Beijing Tian Tan Hospital

Terahertz-based prognostic framework for glioma: from spectral features to patient-level prognostic assessment

In glioma, accurate prediction of recurrence and survival is essential for clinical decision-making and individualized management. However, current prognostic tools do not fully capture outcome heterogeneity, and convenient approaches for early postoperative prognostic evaluation...

Balancing privacy and performance: the impact of facial defacing on AI in medical imaging

Background Recent NIH Data Management and Sharing (DMS) policy updates and NIH controlled-access data security requirements have increased attention to facial anonymization and controlled-access handling of shared head imaging data. This is particularly relevant for datasets subm...

Transcriptional Profiling of Growth Hormone–Secreting Pituitary Adenoma Stem‐Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications

ABSTRACT Growth hormone–secreting pituitary adenoma (GHPA) can cause excessive growth hormone production, which can lead to clinical symptoms such as acromegaly. Tumor stem cells (TSCs) are postulated to play a significant role in the development of GHPA. We performed RNA sequenc...

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

Longitudinal gut microbiome dynamics in neurosurgical ICU patients: Enterococcus expansion as a feature of microbial restructuring

Abstract Background Gut microbiota alterations are commonly observed in critical illness, but their temporal dynamics in neurosurgical ICU patients remain insufficiently characterized. This study aimed to describe postoperative microbial trajectories and their clinical context du...

A retrospective comparative study of chronic subdural hematoma in patients with or without decreased level of consciousness

Abstract Background In this retrospective cross-sectional study, we aimed to investigate the effects of preoperative decreased level of consciousness (DOC) on 6-month outcome and the risk factors that compromised the consciousness at admission in patients with chronic subdural he...

Antioxidant nanozymes for regenerative medicine: mechanisms, design, and applications in tissue repair

Natural antioxidant enzymes play a central role in regulating oxidative stress within living organisms. During tissue repair following injury, these enzymes act synergistically to scavenge excess reactive oxygen species and maintain cellular redox homeostasis, thereby supporting...