Beijing Normal University

ESAT-6 and CFP-10 in tuberculosis: bridging virulence to diagnostic applications

Tuberculosis (TB) remains a major global public health challenge. Accurate detection of Mycobacterium tuberculosis ( Mtb ) infection, particularly latent tuberculosis infection (LTBI), is essential for targeted preventive treatment and progress toward TB elimination. The traditio...

Domain-Wall-Mediated Ultralow-Barrier Sliding and Pinning in Ferroelectric Moire Superlattices Revealed by Machine Learning

Abstract Sliding ferroelectrics built from stacked nonpolar monolayers enable out-of-plane polarization and unconventional switching via interlayer sliding, yet the microscopic sliding dynamics remain unclear. Using machine-learning molecular dynamics, we reveal spontaneous, ther...

Hydroclimatic associations with vegetation resilience in China's Loess Plateau

Understanding how recovery-related vegetation resilience varies along hydroclimatic gradients is important for evaluating vegetation sustainability in water-limited regions. Here, using satellite-derived vegetation indices and resilience metrics derived from critical slowing down...

普通话文白异读的形成机制与教学启示 − 基于 2016 年《普通话异读词审音表 (修订稿)》条目

提要 普通话以北京语音为标准音, 但其语音系统并非单一共时方言的直接反映, 而是在复杂历时演变中逐步定型, 其中 “文白异读” 尤能体现多重层次的沉积与语体分工。本文以 2016 年《普通话异读词审音表 (修订稿)》为主要依据, 最终整理出普通话中常见的 23 个文白异读条目。本文在音韵学视角下, 运用历史...

Effective metric for bound state in an effective-one-body theory based on the third-post-Minkowskian approximation

Abstract The effective-one-body (EOB) framework, originally formulated within the post-Newtonian (PN) expansion, is central to modeling and interpreting gravitational-wave signals. Recent developments have incorporated the post-Minkowskian (PM) expansion into EOB theory. In this...

Outpatient versus telephone follow-up and blood pressure control in China: a longitudinal study in primary care

As the population ages, long-term standardized management of hypertension has become a critical task for primary healthcare systems. Telephone follow-up is widely used as a supplementary approach to outpatient care; however, its long-term effectiveness in real-world settings rema...

Ecosocial environments and chronic lower respiratory disease mortality: a nationwide ecological study

Chronic lower respiratory disease (CLRD) is a leading cause of death in the United States and imposes a substantial economic burden. Ecosocial environments are closely linked to population health, yet nationwide evidence on their associations with CLRD mortality remains limited....

Self-reported outcomes and associated factors among patients with cancer completing Mongolian mind-body interaction therapy: a cross-sectional study

Introduction Patients with malignant tumors face physical illness and psychological distress. Mongolian mind-body interaction therapy (MMBIT) is a group-based intervention combining modern psychology with traditional Mongolian medicine. As a complementary oncology approach, MMBIT...

Design, Synthesis, and Evaluation of 99mTc-Labeled Proline Isonitrile Derivatives with Optimized Linker Lengths for Tumor SPECT Imaging

Abstract Amino acid metabolic imaging is among the important research directions in tumor molecular imaging. The highly active metabolism of proline in tumors, together with the abnormal expression of its key enzymes, makes it a promising target for tumor molecular imaging. To de...

Sublethal silver nanoparticle exposure promotes an Eut-dependent shift in Escherichia coli–Staphylococcus aureus competition

Envelope-targeting antimicrobials are widely detected in wastewater and engineered water systems, yet their potential to reshape interspecies interactions through membrane-derived metabolites remains poorly understood. Here, we investigated whether sublethal silver nanoparticles...

Intrinsic functional architecture predicts remote motor cortical excitability changes induced by intermittent theta-burst stimulation

Repetitive transcranial magnetic stimulation (rTMS) modulates cortical excitability both locally and remotely through connected regions. However, how intrinsic functional architecture influences these remote effects remains unclear. Leveraging multi-site stimulation (targeting th...

Topology-preserving river vectorization via HydroSAM and differentiable graph optimization under coarse labels

Accurate river-network extraction supports global hydrological management and environmental monitoring. Automated extraction from remote-sensing imagery remains challenging because river morphology is highly variable, fine tributaries have weak visual signals, canopy and infrastr...

Cumulative Duration and Habitat Selection Across the Annual‐Cycle Stages: Links to Human Modification in Two Declining Shorebirds

ABSTRACT Although tracking studies have identified shorebird migration routes along the East Asian–Australasian Flyway, how cumulative duration and habitat selection vary across annual‐cycle stages and relate to human modification of habitats remains poorly understood. We integra...

Assessing synergies and trade-offs among water yield, sediment retention, and carbon storage in Yunnan Province, China

Understanding the spatiotemporal dynamics and interactions of ecosystem services (ES) is critical for regional ecological governance. Taking Yunnan Province, a key ecological barrier in southwestern China, this study quantified water yield (WY), sediment retention (SR), and carbo...

“Drugs are a deep scar on the Chinese nation”: Discursive strategies of (de)legitimation regarding the sealing of drug use records in the digital sphere

The recent revision of China’s Public Security Administration Punishments Law, which permits the sealing of public-security administrative violation records, including drug-use records, has generated considerable fierce online debate. Designed as a step to reduce structural stigm...

Phase 1 Dose-Escalation Study of the Rapid-Clearance Radioligand [ 177 Lu]Lu-P17-087 in Metastatic Castration-Resistant Prostate Cancer: Dosimetry, Safety, and Preliminary Efficacy

Given the rapid systemic clearance and favorable kinetic profile of the novel DOTA(GA)2-conjugated ligand [177Lu]Lu-P17-087, this phase 1 study aimed to systematically evaluate the safety, pharmacokinetics, dosimetry, and preliminary antitumor activity of escalating therapeutic a...

ACC-projecting claustral neurons are required during cue pre-exposure for latent inhibition

In a noisy world, learning to ignore stimuli that repeatedly occur without consequence is essential for adaptive behavior. Latent inhibition, in which prior inconsequential cue exposure slows subsequent associative learning, captures this capacity. The claustrum is densely interc...

Impacts of Temporally Compounding Hot-Dry Events on Agricultural Droughts via Vegetation in the Yangtze River Basin

Abstract Vegetation has an important impact on hydroclimatic conditions via its impacts on water, energy, and carbon exchanges of the terrestrial land surface. The vegetation greening of earlier spring can cause summer drying of soil moisture, reflecting the trans-seasonal lagged...

Compound food failure on a deteriorated mast system drives Japan’s bear conflict crisis

Climate change is recognized as a key amplifier of human-wildlife conflict, yet the underlying mechanism remains poorly understood. Japan’s 2025 bear crisis, which produced 232 casualties, has been widely attributed to rapid population growth, but demographic processes are far to...

The Relationship Between Hostile Interpretation Bias and Aggression in Adults: A Systematic Review and Three-Level Meta-Analysis

Hostile interpretation bias is a key cognitive factor associated with aggression; however, empirical research findings among adult populations remain inconsistent and lack systematic integration. This study aimed to quantitatively synthesise the association between hostile interp...