Army Medical University

Circulating Protein Biomarkers for Primary Cardiomyopathy: Evidence from Mendelian Randomization and Clinical Validation

BACKGROUND: Primary (non-ischemic) cardiomyopathy poses diagnostic challenges due to phenotypic heterogeneity and non-specific clinical presentation, and commonly used circulating biomarkers have limited disease specificity. The aim was to prioritize mechanism-informed plasma bio...

Auditory brainstem response deficits precede and are associated with subsequent auditory cortical amyloid burden in male APP/PS1 mice

Background Auditory dysfunction is considered one of the early manifestations of Alzheimer's disease (AD). However, its evolutionary characteristics with the progression of AD have not been fully studied, and the temporal relationship between this sensory impairment and the typic...

Health-convergence-based muscle synergy variability for quantifying neuromuscular control responses evoked by upper limb rehabilitation robot training in stroke patients

Upper limb rehabilitation robot-assisted training (UE-RAT) facilitates post-stroke motor recovery. Its efficacy is evaluated using clinical scales. However, these scales mainly reflect overall motor impairment and functional performance, lacking indices to assess patients’ neurom...

Graph neural network-based service migration decision in vehicular networks

Abstract The rapid development of the Internet of Vehicles (IoV) has led to an exponential increase in the number of latency sensitive and computationally intensive tasks. Due to the limitations of onboard computing resources in vehicles, offloading these tasks generated during v...

School-based hygiene intervention to prevent Helicobacter Pylori infection among children (SHIP HOPE): a cluster-randomized controlled trial

Helicobacter pylori ( H. pylori ) is a major cause of gastric cancer and is typically acquired during childhood. Preventing infection in uninfected children is a promising strategy; however, the effectiveness of hygiene-based interventions remains uncertain. This study aimed to d...

LIDR-TB: large language model-integrated platform for traceable drug repurposing in tuberculosis

Tuberculosis (TB) remains a global challenge exacerbated by the ongoing emergence of drug-resistant strains. Although drug repurposing offers a cost-effective strategy to expedite therapeutic discovery, its application is impeded by the lack of unified, disease-specific framework...

Aconitine accidental poisoning: two case reports and literature review

Abstract Introduction Chinese Herbal Medicine (CHM) is widely integrated into clinical practice across Asia and other regions for disease treatment and health maintenance. Aconitine, a potent diterpenoid alkaloid derived from plants of the Aconitum genus (e.g., Aconitum carmichae...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

Induction of transferrin receptor 1-mediated ferroptosis by ultrasound-triggered microbubble destruction sensitizes glioblastoma to radiotherapy

Abstract Ultrasound-triggered microbubble destruction (UTMD), a non-invasive technique, has been proposed as a promising means of improving the efficacy of radiotherapy against glioblastoma (GBM); however, the underlying mechanisms remain to be fully clarified. Here, UTMD was sho...

Biohybrid M13 phage backpacks for active blood–brain barrier traversal and precision central nervous system leukemia treatment

Abstract Central nervous system (CNS) leukemia remains a major clinical challenge in acute lymphoblastic leukemia, largely due to the restrictive nature of the blood–brain barrier (BBB), which severely limits therapeutic delivery and contributes to high relapse rates and poor pro...

Modulating task-outcome value to mitigate real-world procrastination via noninvasive brain stimulation

Procrastination is a prevalent behavioral problem associated with individual health and societal productivity. A leading model posits that procrastination reflects an imbalance between task aversiveness and the pursuit of positive task outcomes, yet this theoretical framework has...

Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy

Anoikis presents an alternative scheme for suppressing tumor metastasis. While limited by off-target effects, rapid degradation, and reactive oxygen species (ROS) accumulation, anoikis resistance remains a persistent challenge for current tumor therapy. The use of external and en...

From Metabolic Dysfunction to Vascular Remodeling

Subclinical cardiovascular disease (SCVD) encompasses a spectrum of vascular abnormalities that emerge well before the onset of overt cardiovascular events. Although a wide range of metabolic, inflammatory, and vascular markers have been associated with SCVD, current assessment s...

Edge-centric functional diversity alterations and associated transcriptomic profiles of pain and vertigo in the migraine spectrum

Abstract Background The migraine spectrum exhibits substantial clinical heterogeneity, encompassing pain-dominant, vertigo-dominant, and pain-vertigo overlapping manifestations, as represented here by migraine without aura (MwoA), a clinically defined adult vertigo-dominant recur...

Clinical characteristics and risk factors of recurrence for Pseudomonas aeruginosa -associated fracture-related infection following surgical treatment

Aims Pseudomonas aeruginosa (PA), a prevalent Gram-negative pathogen in fracture-related infections (FRIs), presents huge therapeutic challenges due to biofilm formation and multidrug resistance (MDR). Evidence-based guidelines for PA-associated FRI (PA-FRI) remain limited. The a...

Intranasal dexmedetomidine on the effect of postoperative sleep quality for patients undergoing on-pump cardiac surgery: a prospective double-blinded randomized control study protocol

Sleep disturbances are highly prevalent in the perioperative period and are associated with poor recovery outcomes. This is particularly relevant for cardiac surgery patients, among whom sleep architecture disorders are common postoperative complications. Dexmedetomidine, a selec...

Global Trends in Heart Failure Self-Care Research: A Bibliometric and Visual Analysis

Background: Adequate patient self-care is fundamental to effective heart failure (HF) management and is endorsed by international guidelines to improve clinical outcomes. Despite a growing body of evidence, the global research landscape, including publication trends, collaborativ...

Exposure to Size-Fractioned Ambient Particles Associated with Alterations in Gut Microbiome and Pro-Atherosclerotic Biomarkers in Young Adults

Abstract Background: Ambient fine and ultrafine particles are linked to the progression of atherosclerotic cardiovascular diseases, wherein gut microbiome may play a critical role. However, the underlying mechanisms and relevant metabolic pathways are not yet fully understood. Ob...

Potential roles of short-chain fatty acids in chronic obstructive pulmonary disease from the gut-lung axis perspective: an exploratory trend summary and discussion on biological mechanisms based on current evidence

Short-chain fatty acids (SCFAs) have been proposed as mediators of the gut-lung axis in chronic obstructive pulmonary disease (COPD). However, the human evidence is limited and heterogeneous across disease states and specimen types. We therefore synthesized the available evidence...

Neural-specific UBAP2L deficiency causes developmental delay and cortical abnormalities in mice

Rare UBAP2L variants have been linked to neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD), but the role of UBAP2L in brain development remains unclear. Here, we generated neural-specific conditional knockout mice for Ubap2l using Nestin-Cre system, incl...