BioCruces Health research Institute

Defining fever-related discomfort in children: an international Delphi consensus

Fever is one of the most common symptoms in childhood and a frequent reason for medical consultation. Current guidelines recommend treating fever only when discomfort is present. However, the concept of fever-related discomfort remains poorly defined and inconsistently applied in...

Association of blood-pressure time-in-therapeutic range with morbidity and mortality in hypertensive patients: a retrospective cohort study in the community setting

Abstract Background Hypertension is one of the leading modifiable risk factors for cardiovascular disease. This study assessed the association between good blood pressure control (GBPC), measured by time in therapeutic range (TTR) during the first year after hypertension diagnosi...

Incidence, prevalence, and ketoacidosis at onset of type 1 diabetes in Spain: a systematic review and critical assessment of the available evidence

The incidence, prevalence and onset of type 1 diabetes (T1D) with diabetic ketoacidosis (DKA) in Spain remain insufficiently characterized, despite multiple regional analyses. This study aims to summarize and critically assess epidemiologic data in Spain, incorporating insights f...

Transcription-protein dissociation reveals disrupted cellular stress pathways in the prefrontal cortex of depression and schizophrenia subjects

Abstract Major depressive disorder (MDD) and schizophrenia (SCZ) are severe psychiatric disorders, the molecular mechanisms of which remain incompletely understood. Increasing evidence implicates neuroinflammatory signaling, autophagy dysregulation, and unfolded protein response...

Colorectal Cancer Mortality Following an Organized Fecal Immunochemical Test–Based Screening Program

Importance Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Organized screening programs using the fecal immunochemical test (FIT) have been implemented to reduce CRC mortality through early detection. Objectives To evaluate the association betwee...

Environmental enrichment modulates parvalbumin interneuron deficits and plasticity-related signaling after early postnatal NMDA receptor hypofunction in male rat visual cortex

Abstract Sensory processing deficits in schizophrenia have been linked to dysfunction of cortical inhibitory interneurons, particularly parvalbumin-expressing (PV+) populations. NMDA receptor hypofunction during development is known to disrupt interneuron maturation, but its long...

Usefulness of custom-made orthoses with 3D scanning and printing for the conservative treatment of rhizarthrosis

Background: Trapeziometacarpal osteoarthritis (rhizarthrosis) is often managed with orthopedic orthoses that are prefabricated in various sizes and may be manipulated to be adapted to the patient’s anatomy. Advances in three-dimensional scanning and printing now allow fabrication...