Carol Davila University of Medicine and Pharmacy

Rescue Transcatheter Aortic Valve Implantation for Severe Native Aortic Regurgitation in a Young Patient with Hypertrophic Obstructive Cardiomyopathy and Cardiogenic Shock: Review of the Literature and Case Presentation

Transcatheter aortic valve implantation (TAVI) for pure native aortic regurgitation (AR) remains technically challenging, primarily because absent annular calcification limits prosthesis anchoring. We reviewed contemporary evidence on TAVI for native AR, focusing on devices, proc...

Modulation of Caffeine-Induced Behavioral Alterations by N-Acetylcysteine in a Pharmacological Challenge Model

Background: Caffeine is a widely consumed psychostimulant that may affect anxiety-like, aggression-like, and social behaviors, potentially in association with oxidative imbalance. Objectives: This study evaluated the behavioral and biochemical effects of acute caffeine exposure i...

Minimally Invasive Fassier–Duval Telescopic Rodding of the Lower Limb in Pediatric Osteogenesis Imperfecta: Current Evidence and Implications for Type I (Non-Deforming) Disease

Osteogenesis imperfecta (OI) is the most common heritable bone-fragility disorder, with type I (non-deforming OI) representing its mildest classical phenotype (historically referred to as Lobstein disease). Intramedullary (IM) rodding is essential for managing recurrent long-bone...

Revisiting gallbladder stones structure through integrated multiscale physicochemical characterization

Gallstones are complex biominerals formed through physicochemical, metabolic, and microbial processes. In this study, gallstones were comprehensively characterized, revealing a complex elemental profile comprising C, N, O, Mg, Al, Si, P, S, Ca, Cu, Mn, Fe, Co, Zn, and Cd. The cha...

Bioactive Multilayer Poly(ε-caprolactone)–Chitosan Coatings for Spinal Screws

Spinal surgery involves highly complex procedures where the risk of severe complications, including postoperative infections, may compromise both surgical success and patient survival. In this study, functional coatings for spinal screws were developed to promote bone integration...

Predictive Factors for Acute and Late Genitourinary and Gastrointestinal Toxicity Following Modern Radiotherapy for Prostate Cancer: A Narrative Review of Clinical, Dosimetric, Immunological, and Genetic Determinants

Background: Despite advances in prostate cancer (PC) radiotherapy, including intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiotherapy (SBRT), genitourinary (GU) and gastrointestinal (GI) toxicities remain important compl...

Improving nurses' compliance with evidence-based falls prevention practices in urology settings: a best practice implementation project.

INTRODUCTION: Falls represent multifactorial adverse events and are a major challenge in the care of patients with urological conditions. AIM: The aim of this evidence implementation project was to improve fall prevention practices in three urology wards of a specialized hospital...

Comparative Analysis of Phenolic Acid Profiles, Antioxidant Capacity, and Antimicrobial Activity of Honeys from Different Botanical and Geographical Origins

The composition of honey is complex and can vary depending on its botanical and geographical origin. This study evaluated the phenolic acid profile (PAP), antioxidant activity, and antimicrobial properties of honey samples from different geographical origins, such as Romania (nin...

Subjective Xerostomia and Chairside Salivary Dysfunction in Institutionalized Older Adults: Concordance and Exploratory Derivation of a Five-Item Short Form

Background/Objectives: In institutionalized older adults, we examined the concordance between self-reported xerostomia and chairside salivary dysfunction and explored whether a smaller subset of Xerostomia Inventory items could retain comparable screening performance. Methods: Th...

Apparent diffusion coefficient metrics for adult-type diffuse gliomas classified according to WHO 2021: a systematic review

Abstract Purpose This study aimed to determine the associations of apparent diffusion coefficient (ADC) values with the molecular and histological subtypes of adult-type diffuse gliomas classified in accordance with the 2021 World Health Organization (WHO) Classification of Tumor...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Physicians Retain Moral Responsibility but Endorse Institutional Co-Responsibility in AI-Assisted Decisions: An Exploratory Vignette Study

Background: Artificial intelligence (AI) systems, including large language models, are increasingly used in clinical practice, whether consulted informally by clinicians or introduced by employers into decision workflows. It remains unclear how physicians attribute moral responsi...

Challenges in deep learning-based small organ segmentation: A benchmarking perspective for medical research with limited datasets

Accurate segmentation of carotid artery structures in histopathological images is vital for cardiovascular disease research. This study systematically evaluates ten deep learning segmentation models including classical architectures, modern CNNs, a Vision Transformer, and foundat...

Smart Polymeric Wound Dressings for Wound Treatment: Contributions and Applications

Wound management continues to represent a major global healthcare challenge, with the wound care market growing each year and a rising incidence of chronic wounds worldwide. Effective wound healing requires dressings that protect injured tissue, prevent infection, and actively mo...

From Medical Records to AI-Ready Datasets: A Practical Guide for Clinical Researchers

Background: Medical artificial intelligence (AI), machine learning (ML), and deep learning (DL) studies frequently begin with datasets collected for routine care rather than for computational modeling. Such datasets may contain inconsistent variables, heterogeneous measurement ti...

Epidemiological Profile of High-Risk HPV in Cervical Samples for Liquid-Based Cytology: Insights from Screening and Symptomatic Cohorts

High-risk human papillomavirus (HR-HPV) infection is the principal etiological factor in cervical cancer, with genotype distribution and cytological associations varying across populations. This retrospective study aimed to characterize the prevalence and genotype distribution of...

Comparative Analysis by Machine Learning of Geriatric Frailty and Alzheimer’s Disease Classification Using Independent Datasets

Frailty syndrome and Alzheimer’s disease are prevalent conditions in the elderly that are associated with aging, decreased quality of life, and a significant healthcare burden. Evidence for a relationship between physical frailty and neurodegenerative decline is accumulating. Thi...

Nanotechnology in Pediatric Neurology: Applications and Innovations

Nanotechnology is rapidly transforming the perspective on pediatric neurology, enabling diagnostic, therapeutic, and monitoring strategies tailored to the unique features of neurological illnesses in children. This review acknowledges the problems caused by delays in diagnosis, t...

Rectal Surveillance for Carbapenem-Resistant Klebsiella pneumoniae: Prevalence and Clinical Relevance in a Multidisciplinary Tertiary-Care Hospital

Background/Objectives: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a high-priority healthcare-associated pathogen. This study aimed to estimate rectal CRKP carriage and characterize same-patient clinical-site CRKP detection. Methods: We conducted a single-center retrospe...

Association of Serum 25-Hydroxyvitamin D, Inflammatory, and Metabolic Biomarkers with Non-Proliferative Diabetic Retinopathy in Type 2 Diabetes Mellitus: A Cross-Sectional Study

Background: Non-proliferative diabetic retinopathy (NPDR) is a common microvascular complication of type 2 diabetes mellitus (T2DM) associated with chronic inflammation, metabolic dysregulation, and multiple interacting systemic factors. This study evaluated the associations of i...