Boston Children's Museum

Transcriptome-based synthetic lethality predictions to improve targeted therapy/immunotherapy treatment prioritization in non-metastatic breast cancer: BC-SELECT

Abstract Patients with non-metastatic triple-negative (TNBC) or HER2-positive (HER2+) breast cancer do not have tools to predict treatment response or prioritize options prior to starting therapy. Pathologic complete response (pCR) is a proxy that requires neoadjuvant treatment....

A Real-World Evaluation of Large Language Model–Generated Hospital Courses in Pediatrics

BACKGROUND: Large language model (LLM)-generated hospital courses are increasingly integrated into electronic health records (EHRs), yet their accuracy and safety in pediatric populations remain poorly characterized. OBJECTIVE: To evaluate the accuracy, text quality, and perceive...

Program Directors’ Varied Conceptions of Practice Readiness

BACKGROUND: Residency graduates must be "practice ready" by the time they leave training. This study explored how pediatric residency program directors view their role and responsibility in determining practice readiness and examined how characterizations of practice readiness di...

Severe Fetal Cardiomyopathy: Considerations for Extracorporeal Cardiopulmonary Resuscitation During Neonatal Resuscitation

Primary cardiomyopathies are associated with poor neonatal outcomes, including high mortality rates. Neonatal care of infants with significant prenatal cardiac diagnoses may warrant additional management considerations beyond standard Neonatal Resuscitation Program guidelines. Ma...

Nanobodies specific for Vβ11 enable detection and noninvasive imaging of antigen-specific T cells in vivo

Through screening of a VHH phage display library constructed from an alpaca immunized with the recombinantly expressed murine myelin oligodendrocyte (MOG)-specific 2D2 T cell receptor (TCR), we identified nanobodies that reduced antigen-driven 2D2 T cell activation in vitro. Immu...

Fatal Neuroinvasive Astrovirus VA1 Encephalitis in a Child With High‐Risk B‐ALL Receiving Blinatumomab

O.L. is a named inventor on patents held by Boston Children's Hospital related to vaccine adjuvants and antigens as well as human in vitro systems that model the safety and immunogenicity of vaccines and immunotherapeutics. O.L.’s laboratory receives sponsored research support fr...

Developing Consensus Using the Delphi Method

The Delphi method is a technique for obtaining consensus from a panel of experts on a particular topic or set of decisions, such as diagnostic or treatment algorithms, medical education competencies, or curricular components. This article aims to introduce researchers new to cons...

Children With Complex Chronic Conditions in the Child Protective Services

OBJECTIVES: Little is known about the prevalence and outcomes for children with complex chronic conditions (CCCs) in the Child Protective Services (CPS) system. We aimed to determine the prevalence and associations of CCC designation across CPS outcomes and years among a group of...

Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance

The gut microbiome has been implicated in the pathogenesis of food allergy (FA), prompting microbiome-focused interventions. We evaluated, in a phase 1 open-label trial (NCT02960074), the safety and efficacy of oral encapsulated fecal microbiome transplantation (FMT) in 15 adults...