Bernstein Center for Computational Neuroscience Tübingen

Durable clinical and immunologic response to an off-the-shelf EWSR1–FLI1 peptide vaccine in metastatic Ewing sarcoma

Abstract Ewing sarcoma is a rare, fusion-driven malignancy with poor prognosis in the metastatic setting, for which no established immunotherapeutic treatment is currently available. Fusion breakpoints are rational precision immunotherapy targets, yet clinical evidence of immunog...

An elementary form of agency at planetary-scale

Abstract The claim that climate homeorhesis—non-equilibrium steady-state dynamics that underlie Earth’s long-term habitability—depends on an integrated biosphere–climate system capable of acting on its own is central to debates surrounding the Gaia hypothesis. This paper presents...