Beijing Tsinghua Chang Gung Hospital

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Remnant cholesterol–incorporating dual-axis lipid risk stratification using apolipoprotein B and the LDL-C to total cholesterol ratio: a prospective cohort study from the UK Biobank

Atherogenic lipid-related risk may not be fully characterized by a single lipid measure. A dual-axis framework combining apolipoprotein B (ApoB), a measure of atherogenic particle number, with the LDL-C to total cholesterol ratio (LDL-C/TC), a derived measure of cholesterol parti...

Median effective infusion rate (ED50) of continuous cisatracurium for preserving interpretable TceMEP signals during intraspinal tumor resection: a prospective up-and-down sequential allocation study

Intraoperative neurophysiological monitoring (IONM), particularly transcranial electrical stimulation motor evoked potentials (TceMEP), plays a crucial role in preserving motor function during intraspinal tumor resection. However, neuromuscular blocking agents (NMBAs) may attenua...

Derivation of a novel risk assessment model of venous thromboembolism in hospitalized patients

Background Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), significantly contributes to morbidity and mortality among hospitalized patients. Despite the existence of various VTE risk assessment models (RAMs), their performance...

The bidirectional Thymus-Gut Axis: redefining central tolerance in digestive autoimmunity

Digestive autoimmune diseases impose an escalating global burden, largely because current therapies predominantly target downstream inflammation rather than primordial defects in immune tolerance. The thymus establishes central tolerance through stringent T cell selection and thy...

Liposomal Bupivacaine Incisional Infiltration for Postoperative Analgesia After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy: A Randomized Placebo-Controlled Trial

Moderate-to-severe postoperative pain is common after cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). Evidence that liposomal bupivacaine provides clinically important advantages over conventional local anesthetics is inconsistent, and evidence...