthermore, routine ctDNA analyses offer the potential to support more personalized and dynamic canc...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Associations of Mild or Trace Valvular Abnormalities With Cardiac Remodeling in Older Adults: The ARIC Study

Background The impact of mild/trace valvular abnormalities on cardiac remodeling is not well understood, despite their association with poor cardiovascular outcomes. Methods Using data from 4684 participants in the ARIC (Atherosclerosis Risk in Communities) Study (2011–2013), age...

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Affibody-based approaches as potential therapeutics for breast cancer: mechanisms, applications, and future perspectives

Breast cancer presents a significant therapeutic challenge due to the substantial molecular and genetic diversity among its subtypes, thereby necessitating the development of refined intervention strategies. Macromolecular therapies, such as monoclonal antibodies, are often hinde...

Optimizing longitudinal follow‐up after hypertensive disorders of pregnancy: A quality improvement initiative

Abstract Objective Hypertensive disorders of pregnancy (HDP) are associated with increased risk for future cardiovascular disease. Guidelines recommend longitudinal follow‐up for cardiovascular risk stratification after pregnancy complicated by HDP; however, adherence to this rec...

Early-life microbiota direct an epithelial S100 program required for neonatal immunity

Despite appreciation that neonatal immune responses differ markedly from those of adults, the mechanisms that enable early-life immunity remain poorly understood. Here, we find that healthy newborn mice express high concentrations of the S100 calcium-binding protein A8/A9 (S100A8...

Omics data discovery agents: Agent-supported retrieval, reanalysis, and synthesis of published omics data

The biomedical literature contains a vast collection of omics studies, yet most published data remain functionally inaccessible for computational reuse. When raw data are deposited in public repositories, essential information for reproducing reported results is dispersed across...

Mitochondria-targeted DZ-1-dihydroartemisinin conjugate induces Bax/Bak-independent apoptotic cell death in colorectal carcinoma cells

Artemisinin and its derivatives possess anti-malarial as well as anti-cancer properties against various malignancies. However, their clinical application as anti-cancer agents is limited by several factors, most notably a lack of tumor selectivity. To address this limitation, we...

Rapid Whole Genome Sequencing Enhances Pediatric Cancer Diagnosis

Abstract Whole-genome sequencing (WGS) has been shown to improve diagnosis beyond standard-of-care genetic tests and guide precision treatment for childhood cancer. While WGS is now offered for children with suspected cancer in England, clinical workflows typically return results...

HIV and Antiretroviral Therapy Influence Tumor Microenvironment Architecture, Subclonal Evolution, and Immune Evasion Strategies in Diffuse Large B-Cell Lymphoma

The tumor immune microenvironment (TIME) and tumor heterogeneity shape prognosis and therapeutic response in Diffuse Large B-cell Lymphoma (DLBCL), but HIV-associated (HIV+) DLBCL remains poorly understood. To characterize the TIME and tumor-intrinsic features of DLBCL across a s...

American Rhinologic Society Expert Practice Statement: Indications and Recommendations for Posterior Nasal Nerve Ablation

ABSTRACT The goal of this American Rhinologic Society expert practice statement (EPS) is to provide an evidence‐based evaluation of the current literature on posterior nasal nerve ablation. Subtopics reviewed include the evidence for specific indications such as nonallergic rhini...

Non‐Rigid Motion‐Compensated MR Multitasking for Free‐Breathing Low‐Dose Dynamic Contrast‐Enhanced MRI in the Abdomen

ABSTRACT Purpose To improve free‐breathing low‐dose quantitative dynamic contrast‐enhanced (DCE) MRI for imaging pancreatic ductal adenocarcinoma. Methods We introduced non‐rigid (NR) motion compensation (MoCo) into MR Multitasking using a novel “in‐subspace” formulation that dir...

Effects of End-ischemic Hypothermic Oxygenated Perfusion on 1-y Graft Function in Kidney Transplantation: A Real-world, Single-center Analysis From the United States.

Background: Hypothermic oxygenated perfusion (HOPE) supplies oxygen to kidney allografts for resuscitation before transplantation and may improve graft recovery. This study represents the first U.S.-based comparative analysis evaluating the impact of HOPE on kidney transplant (KT...

Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus

Abstract Background Mechanical ventilation is associated with acute and long-term cognitive dysfunction, yet the molecular pathways linking ventilator-induced lung injury (VILI) to brain injury remain poorly characterized. We previously demonstrated that peripheral IL-6 signaling...

Challenges in establishing epidemiological cut-off values for the Burkholderia cepacia complex

ABSTRACT The Burkholderia cepacia complex (BCC) is comprised of 24 species of gram-negative bacteria that cause opportunistic infections. While antimicrobial susceptibility testing (AST) has historically been used to guide treatment for BCC infections, recent work highlighting pr...

Expanding the Donor Pool: Successful Single Lung Transplant of a Hepatitis C Seropositive Donor to a Recipient With HIV and Pulmonary Fibrosis

Melissa Lesko, DO is on the advisory board for patientMpower, Ltd. (10/13 Thomas St. Dublin, Ireland). Bonnie Lonze, MD PhD has received research funding from AbbVie, Inc for work unrelated to this manuscript. The other authors declare no conflicts of interest.

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

OBJECTIVES: To elucidate role of beta-transducin repeat-containing protein 2 (β-TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. METHODS: ) mice. Bone microarchitecture was assessed by micro-computed tomography, and osteoclast and osteoblast...

Approved Medications for Substance Use Disorders: An Umbrella Review of Systematic Reviews and Completed Phase 3 Randomized Controlled Trials

This umbrella review of systematic reviews, meta-analyses, and completed phase 3 randomized controlled trials (RCTs) over the past 10 years covers approved pharmacological treatments for substance use disorders (SUD) worldwide, providing clinicians and researchers with a detailed...