Australian Regenerative Medicine Institute

Specific targeting of MR1-antigen complexes using nanobodies

T cell receptor mimic (TCRm) antibodies that bind peptide–human leukocyte antigen complexes have great therapeutic potential. Major histocompatibility complex class I–related protein 1 (MR1) exhibits limited polymorphism and presents conserved metabolites, such as 5-OP-RU, derive...

Strategies for integrating artificial intelligence and cognitive assessment to predict disability progression in relapsing-remitting multiple sclerosis: A model development study

Serial cognitive assessment in multiple sclerosis can help identify patients at higher risk of disability progression, but high dimensionality of reaction-time data makes analysis challenging. We developed a method to convert longitudinal reaction-time data into images and applie...

Ethnography of Singing for Breathing in COPD and ILD: Understanding Group Dynamics and Experiences

Background/Aim A growing body of evidence exists detailing the benefits of singing for lung health programs in improving participants’ breathlessness and quality of life. However, the pandemic prompted a shift to online delivery, and there is limited understanding of how this mod...

ON THE DIAMETER OF INTERSECTION GRAPHS OF FINITE GROUPS

Abstract The intersection graph Δ G $\Delta _G$ normal upper Delta Subscript upper G of a finite group G $G$ upper G is a simple graph with vertices the nontrivial proper subgroups of G $G$ upper G , and an edge between two vertices if their corresponding subgroups intersect nont...

Contesting Collecting: Indigenous Material Cultures

This dialogue explores how we understand and contest the collecting of Indigenous material cultures. Poskett, using several case studies explores how Indigenous and non-Indigenous perspectives can complicate fixed notions of materiality. Russell, drawing on her own heritage and i...

Why should we study Arabic theatre?

Arabic theatre, as an academic discipline is one of the most understudied genres. Despite its rich and sophisticated history, theatre failed to capture the intellectual attention of scholars in Arabic Cultural Studies or Literary Translation Studies. In this manifesto, I argue th...

Implementing Sequential Analysis for Vaccine Safety Surveillance in Victoria, Australia

This preprint presents an end-to-end implementation framework for MaxSPRT-style sequential analysis in vaccine safety surveillance, using the Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC) system in Victoria, Australia, as the operational setting....

A conserved tyrosine motif encodes a structural vulnerability controlling stability and activity across J-domain proteins

J-domain proteins (JDPs) direct Hsp70 functions through a conserved J-domain that engages and activates Hsp70. JDPs support proteostasis and are linked to development and disease, yet how they are regulated remains unclear. Here, we identify a conserved tyrosine motif outside the...

fishROI: a specialized workflow for semi-automated muscle morphometry analysis in teleosts

Abstract Background Quantitative histological analysis of skeletal muscle morphometry provides critical insights into muscle physiology but remains labor-intensive and technically demanding. While recent developments in machine learning-based image segmentation techniques have fa...

scTransMIL bridges patient-level disease states and single-cell transcriptomics for cancer screening and heterogeneity inference

Single-cell sequencing offers profound insights into tumor complexity. However, reliably linking individual cellular profiles to overall sample-level phenotypes remains computationally challenging, particularly when cell-specific annotations are absent. This disconnect limits the...

Physicochemical effects of bicarbonate-buffered solution versus compound sodium lactate during major abdominal surgery: A randomized, open-label, non-inferiority trial

Introduction Bicarbonate-buffered crystalloids avoid exogenous lactate and have physicochemical properties distinct from compound sodium lactate (CSL), but direct comparative evidence during major abdominal surgery remains limited. Methods This single-center, open-label, randomiz...

Young children’s early strategic thinking about partitive division

This paper presents an analysis of the early strategic thinking of 94 young children aged between 5 years 7 months and 6 years 5 months. These children were participants in a larger study of children in their first year of formal schooling in Australia at the time of the intervie...

Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr‐Pyrazole Chemistry

The glycopeptide antibiotics (GPAs) remain clinical antibiotics used against drug‐resistant Gram‐positive infections. The discovery of GPAs continues, with new type IIa and V GPAs, the kineomicins, the rimomycins, and corbomycin, being recently identified. Despite this larger rep...

Ikarians in South Australia 1900–1945

Yianni (John) Cartledge’s Ikarians in South Australia constitutes an impressive achievement in meticulously detailing Ikarian settlement in Australia in the first half of the twentieth century, dra...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer

Abstract Telomere maintenance genes are closely related to colorectal cancer (CRC) development and progression. However, the potential influence of telomere maintenance-related genes (TMRGs) on the prognosis of CRC and their clinical relevance remains insufficiently explored. Uti...

Thalamocortical network dynamics can explain visual impulse responses and perceptual echoes

Although temporal information is ubiquitous in natural vision, the cortex shows strong intrinsic rhythmicity. Recent electroencephalogram (EEG) studies have revealed a component of the visual impulse response function (IRF) resembling a narrow alpha-band (7–13 Hz) filter with a s...

Candida auris uses nutrient sensing to modulate virulence and host immune responses

The emergence of Candida auris as a pathogen required host adaptation and evasion of mammalian immunity, but the mechanisms are poorly understood. We discovered that C. auris uses nutrient sensing to tune its virulence traits and modulate immune activation in changing environment...

Structure-guided allosteric modulation of the delta opioid receptor

Abstract Opioid analgesics remain essential for pain management but are associated with significant adverse effects, including respiratory depression, tolerance, and dependence. The δ-opioid receptor (δOR) represents a promising therapeutic target for developing safer opioid anal...

The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate

Neuronal-glial cell fate switch during forebrain development is highly regulated. DLX transcription factors are necessary for promoting GABAergic interneuron differentiation and migration but the mechanisms for concomitant repression of glial fate in neural progenitors remain elu...