Institution
Allen Institute for Brain Science
Recent research
- Health & MedicineOpen access
Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS
Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...
- Climate & EnvironmentOpen access
Frogs, filters, and faraway lands: honoring the inimitable neuroethology of Peter Narins
This Special Issue of the Journal of Comparative Physiology A continues the journal’s tradition of recognizing pioneering neuroethologists by honoring Peter M. Narins. A former Associate Editor of the Journal and an influential colleague to researchers worldwide, Peter has profou...
- BiologyOpen access
Abstract Visuomotor association involves linking an arbitrary visual cue to a well-learned movement. Transient inactivation of Crus I/II impairs primates’ ability to learn new associations and delays motor responses without affecting the kinematics of the movement. The simple spi...
- Health & Medicine
Abstract Introduction There is a critical need to identify and routinely measure the outcomes that matter most to people living with glioma. Care needs in this population are complex and variable, yet current clinical practice lacks consistent, systematic approaches to assessing...
- BiologyOpen access
Transient gamma events delineate somatosensory modality in S1
Gamma band activity localized to the primary somatosensory cortex (S1) in humans and animals is implicated in the higher order neural processing of painful and tactile stimuli. However, it is unclear if gamma band activity differs between these distinct somatosensory modalities....
- BiologyOpen access
Abstract The perception of complex visual shapes is a hallmark of primates and a foundation for many of their decisions and actions. The neural mechanisms of this visual function are best studied in macaques, but progress in this animal model has been hampered by the inability to...
- BiologyOpen access
Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering
Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is critical for understand...
- Health & MedicineOpen access
Abstract Objective To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status. Methods In this post hoc analysis, data from three ran...
- AI & ComputingOpen access
The perils of omitting omissions when modeling evidence accumulation
Response deadlines are commonly imposed in decision-making research to incentivize speedy decisions and sustained attention. This procedure frequently leads to a proportion of trials in which no response is made, and these omissions are often simply removed from the data during a...
- Health & MedicineOpen access
Abstract Programmed cell death protein 1 (PD-1) is expressed by T cells during progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease caused by the human-only JC polyomavirus. Why PD-1 blockade finds variable success in PML patients is unclear. Brain C...
- Materials & EnergyOpen access
ABSTRACT Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion are key molecular markers for glioma classification. Amide proton transfer weighted (APTw) and nuclear Overhauser effect–weighted (NOEw) markers showed promise for glioma characterization, by probing protein‐r...
- Health & MedicineOpen access
Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...
- BiologyOpen access
Fear extinction and its persistence depend on epigenetic modifications, which can be potentiated by histone deacetylase inhibitors (HDACis). Butyrate (NaBu), a short-chain fatty acid and endogenous HDACi, promotes persistent fear extinction in rodent models by increasing histone...
- BiologyOpen access
18 F-SynVesT-1 is a PET tracer targeting synaptic vesicle protein 2A, a surrogate marker of synaptic density. Simplified quantification using pseudo-reference regions such as the centrum semiovale (CSO) or whole cerebellum (CER) has previously been validated in healthy volunteers...
- BiologyOpen access
Abstract A bidirectional relationship has been proposed between sleep and Alzheimer’s disease pathology, such that disruption to sleep can lead to increases in the expression of tau or its phosphorylation. Over the long term, this can potentially lead to greater expression of neu...
- BiologyOpen access
BACKGROUND: Differentiating myogenic from neurogenic neuromuscular diseases (NMDs) can be clinically challenging. While quantitative muscle MRI (qMRI) with proton density fat fraction (PDFF,%) quantifies fat replacement, it misses micro-spatial patterns linked to underlying patho...