Alfred Health

Effects of testosterone on exercise capacity in postmenopausal women with stage B heart failure

Objective Asymptomatic individuals with stage B heart failure (HF) often have reduced exercise capacity. As exogenous testosterone may have favorable skeletal muscle and vasculature effects, this study investigated whether transdermal testosterone improves exercise capacity in wo...

“I Didn't Realise It Still Impacted Me, but Obviously, It Still Does:” Personal Outcomes of Code Grey Events for Healthcare Professionals

ABSTRACT Aim To explore the personal effects of aggression and violence towards healthcare professionals, specifically before, during and after Code Grey events. Design Qualitative descriptive study design. Methods Semi‐structured interviews were conducted with 35 healthcare prof...

A Review on Current Challenges and Knowledge Gaps in Artificial Stone Silicosis

BACKGROUND: The global emergence of artificial stone (AS) silicosis represents a critical occupational health challenge. The aim of this systematic review is to provide an overview of the clinical, functional, radiological, and occupational characteristics of patients affected by...

Seizure control and foetal malformation in primiparous women with Epilepsy: statistical analysis of data from a prospective observational study

Purpose To evaluate seizure control and foetal malformation in the first pregnancy of women with epilepsy through the analysis of the Australian Pregnancy Register database focusing of women with epilepsy intending or beginning their first pregnancy. This was achieved through a s...

Early life trauma and endometriosis: A case-control study on type and timing of adverse experiences

PURPOSE: Endometriosis is a common chronic inflammatory gynaecological condition characterised by the abnormal presence of endometrial tissue outside the uterus. Different risk factors for endometriosis have been proposed, with some research finding a significant relationship bet...

Evaluation of external ventricular drain performance under hyperbaric conditions: a bench study

Introduction: External ventricular drains (EVDs) are widely used for intracranial pressure (ICP) monitoring and cerebrospinal fluid (CSF) diversion in neurocritical care. Hyperbaric oxygen treatment (HBOT) exposes medical devices to increased ambient pressure; however, limited da...

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants

Importance The optimal initial fraction of inspired oxygen (F io 2 ) for delivery room resuscitation of neonates born at 32 to 35 weeks’ gestation is unknown. Objective To compare outcomes for neonates born at 32 to 35 weeks’ gestation when initiating resuscitation with F io 2 0....

Point‐of‐care ultrasound in general medicine: establishing a new service

Point-of-care ultrasound (POCUS) is increasingly used in general medicine to support focussed bedside diagnosis and management. However, many implementation models depend on individual clinicians scanning their own patients. This limits equity of access, slows accumulation of pro...

Single-dose Preoperative Glucocorticoids in Major Gastrointestinal Surgery

OBJECTIVE: To evaluate the clinical efficacy and safety of single-dose preoperative systemic glucocorticoids in adults undergoing major gastrointestinal surgery. SUMMARY OF BACKGROUND DATA: Major gastrointestinal surgery induces a systemic inflammatory response that contributes t...

Artificial intelligence tools in sepsis prediction: a systematic review and meta-analysis

Abstract Background Machine learning (ML) models have been used to improve diagnosis of sepsis, but their effectiveness is uncertain. We aimed to systematically evaluate the diagnostic accuracy of ML models for sepsis prediction through a systematic review and network meta-analys...

HITH4HIPs: a feasibility trial of hospital in the home after hip fracture

In Australia, as in many other jurisdictions, people with low-trauma hip fractures often stay in hospital for extended periods, even when medically stable, increasing risk of hospital-related complications and increasing healthcare costs. In this context, we sought to determine t...

Pre-existing systemic and nasal antibodies against avian H5 influenza A viruses vary according to childhood imprinting

Avian influenza A viruses (IAVs) pose a constant pandemic threat, with the recent 2.3.4.4b clade of the H5 subtype causing high pathogenicity and spreading across animal species and geographic locations. Understanding human pre-existing immunity to avian H5 IAV can inform on popu...

The association between documented right ventricular dysfunction and in-hospital mortality in mechanically ventilated critically ill patients receiving a noradrenaline infusion: A retrospective observational cohort study

Objective To determine the documentation of right ventricular dysfunction (RVD) in mechanically ventilated patients receiving a noradrenaline infusion, and to assess the association with in-hospital mortality, length of stay (LOS) and treatment intensity. Design and setting This...

Presymptomatic plasma biomarkers in autosomal dominant Alzheimer’s disease: sequence and timing

Abstract Background Autosomal dominant Alzheimer’s disease (ADAD) serves as a model for presymptomatic biomarker discovery. Characterising the temporal profile of plasma biomarker levels in presymptomatic individuals may enhance understanding of disease pathogenesis, inform futur...

P1.153. Dietitian-Led Integration of CT Body Composition Analysis in Oesophagogastric Cancer Care

Abstract Topic Esophageal Cancer: Other Background Malnutrition and poor muscle health are prevalent in patients with oesophagogastric cancer and are associated with poor outcomes. However, body composition assessment is not routinely implemented in clinical practice. This projec...

Generalisation between motor and declarative memory sequences: A conceptual replication of Mosha & Robertson (2016).

= 125) completed a word list and motor sequence task in counterbalanced order with either a shared or distinct sequence structure. In contrast to Mosha and Robertson (2016), we found that a shared ordinal structure between the declarative and motor sequence tasks did not facilita...

Aorto‐Ostial Lesion Percutaneous Coronary Intervention: Clinical Characteristics, Predictors and Clinical Outcomes

ABSTRACT Background Aorto‐ostial coronary lesions represent a high‐risk subset of coronary disease because of fibrocalcific disease, elastic recoil, and difficulty achieving precise stent positioning. Percutaneous coronary intervention (PCI) of these lesions may therefore be asso...

Following the rules: which type 1 diabetes guidelines, protocols and recommendations are tertiary clinics in Australia following? A quantitative study

OBJECTIVES: This study characterises the use of type 1 diabetes (T1D) guidelines and protocols in Australian T1D clinics working with paediatric patients, and determines if management practices align with T1D-specific guidelines. METHODS: T1D clinic service leaders responded to a...

Impact of socioeconomic status on treatment and survival in multiple myeloma in Australia

<title>Abstract</title> Outcomes in multiple myeloma (MM) have improved significantly but remain heterogeneous. We assessed the impact of non-biological social determinants of health on treatment and survival outcomes in Australia using data from the Australian and New Zealand My...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...