Carol Davila University of Medicine and Pharmacy

Clinical Characteristics, ERCP Management, and Early Adverse Events Among Patients with Choledocholithiasis at a Romanian Tertiary Referral Center: A Retrospective Cohort

Background: Choledocholithiasis is a common cause of biliary obstruction and may lead to acute cholangitis, pancreatitis, and other serious complications. Despite the widespread use of endoscopic retrograde cholangiopancreatography (ERCP), data describing the clinical profile and...

Recurrence of Benign Vocal Fold Lesions: Risk Factors and an Exploratory Comparison of Cold-Instrument and CO2 Laser Surgery in a Retrospective Cohort

Background and Objectives: Benign vocal fold lesions (BVFLs) are common causes of persistent dysphonia, but recurrence estimates are influenced by lesion type, outcome definition, and follow-up. We evaluated recurrence after documented lesion resolution and explored clinical fact...

Nonfatal Burden of Disease and Risk-Attributable Burden in Romania, 1990 to 2023: A Secondary Analysis of Global Burden of Disease 2023 Estimates

Background/Objectives: We assessed changes in nonfatal disease burden and risk attribution in Romania between 1990 and 2023. Methods: We analysed Global Burden of Disease (GBD) 2023 estimates of years lived with disability (YLDs), related nonfatal measures and risk attribution fo...

Carbon Nano-Onion-Based Sensors for Relative Humidity, Gas, and Temperature Monitoring: A Review

In recent years, carbon nano-onions (CNOs), together with their functionalized derivatives, nanocomposites, and nanohybrids, have attracted increasing attention as sensing materials for monitoring relative humidity (RH), gases, and temperature. Their concentric graphitic structur...

Admission Liver Injury Is an Independent Predictor of Early and Overall Mortality in Hospitalized Patients with Moderate-to-Critical COVID-19: A Retrospective Cohort Study

Background: Liver injury (LI) is frequently observed in patients with COVID-19, particularly in severe forms of disease. However, its prognostic significance remains incompletely defined. Aim: To evaluate the association between LI at admission and clinical outcomes in hospitaliz...

Responsible Clinical AI in Dentistry: Trust, Professional Autonomy, and Perceptions of Accountability Across Stakeholders in Romania—A Multidisciplinary Cross-Sectional Survey

Background/Objectives: Artificial intelligence (AI) is entering clinical dentistry more quickly than the professional, ethical, and regulatory frameworks intended to govern it. Responsible implementation depends not only on diagnostic performance but on trust, professional autono...

Factors Associated with Severe Postoperative Complications (Clavien–Dindo Grades III–IV) After Left-Sided Colon Cancer Surgery: A Single-Centre Retrospective Cohort Study

Postoperative morbidity remains a significant challenge in the surgical treatment of colorectal cancer. Nevertheless, studies specifically evaluating short-term postoperative morbidity following left-sided colon cancer surgery are limited, and the factors associated with adverse...

Cardiovascular–Kidney–Metabolic Syndrome and Its Hepatic Dimension: A Narrative Review

Metabolic syndrome came to the attention of the scientific community several decades ago, and its definition has undergone multiple changes over time. It is currently defined by the coexistence of hypertension, central obesity, dyslipidemia, and impaired glucose metabolism, with...

Analysis of circulating bone-glucose profile and exerkine irisin across parathormone quartiles in patients with primary hyperparathyroidism.

BACKGROUND: Parathyroid tumors, mostly single or multiple adenomas, cause a hormonal imbalance via parathormone (PTH) excess, that further increases serum calcium (primary hyperparathyroidism) with both PTH- and calcium-related multi-organ consequences. Testing the bone turnover...

Beyond H&E: CDX2 immunohistochemistry in tumor budding assessment of colorectal carcinoma.

BACKGROUND AND OBJECTIVES: Tumor budding (TB) phenomenon is recognized as one of the important adverse prognostic factors of colorectal carcinoma (CRC) and is currently assessed following to the International Tumor Budding Consensus Conference (ITBCC) recommendations on routine H...

Rescue Transcatheter Aortic Valve Implantation for Severe Native Aortic Regurgitation in a Young Patient with Hypertrophic Obstructive Cardiomyopathy and Cardiogenic Shock: Review of the Literature and Case Presentation

Transcatheter aortic valve implantation (TAVI) for pure native aortic regurgitation (AR) remains technically challenging, primarily because absent annular calcification limits prosthesis anchoring. We reviewed contemporary evidence on TAVI for native AR, focusing on devices, proc...

Minimally Invasive Fassier–Duval Telescopic Rodding of the Lower Limb in Pediatric Osteogenesis Imperfecta: Current Evidence and Implications for Type I (Non-Deforming) Disease

Osteogenesis imperfecta (OI) is the most common heritable bone-fragility disorder, with type I (non-deforming OI) representing its mildest classical phenotype (historically referred to as Lobstein disease). Intramedullary (IM) rodding is essential for managing recurrent long-bone...

Modulation of Caffeine-Induced Behavioral Alterations by N-Acetylcysteine in a Pharmacological Challenge Model

Background: Caffeine is a widely consumed psychostimulant that may affect anxiety-like, aggression-like, and social behaviors, potentially in association with oxidative imbalance. Objectives: This study evaluated the behavioral and biochemical effects of acute caffeine exposure i...

Revisiting gallbladder stones structure through integrated multiscale physicochemical characterization

Gallstones are complex biominerals formed through physicochemical, metabolic, and microbial processes. In this study, gallstones were comprehensively characterized, revealing a complex elemental profile comprising C, N, O, Mg, Al, Si, P, S, Ca, Cu, Mn, Fe, Co, Zn, and Cd. The cha...

Predictive Factors for Acute and Late Genitourinary and Gastrointestinal Toxicity Following Modern Radiotherapy for Prostate Cancer: A Narrative Review of Clinical, Dosimetric, Immunological, and Genetic Determinants

Background: Despite advances in prostate cancer (PC) radiotherapy, including intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiotherapy (SBRT), genitourinary (GU) and gastrointestinal (GI) toxicities remain important compl...

Bioactive Multilayer Poly(ε-caprolactone)–Chitosan Coatings for Spinal Screws

Spinal surgery involves highly complex procedures where the risk of severe complications, including postoperative infections, may compromise both surgical success and patient survival. In this study, functional coatings for spinal screws were developed to promote bone integration...

Improving nurses' compliance with evidence-based falls prevention practices in urology settings: a best practice implementation project.

INTRODUCTION: Falls represent multifactorial adverse events and are a major challenge in the care of patients with urological conditions. AIM: The aim of this evidence implementation project was to improve fall prevention practices in three urology wards of a specialized hospital...

Subjective Xerostomia and Chairside Salivary Dysfunction in Institutionalized Older Adults: Concordance and Exploratory Derivation of a Five-Item Short Form

Background/Objectives: In institutionalized older adults, we examined the concordance between self-reported xerostomia and chairside salivary dysfunction and explored whether a smaller subset of Xerostomia Inventory items could retain comparable screening performance. Methods: Th...

Comparative Analysis of Phenolic Acid Profiles, Antioxidant Capacity, and Antimicrobial Activity of Honeys from Different Botanical and Geographical Origins

The composition of honey is complex and can vary depending on its botanical and geographical origin. This study evaluated the phenolic acid profile (PAP), antioxidant activity, and antimicrobial properties of honey samples from different geographical origins, such as Romania (nin...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...