Carol Davila University of Medicine and Pharmacy

Physicians Retain Moral Responsibility but Endorse Institutional Co-Responsibility in AI-Assisted Decisions: An Exploratory Vignette Study

Background: Artificial intelligence (AI) systems, including large language models, are increasingly used in clinical practice, whether consulted informally by clinicians or introduced by employers into decision workflows. It remains unclear how physicians attribute moral responsi...

Challenges in deep learning-based small organ segmentation: A benchmarking perspective for medical research with limited datasets

Accurate segmentation of carotid artery structures in histopathological images is vital for cardiovascular disease research. This study systematically evaluates ten deep learning segmentation models including classical architectures, modern CNNs, a Vision Transformer, and foundat...

Smart Polymeric Wound Dressings for Wound Treatment: Contributions and Applications

Wound management continues to represent a major global healthcare challenge, with the wound care market growing each year and a rising incidence of chronic wounds worldwide. Effective wound healing requires dressings that protect injured tissue, prevent infection, and actively mo...

Epidemiological Profile of High-Risk HPV in Cervical Samples for Liquid-Based Cytology: Insights from Screening and Symptomatic Cohorts

High-risk human papillomavirus (HR-HPV) infection is the principal etiological factor in cervical cancer, with genotype distribution and cytological associations varying across populations. This retrospective study aimed to characterize the prevalence and genotype distribution of...

From Medical Records to AI-Ready Datasets: A Practical Guide for Clinical Researchers

Background: Medical artificial intelligence (AI), machine learning (ML), and deep learning (DL) studies frequently begin with datasets collected for routine care rather than for computational modeling. Such datasets may contain inconsistent variables, heterogeneous measurement ti...

Comparative Analysis by Machine Learning of Geriatric Frailty and Alzheimer’s Disease Classification Using Independent Datasets

Frailty syndrome and Alzheimer’s disease are prevalent conditions in the elderly that are associated with aging, decreased quality of life, and a significant healthcare burden. Evidence for a relationship between physical frailty and neurodegenerative decline is accumulating. Thi...

Nanotechnology in Pediatric Neurology: Applications and Innovations

Nanotechnology is rapidly transforming the perspective on pediatric neurology, enabling diagnostic, therapeutic, and monitoring strategies tailored to the unique features of neurological illnesses in children. This review acknowledges the problems caused by delays in diagnosis, t...

Rectal Surveillance for Carbapenem-Resistant Klebsiella pneumoniae: Prevalence and Clinical Relevance in a Multidisciplinary Tertiary-Care Hospital

Background/Objectives: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a high-priority healthcare-associated pathogen. This study aimed to estimate rectal CRKP carriage and characterize same-patient clinical-site CRKP detection. Methods: We conducted a single-center retrospe...

Association of Serum 25-Hydroxyvitamin D, Inflammatory, and Metabolic Biomarkers with Non-Proliferative Diabetic Retinopathy in Type 2 Diabetes Mellitus: A Cross-Sectional Study

Background: Non-proliferative diabetic retinopathy (NPDR) is a common microvascular complication of type 2 diabetes mellitus (T2DM) associated with chronic inflammation, metabolic dysregulation, and multiple interacting systemic factors. This study evaluated the associations of i...

Surgical Complexity and Postoperative Outcomes in Recurrent Versus Primary Incisional Hernias Following Elective Retromuscular Repair: A Retrospective Cohort Study

Background/Objectives: Recurrent incisional hernia remains a major challenge in abdominal wall surgery and is frequently associated with increased surgical complexity and adverse outcomes. However, its role as a distinct surgical entity and its cumulative operative impact remain...

Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence

BACKGROUND: Short-term studies have demonstrated that single-pill combinations (SPCs) improve adherence, reduce hypertension-related complications, and lower costs; however, long-term benefits remain unclear. This study compared adherence, healthcare resource utilization (HCRU),...

Nutritional Strategies for Recovery–Adaptation Coupling After Exercise: From Muscle Damage to Performance Remodeling

Background/Objectives: Recovery nutrition must restore near-term readiness without indiscriminately suppressing biological signals that contribute to repair and training adaptation. This review evaluates recovery–adaptation coupling (RAC) as a research framework and clarifies its...

Urinary Leakage During Sexual Activity: A Narrative Review of an Underdiagnosed Female Pelvic Floor Disorder

Coital urinary incontinence is a frequently underdiagnosed manifestation of female pelvic floor dysfunction, characterized by involuntary urine leakage during sexual activity, particularly during vaginal penetration or orgasm. Although interest in this condition has increased in...

Clinical Phenotypic Spectrum and Multisystem Burden in Neurofibromatosis Type 1: A Retrospective Regional Cohort Study

Background: Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder characterized by marked phenotypic heterogeneity. This study aimed to describe the clinical spectrum and multisystem burden of NF1 in a regional retrospective cohort. Methods: We retrospectively analyzed...

Aberrant ICA in the middle ear

An aberrant internal carotid artery (a-ICA) in the middle ear is rare, but it may be injured during routine otological procedures. This review examines 48 publications on its embryological basis, clinical presentation, imaging diagnosis, and management. The a-ICA results from age...

Cardiovascular Complications Associated with Uro-Oncology Treatments—A Primer for the Clinician

Cardiovascular complications increasingly challenge survivors of urological cancers, given the cardiotoxicity of therapies such as androgen deprivation, vascular endothelial growth factor receptor inhibitors, tyrosine kinase inhibitors, immune checkpoint inhibitors, and chemother...

Ureaplasma Species in Perinatal Disease: From the Age of Innocence to the Missing Villain

Ureaplasma urealyticum and Ureaplasma parvum occupy an odd place in perinatal medicine: dismissed for decades as harmless residents of the female genital tract, they are now recognized as pathogens with real consequences for preterm newborns. This review traces that paradigm shif...