Australian Regenerative Medicine Institute

Structure-guided allosteric modulation of the delta opioid receptor

Abstract Opioid analgesics remain essential for pain management but are associated with significant adverse effects, including respiratory depression, tolerance, and dependence. The δ-opioid receptor (δOR) represents a promising therapeutic target for developing safer opioid anal...

The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate

Neuronal-glial cell fate switch during forebrain development is highly regulated. DLX transcription factors are necessary for promoting GABAergic interneuron differentiation and migration but the mechanisms for concomitant repression of glial fate in neural progenitors remain elu...

Large Language Model for Verilog Code Generation: Literature Review and the Road Ahead

Code generation represents a critical intersection of Software Engineering (SE) and Artificial Intelligence (AI). Within this broader landscape, Verilog, as a representative hardware description language (HDL), is fundamental to Electronic Design Automation (EDA), recent research...

A systematic review of early neuroimaging and neurophysiological biomarkers for post-stroke mobility prognostication

Abstract Background Accurate prognostication of mobility outcomes is essential to guide rehabilitation and manage patient expectations. The prognostic utility of neuroimaging and neurophysiological biomarkers remains uncertain when measured early post-stroke. This systematic revi...

Impact of socioeconomic status on treatment and survival in multiple myeloma in Australia

<title>Abstract</title> Outcomes in multiple myeloma (MM) have improved significantly but remain heterogeneous. We assessed the impact of non-biological social determinants of health on treatment and survival outcomes in Australia using data from the Australian and New Zealand My...

Stellar Interpretation of Meteoritic Data and PLotting for Everyone (SIMPLE): Isotope Mixing Lines for Six Sets of Core-collapse Supernova Models

Abstract Bulk meteorites and their inclusions exhibit, for many chemical elements, isotopic variability produced by nucleosynthetic events in stars and supernovae before the formation of the Sun. While the exact astrophysical origins of these variations are still a matter of deba...

Relationship between neck weakness in motor neurone disease and respiratory function: a retrospective study

AIMS: The primary aim was to explore the relationship between neck weakness in people with motor neurone disease (MND) and their respiratory function. The secondary aim was to identify whether neck weakness can be a prognostic factor. METHODS: This was a retrospective observation...

Historical Anti-Fascism and Right-Wing Voting in Italy

We study how anti-fascist opposition during Mussolini’s dictatorship affects post-war support for right-wing parties in Italy. We construct a measure of anti-fascism from the universe of recorded opponents, and use newly digitized historical data to resolve simultaneity between t...

Metabolic reprogramming enables transient survival and envelope remodelling in Staphylococcus aureus under dalbavancin treatment

Clinical failure of antibiotic therapy can occur in the absence of measurable resistance, yet the biological basis of this discordance remains poorly understood. Here, we identify a transient survival phenotype that limits dalbavancin efficacy and may contribute to treatment fail...

Assessing Vancomycin‐Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry

Staphylococcus aureus strains have emerged with resistance mechanisms that reduce the efficacy of last resort antibiotics and evade the immune system. One strategy to combat antimicrobial resistance is to modulate host immunity to eliminate infections more effectively. This has l...

Building inclusive learning communities: the collaborative role of parents and school leaders in supporting students with additional needs

Inclusive education is widely endorsed as a policy priority; however, less is known about how school leaders practically enable collaboration with parents to support inclusive schooling. This qualitative study examines how secondary school leaders enact and sustain collaboration...

Development of an instrument for measuring university students’ motivation for sustainability engagement using self-determination theory

Sustainability education has become an important focus of higher education globally. However, the factors influencing students’ motivation to engage in sustainability-related activities, both within formal educational settings and in their broader communities, remain relatively u...