Alexandria University

Bridging MOE with eco-friendly chromatographic analyses of metformin and ursodeoxycholic acid with their official impurities: Multi-metric sustainability assessment

In response to the increasing demand for sustainable and reliable analytical approaches, this study presents the development of two environmentally friendly, selective, and robust chromatographic methods for the concurrent determination of metformin and ursodeoxycholic acid in th...

Aucubin Ameliorates Alloxan-Induced Diabetic Liver Injury in Association with Modulation of the Nrf2/HO-1 Antioxidant Axis and NF-κB-Associated Inflammatory and Apoptotic Signaling

Diabetes mellitus is associated with progressive hepatic injury driven by oxidative stress, inflammation, and apoptosis. Aucubin, a natural iridoid glycoside, possesses potent antioxidant and anti-inflammatory activities; however, its hepatoprotective mechanisms in diabetic liver...

Multivariate analysis of 110 green super rice (GSR) lines for morpho-physiological diversity attributes

Genetic diversity present in rice genotypes plays a crucial role in improving breeding strategies and developing high-quality cultivars. This study evaluated genetic diversity, agronomic performance, and disease resistance across 110 unique rice cultivars over two growing seasons...

Lycopene mitigates T-2 toxin-induced systemic inflammation and oxidative stress in association with gut microbiota and SCFAs regulation in mice

T-2 toxin is a trichothecene mycotoxin produced by Fusarium species and can cause disease after contaminated food or feed ingestion. This study aimed to investigate the impact of lycopene (Ly) on systemic inflammation, oxidative stress, and dysbiosis in mice exposed to T-2 toxin....

A Spectral Tau Algorithm Using Shifted Convolved Fibonacci Polynomials for Singular Functional Models

In this paper, for some second-order singular functional differential equations (SOSFDEs), a tau-type spectral technique is built using non-origin-symmetric polynomials called shifted convolved Fibonacci polynomials as the approximation basis. Derivative formulae, integral identi...

Integrative Multi‐Omics Analysis of Stem Growth Habit Divergence in Wild Soybean ( Glycine soja )

Stem architecture is a major determinant of lodging resistance, biomass accumulation, and harvest efficiency in soybean. However, the molecular features associated with contrasting stem growth habits in wild soybean remain incompletely characterised. Here, we performed an integra...

The Impact of Sustainability Audit on Climate Change Performance: The Role of Governance Quality and Greenwashing

ABSTRACT This study investigates how sustainability audit quality influences corporate climate change performance and examines the moderating roles of governance quality and greenwashing. Using panel regressions on 6140 firm‐year observations from 39 countries between 2008 and 20...

Comparative effects of atorvastatin and rosuvastatin on inflammatory biomarkers: a systematic review and meta-analysis of randomized head-to-head trials

Abstract Background Inflammation contributes significantly to cardiovascular disease progression. While both atorvastatin and rosuvastatin have anti-inflammatory effects, evidence directly comparing their effects on inflammatory biomarkers is limited and inconsistent. This study...

Pathology-Guided Transcriptomic Profiling of Prostate Cancer Identifies Grade-Associated Proliferative and Immune Signatures in a MENA Cohort

Background: Prostate cancer (PC) is a heterogeneous disease in which the histopathological grade does not always reflect underlying biological behavior. While transcriptomic studies have provided insight into tumor biology, grade-associated molecular changes remain incompletely d...

Evaluation of the new Egyptian undergraduate medical program from students’ perspectives: a nationwide cross-sectional study

Abstract Background The global emphasis on medical education reform highlights the need for essential competencies to meet evolving healthcare demands. In Egypt, significant reforms in 2018 introduced a competency-based, integrated undergraduate medical curriculum—a five-year pro...

Rethinking Post-Disaster Shelters: An Integrated LCA of Environmental, Techno-Economic and Resilience Across Three Modern Methods of Construction

The increasing frequency and severity of natural and human-induced disasters are intensifying the need for post-disaster shelters that can be rapidly deployed while delivering low environmental impact, affordability and acceptable occupant comfort. Modern Methods of Construction...

Exploring the journey towards evidence-based clinical decision-making among emergency care personnel

Emergency care personnel play a critical role in providing timely and effective care, where the use of evidence-based practices is essential for informed clinical decision-making. This study explored the extent to which emergency care personnel incorporate evidence-based practice...

Assessment of water use efficiency in arid ecosystems of the coastal land of Egypt using MODIS dataset

Abstract In drylands, the limited availability of reliable measurements makes it more difficult to understand how climatic and biogeochemical factors shape ecosystem processes across spatial gradients compared to mesic or humid regions. Water use efficiency (WUE) is a key physiol...

Beyond the Burgers paradigm: the stabilizing role of higher-order nonlinearities in magnetized heavy ion-acoustic shocks

Abstract This paper investigates the role of higher-order nonlinearities in the propagation of heavy ion-acoustic shock waves (HIASWs) within a magnetized, collisionless plasma comprising inertial heavy ions and kappa-distributed electrons and positrons. Employing a reductive per...

Sustainability-Driven Seismic Resilience Assessment and Multiobjective Optimization of DSM-Retrofitted RC Bridges on Liquefiable Ground

Abstract Sustainability and seismic resilience are increasingly essential for infrastructure systems, prompted by the demand to endure more frequent extreme events while minimizing environmental impacts. This paper presents a sustainability-driven, multiobjective framework for as...

Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment

The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a major therapeutic target in type 2 diabetes and obesity. Missense variation in GIPR could confer phenotypic effects through alterations to constitutive activity or functional responses to GIP or pharmacological...

Sodium supplementation strategies in preterm infants: effects on growth, electrolyte balance, and exploratory evidence on neurodevelopment — a systematic review and meta-analysis

This study evaluated the effects of sodium supplementation on growth, electrolyte balance, and neurodevelopmental outcomes in preterm infants. A systematic review and meta-analysis of published studies were conducted using data from PubMed, Embase, Scopus, and Google Scholar, inc...

Impact of sex and HLA-B27 positivity on clinical characteristics and patient-reported outcomes in a cohort of Egyptian axial spondyloarthritis patients

Abstract Objective: To assess the clinical features, disease activity, functional status, and quality of life in Egyptian patients with axial spondyloarthritis (axSpA), and to explore the influence of gender and HLA-B27 status on disease expression. Methods: This cross-sectional...

Evaluation of thermocycling, color stability, surface roughness and hardness of nanocarbon HPP, BioHPP and PEEK used for fabrication of prosthetic restorations ( in vitro study)

Abstract Statement of problem The selection of appropriate dental materials plays a crucial role in the success of prosthetic restorations. With the limitations of metallic alloys, including their aesthetic shortcomings, weight, corrosion potential, and cost, there is growing int...

Clinical integration of trabecular bone score in precision osteoporosis care: a position statement by the Egyptian academy of bone and muscle health

Abstract Background Dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) has long been the gold standard for osteoporosis diagnosis, yet its inability to account for bone quality leads to a significant “sensitivity gap” in fracture risk prediction. This posit...