Antalya Eğitim ve Araştırma Hastanesi

The Interstitial Homeostatic Early-Warning System: Rethinking Preventive Laboratory Testing

Preventive laboratory testing primarily identifies established metabolic abnormalities, organ dysfunction, or systemic inflammation. This Perspective proposes that some pathological processes may first produce detectable disturbances within the tissue interstitium before conventi...

Long-Term Major Adverse Kidney and Cardiovascular Events in Predialysis Chronic Kidney Disease: A Real-World Cohort Study

Background and Objectives: Long-term renal and cardiovascular outcomes represent major clinical burdens in predialysis chronic kidney disease (CKD). This study aimed to evaluate the long-term incidence of and clinical factors associated with major adverse kidney events (MAKEs) an...

Prognostic Value of Systemic Inflammation Markers and Clinical Factors in Grade 4 Diffuse Glioma: A Multicenter Retrospective Real-World Study

Background/Objectives: Systemic inflammation contributes to tumor growth and spread. We aimed to evaluate the association of pretreatment inflammatory indices and clinical and laboratory factors with survival in newly diagnosed grade 4 diffuse glioma. Methods: A total of 120 pati...

Absorbable tacker fixation versus non-fixation in totally extraperitoneal inguinal hernia repair: a prospective randomized study on postoperative pain and quality of life

The role of mesh fixation in laparoscopic totally extraperitoneal (TEP) inguinal hernia repair remains controversial. While fixation may increase postoperative pain, concerns about recurrence in larger defects prevent its complete abandonment. This study aimed to compare absorbab...

Diagnostic performance of Alvarado versus Karaman scoring systems in acute appendicitis: A retrospective comparative study

Aims: Acute appendicitis (AA) is the most common cause of acute abdomen requiring surgical intervention. This study aimed to compare the diagnostic accuracy and consistency of the classic Alvarado score, which is widely used worldwide in the diagnosis of AA, with the more recentl...

Real-world outcomes of children with first relapsed acute lymphoblastic leukemia treated according to the ALL-IC REL 2016 guideline in Türkiye

Relapsed acute lymphoblastic leukemia (ALL) remains a major challenge in pediatric oncology, particularly where access to modern immunotherapies is limited. This national multicenter study evaluated real-world outcomes of children with first relapsed ALL treated according to the...

Ability of the HALP Score to Predict Cardiac Implantable Electronic Device‐Related Complications

BACKGROUND: The hemoglobin, albumin, lymphocyte, and platelet score (HALP) is a recently defined score that indicates patients' inflammation and nutritional status. This score is associated with poor outcomes in cardiovascular diseases. We aimed to examine the relationship betwee...

Dynamic Changes in Serum Neutrophil Gelatinase-Associated Lipocalin for Discrimination of Creatinine-Defined Acute Kidney Injury After Laparoscopic Sleeve Gastrectomy: A Prospective Observational Cohort Study

Background/Objectives: Acute kidney injury (AKI) may occur after laparoscopic sleeve gastrectomy (LSG) as a result of obesity-related renal vulnerability, pneumoperitoneum-induced changes in renal perfusion, and perioperative hemodynamic stress. Serum creatinine remains the stand...

Longitudinal Assessment of Diastolic Function and Myocardial Strain in Type 2 Diabetes: A Comparison of Empagliflozin and Linagliptin

OBJECTIVE: The cardiovascular effects of sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors have attracted increasing interest in patients with type 2 diabetes mellitus. This study aimed to compare the time-dependent effects of empagliflozin and linag...

Do Early Prognostic Measures Differentiate Mechanisms of ICU Death in Aneurysmal Subarachnoid Hemorrhage? An Analysis of Fatal Outcomes

Background/Objectives: In aneurysmal subarachnoid hemorrhage (aSAH), intensive care unit (ICU) deaths may follow neurological or systemic pathways, but the relationship between early prognostic measures and the mechanism of death is unclear. Methods: We retrospectively reviewed 2...

Clinical Outcomes in Initial Hirudotherapy versus Standard Treatment in Idiopathic Granulomatous Mastitis: A Comparative Cohort Study

Objective: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disease characterized by a high risk of recurrence and fistula formation. Spontaneous remission has been reported in up to 50% of cases, particularly in mild forms, within 6-24 months without interventio...

Depression, anxiety and stress symptoms in women with polycystic ovary syndrome with and without fertility treatment and in non-PCOS controls: a cross-sectional comparative study

Abstract Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder of reproductive-aged women that has been linked to psychological difficulties such as depressive and anxiety symptoms. We compared Depression Anxiety Stress Scale-21 (DASS-21) scores between women...

Association of blood parameters and ratios with aseptic loosening after total knee arthroplasty

This study aimed to evaluate the association of blood parameters and ratios with knee prosthesis loosening in patients after knee arthroplasty. A total of 221 patient files having knee prosthesis attempting to our clinic between 2018 and 2022 were retrospectively examined. Patien...

Resilience and Family Factors in Fibromyalgia: Associations with Disease Severity and Impact

Background: Fibromyalgia is a chronic pain syndrome influenced by biological and psychosocial factors, making resilience and family environment potential determinants of disease outcomes. This study aimed to evaluate psychological resilience and family-related factors in women wi...

Histopathological subtypes of gastric neuroendocrine cell hyperplasia: a cross-sectional association with hypergastrinemia and coexisting gastric lesions at index endoscopy

Gastric neuroendocrine cell hyperplasia (NECH) is a hypergastrinemia-driven spectrum of enterochromaffin-like cell proliferation that may precede or coexist with well-differentiated gastric neuroendocrine tumors (g-NETs). However, the clinical relevance of specific histologic pat...

A hidden coronary cause of cardiogenic shock after exercise in a child: a case report

Malignant left main coronary artery (LMCA) anomalies are rare but potentially fatal congenital defects that may cause myocardial ischemia or sudden cardiac death during exertion, even in otherwise healthy children. Early recognition and timely intervention are crucial to prevent...

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...

Online-Initiated Contact and Child Sexual Abuse Severity: A Forensic Cross-Sectional Study

Background/Objectives: Digital technologies have created new pathways through which perpetrators can initiate contact with children, yet evidence directly comparing child sexual abuse (CSA) cases according to the mode of first contact between the victim and the perpetrator remain...

Temporal distribution of recorded intensive care unit deaths across the 24-hour cycle: a 15-year retrospective hospital-based study

Whether recorded deaths in intensive care units (ICUs) follow a uniform temporal distribution throughout the 24-hour cycle remains uncertain. Previous studies have primarily compared broad day–night periods, potentially overlooking finer temporal patterns. We investigated the tem...

Magnetic Intramedullary Lengthening Nails for Complex Lower Extremity Reconstruction: Functional Outcomes, Bone Healing, and Complications

Background: Magnetically controlled intramedullary lengthening nails have become increasingly popular for lower extremity reconstruction because they reduce complications associated with external fixation and facilitate earlier rehabilitation. However, comprehensive data integrat...