Boston Children's Museum

Characterizing In-Home Safety Challenges and Strategies for Children With Medical Complexity

OBJECTIVES: Medical advances have allowed more children with medical complexity (CMC) to live at home, but previous research has linked implanted tubes to patient safety events. We aimed to characterize challenges and strategies parents use to deliver their children's tube-relate...

Interim Update on Reactive Infectious Mucocutaneous Eruption ( RIME )

ABSTRACT Reactive infectious mucocutaneous eruption (RIME), a term describing blistering skin and mucosal lesions, is a term coined by a group of Pediatric Dermatology Research Alliance (PeDRA) researchers and first published in 2021. Since that time, the literature has grown wit...

Prediction of cardiovascular outcomes using electrocardiography from overnight polysomnography.

STUDY OBJECTIVES: Polysomnography (PSG) is the gold standard for diagnosing sleep disorders, which are recognized as cardiovascular risk factors. Single-lead electrocardiograms (ECGs) are recorded during PSG but rarely analyzed, presenting an opportunity to leverage overnight ECG...

Therapeutic Horseback Riding for Youth With Autism and Psychiatric Comorbidities: A Randomized Trial

OBJECTIVE: Autism spectrum disorder care is often complicated by co-occurring psychiatric symptoms. Equine-assisted services show promise for improving behavioral outcomes in this population. We aimed to examine benefits of equine-assisted services for youth with autism at higher...

The Multidimensional Nature of Pediatric Patient Complexity

OBJECTIVE: Patient complexity is defined in a variety of ways and is associated with health care costs and use. In this study, we evaluate whether pediatric inpatient complexity represents a single construct or multiple domains using multiple measures of diagnostic burden, health...

Sexually transmitted infection testing among U.S. adolescents in relation to U.S. Preventive Services Task Force screening guidelines

BACKGROUND: This study examined whether sexually transmitted infection (STI) testing patterns aligned with U.S. Prevention Services Task Force (USPSTF) screening recommendations among a large sample of U.S. adolescents. METHODS: Data were from Inclusive Care and Access to Resourc...

Inhibition of PLK1 helps to restrict c-Met-induced growth and therapeutic resistance of renal cancer cells

Acquired therapeutic resistance is a major problem in the treatment of advanced renal cell carcinoma (RCC). The receptor tyrosine kinase (RTK) c-Met is hyperactive in RCC and plays a major role in the survival of tumor cells during therapy-induced oxidative stress. Although c-Met...

Age-Associated Cognitive Deviations in Early-Onset Psychosis Patients and Their Siblings

OBJECTIVE: The objective of this study was to test for cognitive impairments and cross-sectional age-associated cognitive deviations in a large, diagnostically diverse, cross-sectional sample of children and adolescents with early-onset psychosis (EOP), their siblings, and nonpsy...

Developmental differences in platelet P-selectin expression modulate neonatal monocyte inflammatory responses

Neonatal and adult platelets are functionally different, with neonatal platelets being comparatively hypo-reactive to multiple platelet agonists. When transfused, neonates receive platelets from adult donors, resulting in a cellular developmental mismatch. Platelets are key regul...

Pediatric Hospital Medicine FTEs and Staffing Models

Appropriate physician staffing is essential to providing safe, high-quality care for hospitalized children. Many challenges exist in achieving optimal staffing, including financial constraints, coverage of off-hour shifts, recruitment shortages, and building models that promote s...

Promoting Optimal Pediatric Readiness at US Trauma Centers: Understanding and Addressing Barriers

Children treated at facilities prepared to provide emergency pediatric care have improved outcomes, but access to pediatric-ready care remains inconsistent. A multidisciplinary spotlight session at the 2026 American College of Surgeons Committee on Trauma Annual Meeting examined...

Time to diagnosis of acute kidney injury and its predictors among outborn neonates in India: a competing-risk analysis of tele-ICU network data (2022–2024)

Background There is limited data on neonatal acute kidney injury (AKI) from resource-constrained settings. In this study, we describe time to AKI diagnosis and its predictors among neonates born outside the treating hospital (outborn) in India, accounting for competing events lik...

Patterns of care for single ventricle infants in a home monitoring programme

Abstract Introduction: The advanced practice registered nurse-led home monitoring programme has served as an early warning system for the fragile population of single ventricle infants discharged home between their staged interventions. However, patterns of care by the home monit...

Longitudinal predictors of internalizing and externalizing behaviors in autism: Examining relationships with ritualistic behavior and social diagnostic features

Abstract Autistic youth commonly experience co-occurring mental health conditions. Core autism features have been linked to internalizing and externalizing symptoms, yet longitudinal pathways remain unclear. This study examined how ritualistic and social diagnostic features predi...

The Heart of the Matter — Transforming Congenital Heart Disease Care through Patient-Reported Outcomes

Patients with congenital heart disease (CHD) face substantial challenges in managing their chronic illness. Common and often unmet needs include neurocognitive challenges, mental health conditions, multiorgan disease, school and work impairment, and financial constraints. To impr...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Serum Chloride Trajectories and Acute Kidney Injury in Children With Diabetic Ketoacidosis

OBJECTIVES: To characterize serum chloride (Cl) burden during diabetic ketoacidosis (DKA), examine associations between Cl metrics and creatinine-defined acute kidney injury (CDAKI) and hospital length of stay (LOS), and to assess the relationship between initial beta-hydroxybuty...

Late Endocrine and Organ Toxicities After Treosulfan‐Based Conditioning in Pediatric Hematopoietic Cell Transplantation: A Systematic Review

Treosulfan is an alkylating agent indicated as a conditioning agent for allogeneic hematopoietic cell transplantation (HCT), with an established favorable acute toxicity profile; however, its long-term sequelae remain incompletely characterized. This review aims to characterize t...

A 6-Year-Old With Becker Muscular Dystrophy and Catatonia

Catatonia is often underrecognized and underdiagnosed, particularly in young children. Catatonia occurs secondary to a medical and/or psychiatric etiology. The diagnosis can be supported by validated rating scales, including the Pediatric Catatonia Rating Scale and/or response to...

Nuclear Localization Signals Enable the Cellular Delivery of an Anti-CRISPR Protein to Control Genome Editing

ABSTRACT Precise regulation of Cas9 activity is essential to minimize off-target effects, mosaicism, chromosomal alterations, immunogenicity, and genotoxicity in genome editing. Although type II anti-CRISPR proteins (Acrs) can inhibit and regulate Cas9, their size and anionic cha...