Beijing Tsinghua Chang Gung Hospital

Association Between Two Anatomical Landmark Measurements and Tibial Osteotomy Thickness in Total Knee Arthroplasty

AIM: This study preliminarily explores the statistical association between measurements derived from the apex of the tibial tubercle and the most lateral point of the fibular head, as anatomical reference landmarks, and tibial osteotomy thickness in total knee arthroplasty (TKA),...

Discrepancy between knowledge and practice in folic acid supplementation for NTD prevention: a mixed-methods study of Chinese women

Abstract Background Neural tube defects (NTDs) remain a major preventable cause of congenital disability worldwide. Existing evidence suggests a persistent gap between awareness and actual supplementation behaviors among women of childbearing age. Aims To assess folic acid-relate...

Elevated Blood Pressure Is Causally Associated With Larger Subcortical Gray Matter Structure Through Perivascular Clearance Routes

ABSTRACT Background This study aimed to investigate the association between elevated blood pressure (BP) and subcortical gray matter structures, and to elucidate the causality and underlying mechanisms. Methods This study enrolled 1012 participants from a multicenter, population‐...

Retinal nerve fibre layer thickness change in the parapapillary region

Purpose To assess radial changes in the retinal nerve fibre layer thickness (RNFLT) in the temporal parapapillary region. Methods Using radial optical coherence tomographic images of the optic nerve head, we measured in a sample of participants of the population-based Beijing Eye...

Frailty-Related Metabolic Signature in the Association Between Frailty and Coronary Artery Disease: Modification by Genetic Susceptibility

Background Frailty is associated with increased coronary artery disease (CAD) risk, but the circulating metabolic features underlying the frailty–CAD relationship and their interplay with genetic susceptibility remain unclear. This study aimed to identify a frailty-related metabo...

OphthoEvidence Report: Comparative effects of treatments for geographic atrophy secondary to age-related macular degeneration: A protocol for a living systematic review and network meta-analysis

Background Geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD), leads to legal blindness in approximately 16% of affected individuals within 6 years. Numerous trials have evaluated interventions to slow GA progression, and many studies are ongoing....

Association of depressive symptoms with retinal layer thickness: insights from the population-based Beijing eye study 2011

The aim of this study is to investigate the association between depressive symptoms and retinal layer thickness in a population-based adult Chinese cohort. This population-based, cross-sectional study included 2127 eyes of 2127 participants of Beijing Eye Study 2011, free of any...

Review Article: Cancer Surveillance for Early Detection of Liver Cancer in Patients with HBV Infection

BACKGROUND AND AIMS: Chronic hepatitis B virus (HBV) infection remains a major cause of hepatocellular carcinoma (HCC). Although antiviral therapy reduces cirrhosis and liver failure, HCC may still develop in patients with HBV, including in non-cirrhotic livers. This review aimed...

Leveraging Metamaterial‐Inspired Wireless Resonator for Reliable Quantitative MRI at 1.5T: Linearity, Bias, and Repeatability Assessment

ABSTRACT The accuracy of quantitative magnetic resonance imaging (qMRI) largely depends on the image signal‐to‐noise ratio (SNR). In recent years, studies on metamaterials in MRI have shown that they can significantly improve image quality through weak coupling with the body coil...

BAP31 attenuates acute lung injury by inhibiting ferroptosis through activation of the AKT/GSK3β/Nrf2 pathway in the alveolar epithelial cells

Abstract Background: Ferroptosis plays an important role in the progression of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Although B-cell receptor-associated protein 31 (BAP31) has been shown to mitigate lung inflammation and oxidative stress, its involvement in fe...

Interventional strategies for inferior phrenic artery management in yttrium‑90 selective internal radiation therapy for hepatocellular carcinoma: A single‑center retrospective study

Extrahepatic collateral supply from the inferior phrenic artery (IPA) is frequently observed in patients with hepatocellular carcinoma (HCC) undergoing yttrium-90 selective internal radiation therapy ( 90 Y-SIRT). Currently, no standardized IPA management algorithm has been estab...

Design and application of an intelligent laboratory medicine teaching management system based on smart spreadsheets

Clinical laboratory medicine education involves multiple instructors, repeated small-group teaching activities, attendance tracking, formative evaluation, workload calculation, and timely feedback. Conventional learning management systems may require substantial customization to...

The Glycolysis-NETosis Feedback Loop: A Metabolic-Immune Axis in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory condition of the gastrointestinal tract with rising global incidence. Neutrophils, as first-line responders to intestinal inflammation, release neutrophil ex...

Efficacy and Safety Analysis of Single‐Port Robotic Assisted Cholecystectomy Using a Novel Surgical Platform: A Bicentre, Single‐Arm, Prospective Phase II Clinical Study

ABSTRACT Background Single‐port robotic cholecystectomy offers minimally invasive benefits. This trial evaluated the feasibility and safety of a novel system, MicroPort SA‐1000. Methods In this dual centre, single‐arm, prospective study, eligible patients underwent single‐port ro...

Automated CT segmentation of diffuse pseudomyxoma peritonei lesions using a hybrid deep learning model

Abstract Purpose To develop and externally validate DATUnet—a hybrid deep learning framework integrating DenseBlock encoding, atrous spatial pyramid pooling (ASPP), and a lightweight Transformer bottleneck—for automated segmentation of diffuse pseudomyxoma peritonei (PMP) lesions...

Label-free dynamic cell imaging of fresh ex vivo spinal meningiomas: a nine-case optical-pathological correlation study with specimen-level H&E references

Spinal meningioma subtype and grade still rest on haematoxylin and eosin (H&E) morphology, but permanent sections become available only after fixation and embedding, and intraoperative assessment of fresh tissue relies mainly on frozen section. Dynamic cell imaging (DCI), a label...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

MRI Tract‐Based Quantitative Susceptibility Mapping of Limbic White Matter Alterations in Preeclampsia

BACKGROUND: Preeclampsia is associated with long-term cerebrovascular and cognitive risk, but tract-level white matter (WM) involvement remains incompletely characterized. PURPOSE: To investigate whether preeclampsia is associated with tract-level WM susceptibility alterations on...

Multiple Myeloma Complicating Breast Cancer During Treatment: A Case Report

Research Background: Breast cancer is a malignant tumor that threatens women’s health. Among breast cancer patients, about 4.2% to 17% may suffer from multiple primary malignant neoplasms. Cases of patients suffering from both breast cancer and multiple myeloma are relatively rar...

Metabolic-extracellular matrix crosstalk in hepatocellular carcinoma: mechanisms and targeted intervention

Bidirectional crosstalk between metabolic reprogramming and extracellular matrix (ECM) remodeling in hepatocellular carcinoma (HCC) constitutes an important metabolic–ECM regulatory network that contributes to HCC progression. Metabolic derangements disrupt ECM deposition, crossl...