Carol Davila University of Medicine and Pharmacy

Carbapenem-Resistant Klebsiella pneumoniae in Romania and South-Eastern Europe: A Multilingual Narrative Review of Pandemic-Era Trajectories, 2020–2025

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is the pathogen driving the deterioration of the European antimicrobial resistance landscape, and the burden falls disproportionately on Romania and South-Eastern Europe. The objective of this review was to synthesise evidence pub...

Systemic Sclerosis-Specific Determinants of Major Adverse Cardiovascular Events: Development of an Exploratory Cardiovascular Risk Model Beyond Traditional Risk Factors

Background: Patients with systemic sclerosis (SSc) have an increased burden of cardiovascular disease, resulting from the combined effects of traditional cardiovascular risk factors, chronic inflammation, endothelial dysfunction, and disease-specific vascular involvement. Current...

Selective immunoglobulin A deficiency and coeliac disease: Immune response dynamics

Abstract Objective To analyse the serological immune response in paediatric patients with selective immunoglobulin A deficiency (SIgAD) and coeliac disease (CeD), focusing on immunoglobulin G antibody dynamics after starting the gluten‐free diet (GFD). Methods Data from SIgAD pat...

Diagnostic Performance of Diffusion-Weighted MRI and ADC Values in Differentiating Atypical Leiomyomas from Uterine Sarcomas.

BACKGROUND: Leiomyomas are the most common benign uterine tumors, whereas uterine sarcomas are rare malignant neoplasms associated with high morbidity and mortality. Differentiation using imaging remains challenging because of overlapping radiologic features. PURPOSE: To evaluate...

The Influence of Ageing, Sex and Cause of Death on the Myocardial Tissue Collagen Fibrillary Component Behaviour.

AIM: The morphology and the function of human body are influenced by two main factors: the passing of the years and the increasing diversity of diseases with their subsequent lesions. The morphological structures of the heart are not exempt from the synergistic influence of these...

Interest in geriatric medicine training among health and social care professionals: the roles of experience and attitudes. Findings from the online survey of the COST Action PROGRAMMING 21122

Abstract Background The growth of ageing populations is increasing the requirement for professionals trained to care for older adults. Aims To explore factors associated with interest in further training in geriatrics across health and social care professionals. Methods The COST...

The anterior condylar confluence of Trolard and its venous tributaries: an anatomical review

Abstract The anterior condylar confluence (ACC) of Trolard is a small extracranial venous plexus at the external orifice of the hypoglossal canal. Described over 150 years ago and present in the classical French anatomical literature, it was largely absent from the Anglophone rad...

Longitudinal Stability of the Gut Microbiota in Relapsing–Remitting Multiple Sclerosis: A Prospective Observational Study

The gut microbiota plays a key role in immune regulation in multiple sclerosis (MS), yet longitudinal data on microbiome dynamics and their relationships with disability and biomarkers remain limited. This study aimed to identify longitudinal gut microbiome changes in patients wi...

Integrating Artificial Intelligence into Orthopedic Practice: Modeling Attitudes and Intentions to Use AI

Background/Objectives: Artificial intelligence is increasingly used in medicine, particularly in orthopedics, to support medical image interpretation, diagnosis, clinical decision-making, and treatment selection. Its integration into clinical practice depends largely on doctors’...

Adrenocortical Carcinoma: An Exceptional Survival Span Across a Tailored Management

Adrenocortical carcinoma (ACC) represents a very rare (an incidence of 1–2 cases per million) and aggressive malignancy (an overall 5-year survival of 15%). Less than 15–20% of cases involve a single metastatic disease. In this presentation, we documented a most exceptional survi...

Nonfatal Burden of Disease and Risk-Attributable Burden in Romania, 1990 to 2023: A Secondary Analysis of Global Burden of Disease 2023 Estimates

Background/Objectives: We assessed changes in nonfatal disease burden and risk attribution in Romania between 1990 and 2023. Methods: We analysed Global Burden of Disease (GBD) 2023 estimates of years lived with disability (YLDs), related nonfatal measures and risk attribution fo...

Clinical Characteristics, ERCP Management, and Early Adverse Events Among Patients with Choledocholithiasis at a Romanian Tertiary Referral Center: A Retrospective Cohort

Background: Choledocholithiasis is a common cause of biliary obstruction and may lead to acute cholangitis, pancreatitis, and other serious complications. Despite the widespread use of endoscopic retrograde cholangiopancreatography (ERCP), data describing the clinical profile and...

Recurrence of Benign Vocal Fold Lesions: Risk Factors and an Exploratory Comparison of Cold-Instrument and CO2 Laser Surgery in a Retrospective Cohort

Background and Objectives: Benign vocal fold lesions (BVFLs) are common causes of persistent dysphonia, but recurrence estimates are influenced by lesion type, outcome definition, and follow-up. We evaluated recurrence after documented lesion resolution and explored clinical fact...

Carbon Nano-Onion-Based Sensors for Relative Humidity, Gas, and Temperature Monitoring: A Review

In recent years, carbon nano-onions (CNOs), together with their functionalized derivatives, nanocomposites, and nanohybrids, have attracted increasing attention as sensing materials for monitoring relative humidity (RH), gases, and temperature. Their concentric graphitic structur...

Admission Liver Injury Is an Independent Predictor of Early and Overall Mortality in Hospitalized Patients with Moderate-to-Critical COVID-19: A Retrospective Cohort Study

Background: Liver injury (LI) is frequently observed in patients with COVID-19, particularly in severe forms of disease. However, its prognostic significance remains incompletely defined. Aim: To evaluate the association between LI at admission and clinical outcomes in hospitaliz...

Responsible Clinical AI in Dentistry: Trust, Professional Autonomy, and Perceptions of Accountability Across Stakeholders in Romania—A Multidisciplinary Cross-Sectional Survey

Background/Objectives: Artificial intelligence (AI) is entering clinical dentistry more quickly than the professional, ethical, and regulatory frameworks intended to govern it. Responsible implementation depends not only on diagnostic performance but on trust, professional autono...

Factors Associated with Severe Postoperative Complications (Clavien–Dindo Grades III–IV) After Left-Sided Colon Cancer Surgery: A Single-Centre Retrospective Cohort Study

Postoperative morbidity remains a significant challenge in the surgical treatment of colorectal cancer. Nevertheless, studies specifically evaluating short-term postoperative morbidity following left-sided colon cancer surgery are limited, and the factors associated with adverse...

Cardiovascular–Kidney–Metabolic Syndrome and Its Hepatic Dimension: A Narrative Review

Metabolic syndrome came to the attention of the scientific community several decades ago, and its definition has undergone multiple changes over time. It is currently defined by the coexistence of hypertension, central obesity, dyslipidemia, and impaired glucose metabolism, with...

Beyond H&E: CDX2 immunohistochemistry in tumor budding assessment of colorectal carcinoma.

BACKGROUND AND OBJECTIVES: Tumor budding (TB) phenomenon is recognized as one of the important adverse prognostic factors of colorectal carcinoma (CRC) and is currently assessed following to the International Tumor Budding Consensus Conference (ITBCC) recommendations on routine H...

Analysis of circulating bone-glucose profile and exerkine irisin across parathormone quartiles in patients with primary hyperparathyroidism.

BACKGROUND: Parathyroid tumors, mostly single or multiple adenomas, cause a hormonal imbalance via parathormone (PTH) excess, that further increases serum calcium (primary hyperparathyroidism) with both PTH- and calcium-related multi-organ consequences. Testing the bone turnover...