Beijing Tian Tan Hospital

Intratumoral and Peritumoral Functional Connectivity Reveals Network‐Level Signatures of Glioma

ABSTRACT Gliomas are recognized as network‐level diseases that remodel functional connectivity across the brain. Using resting‐state functional MRI (rs‐fMRI) data from 306 patients with pathologically confirmed glioma at two hospitals, we delineated individualized intra‐ and peri...

Low-Dose Glucocorticoids Adjunctive to Flow Diverter Therapy for Unruptured Intracranial Aneurysms Improve Cerebrovascular Outcomes

Abstract Flow diverter (FD) implantation is standard for unruptured intracranial aneurysms (UIAs), but cerebrovascular complications persist. This nested study within a prospective multicenter cohort evaluates whether short-term, low-dose glucocorticoid use is associated with cer...

Neutrophil to Lymphocyte Ratio and Neurological Outcome in Ischemic Stroke at 4.5 to 24 Hours: A Post Hoc Analysis of TRACE-III Trial

Whether neutrophil to lymphocyte ratio (NLR), as a marker of increased inflammatory response, modifies the efficacy and safety of tenecteplase is uncertain in patients 4.5–24 h after stroke onset. We investigated this in the Tenecteplase Reperfusion Therapy in Acute Ischemic Cere...

PET-based evaluation of short-term amyloid-β clearance and predictive factors in real-world Alzheimer's disease patients treated with lecanemab

Background Alzheimer's disease (AD) is a common progressive neurodegenerative disorder. Lecanemab, an anti-amyloid-β (Aβ) monoclonal antibody, is approved for AD treatment, but real-world efficacy and optimal PET application strategies remain incompletely defined. Objective To in...

Global epidemiological and genetic burden of rare neurological diseases in children

We assessed the global burden of rare childhood neurological diseases from 1990 to 2021 and projected trends to 2050 using Global Burden of Disease data, alongside an analysis of the genetic burden from ClinVar. Four neurological conditions were classified as rare childhood neuro...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

EXPRESS: Association between Neurovascular Network Dysfunction and Poor Sleep Quality in Patients with Cerebral Small Vessel Disease

BACKGROUND/HYPOTHESIS: Poor sleep quality is frequently reported among patients with cerebral small vessel disease (CSVD), but its neurovascular correlates remain unclear. We examined exploratory associations between multidomain neurovascular network (NVN) measures and poor sleep...

Literature review of myasthenia gravis complicated by myocardial damage

Background: Myasthenia gravis (MG) is a chronic autoimmune disorder predominantly driven by pathogenic autoantibodies directed against postsynaptic acetylcholine receptors, impairing neuromuscular transmission. Although cardiovascular complications remain relatively uncommon amon...

Diagnostic efficiency of serum-based fourier transform infrared spectroscopy for brain tumors: a systematic review and meta-analysis

Fourier transform infrared (FTIR) spectroscopy has been widely explored as a non-invasive diagnostic tool in oncology. However, the overall diagnostic performance of serum-based FTIR spectroscopy for brain tumor detection has not been systematically evaluated. This meta-analysis...

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

ABSTRACT Ductal carcinoma in situ (DCIS) is a non‐invasive precursor of invasive ductal carcinoma (IDC), yet the biological mechanisms underlying the transition from DCIS to IDC remain incompletely understood. Here, we integrate spatial transcriptomics, single‐cell RNA sequencing...

Association between A Body Shape Index (ABSI) and mortality risk across populations with different sedentary time: a large-scale cohort study

A Body Shape Index (ABSI) is a simple and efficient metric for assessing adiposity, and sedentary behaviour is a common unhealthy practice. Both factors have been demonstrated to be associated with mortality risk. However, research on the influence of sedentary time on the associ...

circRNADisease v3.0: an updated resource for high-quality, experimentally supported circRNA-disease associations.

Systematic integration of circular RNA (circRNA)-disease associations is essential for elucidating the roles of circRNAs in disease pathogenesis and evaluating their potential as biomarkers and therapeutic targets. circRNADisease was established as a manually curated database of...

Urine metabolomics reveals key pathways supporting neuronal regeneration and consciousness recovery in disorders of consciousness

Disorders of consciousness (DoC) are debilitating conditions resulting from severe brain injury, requiring not only structural preservation but also active neuronal regeneration for recovery. These regenerative processes are metabolically demanding and can be tracked through syst...

sTREM2 and GFAP mediated the association of cerebrospinal fluid GLP-1R with tau pathology in alzheimer’s disease

Glucagon-like peptide-1 receptor (GLP-1R) is involved in metabolic regulation and has also been implicated in neuroprotection and the modulation of neuroinflammatory processes in the central nervous system. GLP-1R has therefore emerged as a potential therapeutic target for Alzhei...

From endovascular therapy to perivascular therapy: A new concept and perspective

The cardiovascular system relies on an organ-spanning vascular network not only for transport but also for systemic homeostatic control. Surrounding the vessel wall is a complex perivascular microenvironment, including the vasa vasorum, autonomic and sensory nerves, perivascular...

Continuous glycemic phenotype derived from latent class mixed models predicts 28-day mortality after traumatic brain injury: a two-cohort study

Abstract Acute stress hyperglycemia is common after traumatic brain injury (TBI) and is associated with adverse outcomes. However, the prognostic value of longitudinal glucose trajectories during the early ICU stay remains poorly characterized, and whether post-TBI glycemic dynam...

Development and internal validation of a model predicting four year cardiovascular kidney metabolic syndrome stage progression

Abstract To develop a model for predicting cardiovascular-kidney-metabolic (CKM) syndrome stage progression in middle-aged and older Chinese adults and to evaluate the incremental predictive value of routinely available clinical variables beyond baseline CKM stage. This study use...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Ticagrelor-Aspirin With Thrombolysis by Infarct Patterns in Moderate Ischemic Stroke: TAPIS Subgroup Analysis

BACKGROUND: Whether diffusion‑weighted imaging infarction patterns influence the efficacy and safety of early oral ticagrelor‑aspirin with intravenous thrombolysis in moderate acute ischemic stroke is uncertain. We assessed treatment effects by infarction pattern in this thrombol...

Efficacy and Safety of Stent-Assisted Coiling Versus Coiling Alone for Ruptured Multilobed Aneurysms: A Multicenter Study

BACKGROUND: Ruptured multilobed intracranial aneurysms present significant procedural challenges and high recurrence risks in endovascular treatment due to complex geometry and turbulent hemodynamics. Currently, the safety and long-term efficacy of stent-assisted coiling (SAC) ve...