Amsterdam Neuroscience

Langerhans cells as targets of rabies virus immune evasion

Rabies virus (RABV) is a neurotropic virus of the genus Lyssavirus that causes a nearly always fatal encephalitis in humans once it reaches the central nervous system. Dog bites are a major transmission route of RABV, and following superficial skin exposure, RABV first encounters...

Impact of neoprene wetsuits on lung volumes and work of breathing: implications for military diver safety and performance

Introduction: Neoprene wetsuits may impose mechanical constraints on the chest wall, potentially altering respiratory function. This study investigated the impact of neoprene wetsuits on lung volumes, airway mechanics, and work of breathing (WOB) in healthy male divers. Methods:...

The Role and Assessment of Lipid Profile in Patients With a Chronic Total Coronary Occlusion

ABSTRACT Adequate lipid management is a crucial component in the treatment of chronic coronary syndromes, a group of conditions that also encompasses patients with chronic total coronary occlusions (CTOs). Importantly, atherosclerotic progression may be especially rapid in patien...

Annual Research Review: Sex differences in conduct disorder – revisiting existing evidence and exploring future directions

Conduct disorder (CD) is a common psychiatric disorder in youth, characterized by severe and recurrent aggressive and antisocial behaviors and associated with substantial healthcare and societal costs. Rates of CD increase during adolescence in both sexes, with the male‐to‐female...

Associations between reduction of hypotension and treatment intensity in hypotension prediction index studies

BACKGROUND: The Hypotension Prediction Index (HPI) is developed for proactive prevention of hypotension and existing meta-analyses report reduced hypotension with HPI-guided management in comparison with a strategy based on MAP alerts of 65 mmHg. Still, validation studies suggest...

Early‐stage myocardial changes are not aggravated by Western diet or ageing in Mybpc3 c.2373insG heterozygous mice

Abstract Hypertrophic cardiomyopathy (HCM) caused by heterozygous pathogenic gene variants is characterized by highly variable disease phenotypes. Ageing and systemic metabolic disruption are thought to act as additional ‘second hits’ that modulate this genotype–phenotype relatio...

Prevalence, clinical characteristics and treatment response of tremor in chronic inflammatory demyelinating polyneuropathy

Background Tremor can be a disabling symptom of chronic inflammatory demyelinating polyneuropathy (CIDP). Studies on tremor in CIDP are limited and generally include small populations. We aim to determine the prevalence, clinical characteristics and treatment response of tremor i...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

Autistic neural ‘shiftability’: the distinct pharmacological landscape of the autistic brain

Functionally inter-connected large-scale brain networks regulated by multiple neurotransmitter systems underpin complex human behaviour. A wide range of alterations in this neurofunctional landscape have been associated with autism. However, this evidence is mostly derived from c...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Interventions to reduce diabetes-related distress among adults with type 1 and type 2 diabetes: protocol for a systematic review and meta-analysis

Diabetes distress (DD) refers to the emotional and psychological burden experienced by individuals living with diabetes. Randomized controlled trials (RCTs) have investigated the efficacy of interventions on DD among adults with type 1 diabetes or type 2 diabetes. We aimed to sys...

Long-Term Health-Related Quality of Life Outcomes in Patients With Cellulitis Requiring Hospitalisation

In 94 hospitalised patients with cellulitis, HRQoL was markedly impaired at admission and remained significantly below population norms at 90 days, particularly in patients with persistent pain and oedema. These findings highlight the need for post-discharge follow-up focused on...

The LoVe score: Development and validation of a bedside clinical index to identify patients at risk for prolonged invasive mechanical ventilation

Background: Early management decisions after intubation, such as humidification strategy or initiation of prevention bundles for ventilator-associated pneumonia, often depend on the expected duration of invasive mechanical ventilation (IMV). However, no simple, standardised metho...

Rethinking intensive salvage therapy in the venetoclax era

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Reducing sialylation in melanoma increases classical pathway-mediated complement activation

Summary Based on the success in pre-clinical models, methods that reduce sialylation in tumors have progressed to clinical trials, as this improves anti-tumor cellular responses. Immune responses against cancer can also be mediated by soluble, non-cellular mechanisms, such as the...

Divergent complication patterns of type 2 diabetes in African individuals who are lean versus overweight or obese: a multi-cohort analysis

Abstract Aims/hypothesis Nearly 40% of African adults with type 2 diabetes are lean (BMI <25 kg/m 2 ). Emerging evidence suggests that type 2 diabetes in African individuals who are lean may represent a distinct phenotype driven by impaired insulin secretion rather than insulin r...

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

P1.174. Fluorescence Guided Lymph Node Dissection Using Indocyanine Green During Minimally Invasive Esophageal Cancer Surgery [IGLO] - Pilot-Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Standardization of lymphadenectomy extent in esophageal cancer surgery is complex due to the heterogenous lymphatic drainage patterns. Fluorescence guided lymph node dissection using...

P1.175. Lymph Node Assessment of the Thoracic Duct and Surrounding Compartment in Esophageal Cancer Surgery – the TUPEC Pilot-Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Standardization of thoracic duct (TD) management during esophageal cancer surgery remains controversial. TD resection has been hypothesized to enhance oncologic radicality, since it may increase...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...