British Heart Foundation

Cardiovascular effects of chemoradiotherapy in patients with lung cancer: an [18F]FDG PET-CT imaging study

Abstract Background Cardiovascular and pro-atherogenic side-effects of chemoradiotherapy for non-small cell lung cancer (NSCLC) remain a major concern given the growing burden of cancer therapy-related cardiovascular disease. Atherosclerotic plaque burden can be measured using ca...

FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis

Genome-wide association studies have uncovered many coronary artery disease (CAD) loci, but mechanisms linking risk variants to vascular biology remain unclear. We screen candidate causal CAD genes for regulators of the vascular smooth muscle cell (VSMC) contractile phenotype usi...

Translational evidence for the antihypertensive potential of Passiflora edulis: a systematic review of preclinical and clinical studies

Abstract Introduction Passiflora edulis (PE) (passion fruit) is traditionally valued for its cardiovascular and calming properties, but its antihypertensive and blood pressure (BP)-lowering potential has not been systematically evaluated. Emerging evidence from preclinical and cl...

Comprehensive benchmarking of machine learning methods for risk prediction modelling from large-scale survival data: a UK Biobank study

Predictive modelling is vital to guide the prevention of incident disease (e.g., risk-based initiation of preventive pharmacotherapies). Whilst large-scale prospective cohort studies and a diverse toolkit of available machine learning (ML) algorithms have facilitated such surviva...